The Casadesus Lab focuses on the study of fundamental physiological events that become deregulated by aging or poor lifestyle (environment) and have been identified as major effectors of neurodegenerative disorders. A major emphasis of the laboratory is to develop therapeutic strategies aimed at neuroprotection to prevent the development of AD. A current area of focus in is the study of fundamental endocrine/neuroendocrine mechanisms on CNS signaling and function. Particularly how dysregulation in such systems during in menopause or by age/life-style metabolic dysregulation impact on CNS function and AD risk.
Reproductive and metabolic hormones have receptor in CNS cell types that impact central excitatory, inflammatory, and plasticity mechanisms, yet their mechanisms and circuits remain ill defined. Therefore, current projects are directed toward identifying and understanding how specific reproductive and metabolic hormone/receptor complexes involved in these lifespan/lifestyle events affect CNS cellular/molecular functions to impact cognitive processes affected in AD pathogenesis.
More recently, the lab has expanded to incorporating transcriptomics and machine learning approaches to address the interplay between hormones dysregulation and sex differences and CNS dysfunction caused by environmental factors such as poor lifestyle or infection. The goal of this work is to advance precision medicine.
• Cell Culture
• Neuron Tracing
• AAV and Lentiviral delivery
• Immunohistochemistry and microscopy
• Behavioral pharmacology
• Protein analysis
Check out the recent publications from the Primary Investigator (PI), Dr. Gemma Casadesus