The Law Lab researches mechanisms by which CDCP1 Promotes Breast Cancer Metastasis: The CDCP1 protein functions as a scaffold to bring together and facilitate synergy between the oncoproteins Epidermal Growth Factor Receptor (EGFR) and the Src tyrosine kinase. This results in disassembly of cell-cell and cell-substratum adhesion complexes and may facilitate cancer metastasis by permitting cancer cell invasion and de-adhesion.
Current work is directed toward identifying pharmacological strategies to block the pro-metastatic functions of CDCP1. (Law, M., et al. Oncogene (2013) 32:1316; Law, M., et al. Breast Cancer Research (2016) 18:80).
Wang, M., et al. Cell Death Discovery (2019) 5:153
Law, M., et al. Breast Cancer Research (2016) 18:80
Wang, M., et al., Oncogene (2019) 38:4264
Law, M., et al. bioRxiv preprint doi: https://doi.org/10.1101/2021.01.13.426390
Law, M., et al. Oncogene (2013) 32:1316