The Moehle Lab is interested in understanding the physiological, circuitry, and behavioral changes that cause the motor and non-motor symptoms of movement disorders and then translate these findings into novel therapeutics for these disorders. We use diverse animal models of disease to understand how these basal-ganglia centric disorders develop. These include commonly available models such as the pre-formed fibril model of alpha-synucleinopathies (i.e. Parkinson’s Disease and Dementia with Lewy Bodies) as well as models developed by our lab (GNAL linked dystonia). To answer these questions, we utilize a number of cutting edge electrophysiology, optical neuroscience, behavioral and fiber photometry techniques. Together, our models and techniques will allow us to make novel, impactful discoveries about the etiology of movement disorders for the benefit of patients afflicted with these disorders.