Brian K Law

Brian K Law, Ph.D.

Associate Professor & Vice Chair for Faculty Affairs

Department: MD-PHARMACOLOGY – THERAPEUTICS
Business Phone: (352) 273-9423
Business Email: bklaw@ufl.edu

On This Page

Teaching Profile

Courses Taught

Teaching Philosophy

TEACHING PHILOSOPHY STATEMENT Brian K. Law, Ph.D. A mind is a fire to be kindled, not a vessel to be filled. -Plutarch The purpose of a science course is to teach fundamental scientific principles and to bring the student to the realization that the application of basic scientific principles, when used according to the scientific method, allows the scientist to investigate any research problem in a logical and productive manner. The responsibilities of the teacher are several-fold. The teacher should present the empirical data that led to the formulation of individual principles so that the student realizes that scientific laws are not abstract principles, but rather have their basis in the very properties of nature itself. Once the student has grasped the fundamental principles, the teacher must demonstrate how these ideas can be used to pose and answer new and significant questions using the scientific method. As a teacher I use all the tools at my disposal to insure that each student has every opportunity to develop a strong foundation in scientific knowledge and its applications to allow the student to achieve his or her career goals. Lectures will be designed using a large number of examples and demonstrations such that the students themselves will come to the same conclusions reached by the great scientists of the past. Laboratory classes will be used to reinforce the lectures, as well as to give the students exposure to the science and the art of experimental design. I will hold flexible office hours so that students will be able to ask any questions or address any concerns. Office hours and “help sessions” will also allow me to determine which material proves particularly difficult to the students and should be covered more thoroughly in the lecture and laboratory classes. Students in graduate, undergraduate, and professional courses will be thoroughly exposed to the current literature in order to develop critical thinking skills. Critical thinking skills will be developed by critiquing journal articles in terms of (1) the significance or relevance of the scientific question addressed in the article, (2) the appropriateness of the experimental methods and controls used by the authors, (3) whether or not the experimental results obtained support the conclusions reached by the authors, and (4) whether alternate conclusions could be reached from the same experimental results. Since communication skills are critical to the success of future scientists, learners will be asked to present journal articles or solve problems in a team-based format in front of their peers and be critiqued by their peers. These experiences will demonstrate to the student in a dramatic way what makes up an effective presentation and how they can improve their communication and critical thinking skills. As a teacher at UF I have had the opportunity to instruct and guide a wide array of learners including medical students, dental students, graduate (Ph.D. and M.S.) students, and undergraduate research volunteers. If am familiar with multiple teaching modalities including didactic lecturing, flipped-classroom, and team-based learning approaches. I feel that these experiences have given me a wide array of educational skills that can be brought to bear in the classroom.

Research Profile

Some of the Law Lab’s primary research interests revolves around cyclin-dependent kinases (Cdks) in mammary tumorigenesis and chromosomal instability, and Cdk regulation by the mTOR and TGFβ pathways. This research involves the use of novel models to understand how the activation of Cdks in the mammary gland causes tumor formation by dysregulation of cell proliferation and through genetic alterations that result from chromosomal instability. These models also provide systems for testing new therapeutic strategies, including non-ATP competitive Cdk inhibitors discovered in their laboratory and for targeting the upstream signaling pathways, such as the mTOR and TGFβ axes, that stimulate Cdk kinase activity.

Other Areas of Interest

Mechanisms by which CDCP1 Promotes Breast Cancer Metastasis: The CDCP1 protein functions as a scaffold to bring together and facilitate synergy between the oncoproteins Epidermal Growth Factor Receptor (EGFR) and the Src tyrosine kinase. This results in disassembly of cell-cell and cell-substratum adhesion complexes and may facilitate cancer metastasis by permitting cancer cell invasion and de-adhesion. Current work is directed toward identifying pharmacological strategies to block the pro-metastatic functions of CDCP1. (Law, M., et al. Oncogene (2013) 32:1316; Law, M., et al. Breast Cancer Research (2016) 18:80)

Activation of Death Receptors 4 and 5 by Altered Disulfide Bonding as a New Approach to Cancer Therapy: Our collaborative team identified a novel class of anticancer agents termed Disulfide bond Disrupting Agents (DDAs). DDAs selectively kill cancer cells that overproduce the oncoproteins Epidermal Growth Factor Receptor (EGFR/HER1), the EGFR family member, HER2, or the transcription factor MYC. DDA-induced cell death is mediated by the Death Receptors DR4 and DR5, which activate the Caspase 8-Caspase 3 pro-apoptotic cascade. Current work focuses on elucidating the molecular mechanisms by which DDAs activate DR4/5. (Wang, M., et al. Cell Death Discovery (2019) 5:153; Wang, M., et al., Oncogene (2019) 38:4264)   Identification of the First Active Site Inhibitors of the Disulfide Isomerases ERp44 and AGR2 as Novel Anticancer Agents: Affinity-tagged DDA molecules were used to identify the Protein Disulfide Isomerases ERp44, AGR2/3, and PDIA1 as the direct DDA target proteins in cancer cells that mediate DDA actions. Ongoing efforts are focused on understanding the structural features of the DDAs and their target proteins that control DDA target selectivity, and on determining the role of the DDA target enzymes in regulating the disulfide bonding patterns of their client proteins, Death Receptors 4 and 5, and the HER-family receptor tyrosine kinases EGFR and HER2. (Law, M., et al. bioRxiv preprint doi: https://doi.org/10.1101/2021.01.13.426390)

Areas of Interest

  • Cancer
  • Cell Cycle Regulation
  • Drug discovery

Publications

Academic Articles

Grants

Contact Details

Phones:
Business:
(352) 273-9423
Emails:
Business:
bklaw@ufl.edu
Addresses:
Business Mailing:
PO Box 100267
GAINESVILLE FL 32610
Business Street:
1200 NEWELL DRIVE
GAINESVILLE FL 32610