The May Khanna Lab

May Lab Group Pic

Research Overview

The May Khanna Laboratory focuses on developing small molecule therapeutics for neurodegenerative diseases. Our approach combines biochemical and biophysical techniques to target key protein-protein and protein-RNA interactions that play a role in these diseases. The ultimate goal of our research to contribute to the discovery of novel treatments for conditions with limited or no therapeutic options.

What we are doing in our lab

Research Focus Area

• RNA-Protein Interactions in ALS
• Structural Analysis and In Silico Drug Discovery for TDP-43
• RNA-Targeting Therapeutics for Cystic Fibrosis
• Pharmacological Chaperones for Batten disease
• Enzyme Inhibition for Diabetes

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what you would learn in our lab

Research Tools & Skills

The May Khanna Lab utilizes a variety of biophysical tools and techniques to study molecular interactions and develop new therapies. These tools and skills include: * Surface Plasmon Resonance (SPR) * Nuclear Magnetic Resonance (NMR) * X-ray Crystallography * Biochemical techniques * Targeting protein-protein interactions * Targeting protein-RNA interactions * Developing small molecule therapeutics * Pharmacological chaperone development * Enzyme inhibition and inhibitor development * Mass Photometry * Mass Spectrometry *Cryo-electron microscopy (cryo-EM)
Additionally, our lab utilizes animal models of neurodegenerative diseases, including fly models, to help advance the drug discovery efforts.

TDP43-HSP-sites

CURRENT & UP TO DATE PUBLICATIONS

Recent Publications

Check out the recent publications from the Primary Investigator (PI), Dr. May Khanna

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