Helen Moore

Helen Moore, PhD

Associate Professor

Department: MD-PULMONARY SYSTEMS MEDICINE
Business Phone: (352) 273-9552

About Helen Moore

Dr. Helen Moore graduated from the North Carolina School of Science and Mathematics and the University of North Carolina at Chapel Hill. She received her PhD in mathematics in 1995 from Stony Brook University. Her original work in differential geometry focused on shapes that minimize volume under constraints. While in academia, she won two teaching awards and received a National Science Foundation grant for her research. She was on the faculty at Bowdoin College and Stanford University, and also worked at a research mathematics institute. At Stanford, Dr. Moore collaborated with medical school faculty, shifting her use of optimization techniques to apply them to therapies for cancer, HIV, and hepatitis C.

From 2006-2021, Dr. Moore worked in the biopharma industry, including Genentech, Certara, Bristol-Myers Squibb, AstraZeneca, and Applied BioMath. Dr. Moore was selected as a Fellow of the Society for Industrial and Applied Mathematics in 2018, with the following citation: “For impactful industrial application of mathematical modeling in oncology, immunology, and virology. For mentoring, teaching, and leadership.”

Dr. Moore returned to academia in 2021, joining the Laboratory for Systems Medicine in the College of Medicine at the University of Florida. She currently has three main areas of research: modeling disease-immune dynamics, assessing systems model predictions, and optimizing combination drug regimens.

Research Profile

Areas of Interest
  • Mechanism-based mathematical modeling

Publications

Academic Articles
2025
Quantitative methods to improve bivalirudin dosing in pediatric cardiac ICU patients.
Perfusion. [DOI] 10.1177/02676591251324648. [PMID] 40014868.
2025
Stronger together: a cross-SIG perspective on improving drug development.
Journal of pharmacokinetics and pharmacodynamics. 52(1) [DOI] 10.1007/s10928-024-09960-5. [PMID] 39825146.
2024
A perfectly imperfect engine: Utilizing the digital twin paradigm in pulmonary hypertension.
Pulmonary circulation. 14(2) [DOI] 10.1002/pul2.12392. [PMID] 38933181.
2023
Determining optimal combination regimens for patients with multiple myeloma.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 187 [DOI] 10.1016/j.ejps.2023.106492. [PMID] 37302768.
2023
Medical mathematics outside of math departments
Society for Industrial and Applied Mathematics News. 56(4):7-8
2023
Modeling jobs in the biopharma industry
Notices of the American Mathematical Society. 70(5):765-768 [DOI] 10.1090/noti2679.
2023
Quantitative methods for optimizing patient outcomes in liver transplantation
Liver Transplantation. [DOI] 10.1097/lvt.0000000000000325.
2022
Evaluation framework for systems models.
CPT: pharmacometrics & systems pharmacology. 11(3):264-289 [DOI] 10.1002/psp4.12755. [PMID] 34921743.
2021
Early predictions of response and survival from a tumor dynamics model in patients with recurrent, metastatic head and neck squamous cell carcinoma treated with immunotherapy
CPT: Pharmacometrics & Systems Pharmacology. 10(3):230-240 [DOI] 10.1002/psp4.12594. [PMID] 33465293.
2019
Perspectives on the Role of Mathematics in Drug Discovery and Development
Bulletin of Mathematical Biology. 81(9):3425-3435 [DOI] 10.1007/s11538-018-00556-y.
2019
The Mathematical and Computational Sciences Special Interest Group of the International Society of Pharmacometrics.
CPT: pharmacometrics & systems pharmacology. 8(7):433-435 [DOI] 10.1002/psp4.12410. [PMID] 30983157.
2019
What Can Mathematics Do for Drug Development?
Bulletin of Mathematical Biology. 81(9):3421-3424 [DOI] 10.1007/s11538-019-00632-x. [PMID] 31332601.
2018
A Mathematical Model for Tumor–Immune Dynamics in Multiple Myeloma
Association for Women in Mathematics Series. 89-122 [DOI] 10.1007/978-3-319-98083-6_5.
2018
How to mathematically optimize drug regimens using optimal control
Journal of Pharmacokinetics and Pharmacodynamics. 45(1):127-137 [DOI] 10.1007/s10928-018-9568-y. [PMID] 29411198.
2018
Methods for determining key components in a mathematical model for tumor–immune dynamics in multiple myeloma
Journal of Theoretical Biology. 458:31-46 [DOI] 10.1016/j.jtbi.2018.08.037.
2018
Optimal control applied to a generalized Michaelis-Menten model of CML therapy
Discrete & Continuous Dynamical Systems – B. 23(1):331-346 [DOI] 10.3934/dcdsb.2018022.
2018
Optimization of combination therapy for chronic myeloid leukemia with dosing constraints
Journal of Mathematical Biology. 77(5):1533-1561 [DOI] 10.1007/s00285-018-1262-6.
2016
Dynamical Systems Properties of a Mathematical Model for the Treatment of CML
Applied Sciences. 6(10) [DOI] 10.3390/app6100291.
2013
Mathematical Modeling of Tumor Cell Proliferation Kinetics and Label Retention in a Mouse Model of Lung Cancer
Cancer Research. 73(12):3525-3533 [DOI] 10.1158/0008-5472.can-12-4244.
2013
Model-Supported Development of CS-8635: A Fixed-Dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide
Clinical Pharmacology in Drug Development. 2(2):103-112 [DOI] 10.1002/cpdd.17.
2011
Mathematical Rx
Expeditions in Mathematics. Eds. Shubin, Hayes, Alexanderson. 261-274
2007
Optimal control of treatment in a mathematical model of chronic myelogenous leukemia
Mathematical Biosciences. 210(1):143-156 [DOI] 10.1016/j.mbs.2007.05.003.
2007
Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo
Proceedings of the National Academy of Sciences. 104(45):17747-17752 [DOI] 10.1073/pnas.0706485104. [PMID] 17965232.
2006
Differential equation models of diseases and drug modeling
Women in Mathematics: The Legacy of Ladyzhenskaya and Oleinik Conference Proceedings. Ed. Kuperberg. 197-201
2006
Optimal therapy regimens for treatment-resistant mutations of HIV
Contemporary Mathematics. 410:139-152
2005
A mathematical model for treatment-resistant mutations of HIV
Mathematical Biosciences and Engineering. 2(2):363-380 [DOI] 10.3934/mbe.2005.2.363.
2004
A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction
Journal of Theoretical Biology. 227(4):513-523 [DOI] 10.1016/j.jtbi.2003.11.024.
1999
STABLE MINIMAL HYPERSURFACES AND TANGENT CONE SINGULARITIES
International Journal of Mathematics. 10(03):407-413 [DOI] 10.1142/s0129167x9900015x.
1996
Minimal submanifolds with finite total scalar curvature
Indiana University Mathematics Journal. 45(4):1021-1043

Education

PhD
1995 · Stony Brook University

Contact Details

Phones:
Business:
(352) 273-9552
Emails:
Addresses:
Business Mailing:
PO Box 100225
GAINESVILLE FL 32610
Business Street:
PO Box 100225
GAINESVILLE FL 32610