Research Overview
The emphasis of the Russ lab is on developing innovative regenerative medicine approaches with a focus on understanding the underlying molecular and cellular mechanisms resulting in autoimmune type 1 diabetes (T1D) in humans. His lab employs state of the art human pluripotent stem cell technology and primary human cell/tissue culture with genome engineering approaches to model and potentially treat patients. The Russ lab has successfully worked on different aspects of translational research, which led to several original and important contributions to the fields of pancreatic beta-, thymus- and pluripotent stem cell- biology. Dr.Russ’s long term goal is to understand why T1D develops and develop novel intervention and treatment modalities and train and enable the next generation of scientists focused on regenerative medicine strategies.
WHAT WE ARE DOING IN OUR LAB
Research Focus Areas
• Autoimmunity
• Type 1 Diabetes
• Pancreatic beta cell generation, function and maturation
• Thymus biology
• Cell Replacement therapy
• Humanized mouse models
WHAT YOU WOULD LEARN IN OUR LAB
Research Tools & Skills
• Pluripotent stem cell culture
• Genome engineering using TALEN and CRISPR/Cas9 technology
• Human primary tissue and cell culture
• Reprogramming of somatic cells to iPSC
• Ribosomal profiling of the translatome in health and disease
• TCR-Peptide-HLA matched human immune beta cell co-culture in vitro and in vivo
• Novel humanized mouse models and transplantation studies
current & up to date publications
Recent Publications
Check out the recent publications from the Primary Investigator (PI), Dr. Holger Russ
