Kathleen T Shiverick, Ph.D.
Professor Emeritus
Department:
MD-PHARMACOLOGY / THERAPEUTICS
Business Phone:
(352) 262-7792
Business Email:
kshiveri@ufl.edu
Teaching Profile
Courses Taught
2006-2010
PHA4904 Pharmacology Research
2010
BMS6404 Pharmacology
2008,2010
GMS7593 Topics in Pharmacology and Toxicology
2009
IDS4906 Interdisciplinary Thesis Research
Publications
2016
Gene Expression Patterns Are Altered in Athymic Mice and Metabolic Syndrome Factors Are Reduced in C57BL/6J Mice Fed High-Fat Diets Supplemented with Soy Isoflavones.
Journal of agricultural and food chemistry.
64(40):7492-7501
[PMID] 27653593.
2011
Role of hypoxia and EGF on expression, activity, localization and phosphorylation of carbonic anhydrase IX in MDA-MB-231 breast cancer cells.
Biochimica et biophysica acta.
1813(1):159-67
[DOI] 10.1016/j.bbamcr.2010.09.018.
[PMID] 20920536.
2010
Detecting extracellular carbonic anhydrase activity using membrane inlet mass spectrometry.
Analytical biochemistry.
403(1-2):74-8
[DOI] 10.1016/j.ab.2010.04.019.
[PMID] 20417171.
2010
Human trophoblast responses to Porphyromonas gingivalis infection.
Molecular oral microbiology.
25(4):252-9
[DOI] 10.1111/j.2041-1014.2010.00573.x.
[PMID] 20618699.
2009
Antibody-specific detection of CAIX in breast and prostate cancers.
Biochemical and biophysical research communications.
386(3):488-92
[DOI] 10.1016/j.bbrc.2009.06.064.
[PMID] 19538935.
2009
Expression and activity of carbonic anhydrase IX is associated with metabolic dysfunction in MDA-MB-231 breast cancer cells.
Cancer investigation.
27(6):613-23
[DOI] 10.1080/07357900802653464.
[PMID] 19367501.
2009
IFPA meeting 2008 workshops report.
Placenta.
30 Suppl A(Suppl A):S4-14
[DOI] 10.1016/j.placenta.2008.11.014.
[PMID] 19084270.
2009
Localization of P. gingivalis in preterm delivery placenta.
Journal of dental research.
88(6):575-8
[DOI] 10.1177/0022034509338032.
[PMID] 19587165.
2009
Porphyromonas gingivalis invades human trophoblasts and inhibits proliferation by inducing G1 arrest and apoptosis.
Cellular microbiology.
11(10):1517-32
[DOI] 10.1111/j.1462-5822.2009.01344.x.
[PMID] 19523155.
2008
Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation.
The Prostate.
68(11):1223-31
[DOI] 10.1002/pros.20788.
[PMID] 18465755.
2008
Docetaxel and bortezomib downregulate Bcl-2 and sensitize PC-3-Bcl-2 expressing prostate cancer cells to irradiation.
World journal of urology.
26(5):509-16
[DOI] 10.1007/s00345-008-0289-5.
[PMID] 18594829.
2008
Interaction of P. Gincivalis With Human Extravillous Trophoblast Cells
Placenta.
29
2008
Isoflavones and gamma irradiation inhibit cell growth in human salivary gland cells.
Cancer letters.
270(1):87-94
[DOI] 10.1016/j.canlet.2008.04.051.
[PMID] 18585854.
2008
Phase II trial of isoflavone in prostate-specific antigen recurrent prostate cancer after previous local therapy.
BMC cancer.
8
[DOI] 10.1186/1471-2407-8-132.
[PMID] 18471323.
2007
Downregulation of BCL-2 induces downregulation of carbonic anhydrase IX, vascular endothelial growth factor, and pAkt and induces radiation sensitization.
Urology.
70(4):832-7
[PMID] 17991582.
2007
Increased expression of cyclooxygenase-2 correlates with resistance to radiation in human prostate adenocarcinoma cells.
The Journal of urology.
177(5):1913-7
[PMID] 17437847.
2007
Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenografts.
Molecular cancer therapeutics.
6(1):101-11
[PMID] 17237270.
2007
Placental enzymes and transporters: new functions and genetic polymorphisms–a workshop report.
Placenta.
28 Suppl A:S125-8
[PMID] 17382383.
2007
Soy isoflavones exert differential effects on androgen responsive genes in LNCaP human prostate cancer cells.
The Journal of nutrition.
137(4):964-72
[PMID] 17374662.
2006
Combination of PTEN gene therapy and radiation inhibits the growth of human prostate cancer xenografts.
Human gene therapy.
17(10):975-84
[PMID] 16984224.
2006
Soy isoflavones alter expression of genes associated with cancer progression, including interleukin-8, in androgen-independent PC-3 human prostate cancer cells.
The Journal of nutrition.
136(1):75-82
[PMID] 16365062.
2005
Benzo[a]pyrene, but not 2,3,7,8-TCDD, induces G2/M cell cycle arrest, p21CIP1 and p53 phosphorylation in human choriocarcinoma JEG-3 cells: a distinct signaling pathway.
Placenta.
26 Suppl A:S87-95
[PMID] 15837074.
2003
Drugs and the placenta–a workshop report.
Placenta.
24 Suppl A:S55-9
[PMID] 12842414.
2002
Mechanisms of the growth inhibitory effects of the isoflavonoid biochanin A on LNCaP cells and xenografts.
The Prostate.
52(3):201-12
[PMID] 12111696.
2001
Cell culture models of human trophoblast II: trophoblast cell lines–a workshop report.
Placenta.
22 Suppl A:S104-6
[PMID] 11312640.
1999
17Beta-estradiol modulates gastroduodenal preneoplastic alterations in rats exposed to the carcinogen N-methyl-N’-nitro-nitrosoguanidine.
Endocrinology.
140(10):4886-94
[PMID] 10499548.
1999
Cigarette smoking and pregnancy I: ovarian, uterine and placental effects.
Placenta.
20(4):265-72
[PMID] 10329346.
1999
Cigarette smoking and pregnancy II: vascular effects.
Placenta.
20(4):273-9
[PMID] 10329347.
1999
Endothelial cell chemotaxic activity expressed in rat placenta is not associated with prolactin-like proteins B and C.
Life sciences.
65(8):795-804
[PMID] 10466745.
1997
2,3,7,8-Tetrachlorodibenzo-p-dioxin increases mRNA levels for interleukin-1beta, urokinase plasminogen activator, and tumor necrosis factor-alpha in human uterine endometrial adenocarcinoma RL95-2 cells.
Biochemical and biophysical research communications.
238(2):338-42
[PMID] 9299508.
1997
Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell proliferation and c-myc and growth factor expression in human placental choriocarcinoma JEG-3 cells.
Biochemical and biophysical research communications.
231(1):117-20
[PMID] 9070231.
1997
Evidence that a mitogen-inducible prolactin-immunoreactive protein in rat spleen lymphocytes is aldolase A.
Life sciences.
60(24):2173-82
[PMID] 9188760.
1996
cDNA and protein sequence of a major form of P450, CYP2L, in the hepatopancreas of the spiny lobster, Panulirus argus.
Archives of biochemistry and biophysics.
329(1):31-8
[PMID] 8619632.
1996
Characterization of the aryl hydrocarbon receptor complex in human B lymphocytes: evidence for a distinct nuclear DNA-binding form.
Archives of biochemistry and biophysics.
336(2):297-308
[PMID] 8954578.
1996
Evaluation of immune parameters and lymphocyte production of prolactin-immunoreactive proteins after chronic administration of cocaine to pregnant rats.
The Journal of pharmacology and experimental therapeutics.
277(2):1090-6
[PMID] 8627520.
1996
Sequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals.
Endocrine reviews.
17(4):385-410
[PMID] 8854051.
1995
Cloning and expression of a rat placental cDNA encoding a novel cathepsin L-related protein.
Molecular reproduction and development.
40(2):146-56
[PMID] 7766407.
1995
Cloning of a novel rat placental prolactin-like protein C-related cDNA.
Molecular reproduction and development.
41(2):167-76
[PMID] 7654370.
1995
Effect of chronic cocaine administration on amino acid uptake in rat placental membrane vesicles.
Life sciences.
56(21):1779-87
[PMID] 7739352.
1995
Modulation by benzo[a]pyrene of epidermal growth factor receptors, cell proliferation, and secretion of human chorionic gonadotropin in human placental cell lines.
Biochemical pharmacology.
50(8):1171-80
[PMID] 7488231.
1995
Stimulatory effects of cocaine and its metabolites on IM-9 human B-lymphoblastoid cells.
International journal of immunopharmacology.
17(1):57-63
[PMID] 7782154.
1995
The Ah receptor recognizes DNA binding sites for the B cell transcription factor, BSAP: a possible mechanism for dioxin-mediated alteration of CD19 gene expression in human B lymphocytes.
Biochemical and biophysical research communications.
212(1):27-34
[PMID] 7541987.
1994
Expression and characterization of recombinant rat placental prolactin-like protein C.
Molecular and cellular endocrinology.
106(1-2):121-30
[PMID] 7895899.
1994
Fetoplacental growth and placental protein synthesis in rats after chronic maternal cocaine administration.
The Journal of pharmacology and experimental therapeutics.
270(1):392-8
[PMID] 8035337.
1992
Angiotensin-II induction of plasminogen activator inhibitor-1 gene expression in astroglial cells of normotensive and spontaneously hypertensive rat brain.
Molecular endocrinology (Baltimore, Md.).
6(12):2009-17
[PMID] 1491687.
1992
DNA adducts in humans as dosimeters of exposure to environmental, occupational, or dietary genotoxins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
6(11):2942-51
[PMID] 1644258.
1991
Angiotensin II induces secretion of plasminogen activator inhibitor 1 and a tissue metalloprotease inhibitor-related protein from rat brain astrocytes.
Proceedings of the National Academy of Sciences of the United States of America.
88(5):1928-32
[PMID] 2000398.
1991
Developmental expression of rat insulin-like growth factor binding protein-2 by astrocytic glial cells in culture.
Endocrinology.
129(2):1066-74
[PMID] 1713158.
1990
Benzo(a)pyrene inhibits epidermal growth factor binding and receptor autophosphorylation in human placental cell cultures.
Molecular pharmacology.
37(2):137-43
[PMID] 2154666.
1990
De novo synthesis and secretion of prolactin-like protein-B by rat placental explants.
Endocrinology.
126(5):2561-6
[PMID] 2328698.
1990
Identification of a novel family of growth hormone-related proteins secreted by rat placenta.
Endocrinology.
126(6):3271-3
[PMID] 2351117.
1990
Pregnancy-specific beta 1-glycoprotein messenger ribonucleic acid and immunoreactive protein in the rat testis.
Endocrinology.
126(1):292-8
[PMID] 2403519.
1989
Characterization of epidermal growth factor receptors in astrocytic glial and neuronal cells in primary culture.
Endocrinology.
124(1):240-7
[PMID] 2783308.
1989
Identification of proteins immunochemically related to human pregnancy-specific beta 1-glycoprotein in the rat placenta.
Endocrinology.
125(1):287-94
[PMID] 2786803.
1988
Effects of beta-naphthoflavone on insulin receptor binding and protein kinase activity in rat liver and placenta.
Molecular pharmacology.
33(3):250-6
[PMID] 2832720.
1988
Smoking-related alterations in epidermal growth factor and insulin receptors in human placenta.
Molecular pharmacology.
34(3):265-71
[PMID] 2843746.
1987
Extraction of omega- and omega-1-hydroxylauric acids with ethyl acetate results in formation of acetoxy products.
Drug metabolism and disposition: the biological fate of chemicals.
15(2):233-6
[PMID] 2882984.
1987
Formation of benzo[a]pyrene-DNA adducts by microsomal enzymes: comparison of maternal and fetal liver, fetal hematopoietic cells and placenta.
Chemico-biological interactions.
61(3):203-14
[PMID] 3568191.
1987
Ontogeny of insulin receptors in the rat hemochorial placenta.
Developmental biology.
123(2):487-93
[PMID] 3308578.
1986
Differential induction of ethoxyresorufin-O-deethylase in tissues of the rat placenta.
The Journal of pharmacology and experimental therapeutics.
238(3):1108-13
[PMID] 3746661.
1986
Effect of chronic treatment with estrogen and thyroxine, alone and combined, on the rate of deiodination of L-thyroxine to 3,5,3′-triiodothyronine in vitro.
Pharmacology.
33(1):52-7
[PMID] 3737676.
1986
Induction of cytochrome P-450c in hematopoietic cells of fetal liver.
Biochemical and biophysical research communications.
141(1):299-305
[PMID] 3541928.
1986
Positional metabolism of benzo(a)pyrene in rat placenta and maternal liver. Comparison of induction effects.
Drug metabolism and disposition: the biological fate of chemicals.
14(4):471-6
[PMID] 2873995.
1984
Cytochrome P-450-dependent oxidation of progesterone, testosterone, and ecdysone in the spiny lobster, Panulirus argus.
Archives of biochemistry and biophysics.
233(1):1-9
[PMID] 6431908.
1984
Effects of beta-naphthoflavone and 3-methylcholanthrene administered to pregnant rats on steroid metabolism in the isolated basal zone of the placenta.
The Journal of pharmacology and experimental therapeutics.
230(3):761-7
[PMID] 6470979.
1983
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) effects on hepatic microsomal steroid metabolism and serum estradiol of pregnant rats.
Biochemical pharmacology.
32(6):991-5
[PMID] 6301511.
1983
Effects of beta-naphthoflavone administration during midgestation on ovarian steroid metabolism and fetal development.
Progress in clinical and biological research.
135:383-7
[PMID] 6665013.
1983
Effects of beta-naphthoflavone administration to pregnant rats on steroid hormone biosynthesis and metabolism in ovarian microsomes.
The Journal of pharmacology and experimental therapeutics.
227(1):248-53
[PMID] 6620170.
1983
Effects of chronic administration of mestranol on alpha and beta adrenergic responsiveness in female rats.
The Journal of pharmacology and experimental therapeutics.
226(2):362-7
[PMID] 6308207.
1983
Mestranol-induced hypertension: characterization of cytochrome P-450 dependent catechol estrogen formation in brain microsomes.
Biochemical pharmacology.
32(1):101-6
[PMID] 6299293.
1983
Regulation of cytochrome P-450-dependent catechol estrogen formation in rat liver microsomes. Evidence for involvement of estrogen receptors.
Biochemical pharmacology.
32(16):2399-403
[PMID] 6311216.
1983
Stability of drug-metabolizing activities in lyophilized liver and lung microsomal preparations.
Drug metabolism and disposition: the biological fate of chemicals.
11(6):620-1
[PMID] 6140152.
1982
Differences in the regiospecific metabolism of testosterone as catalyzed by variant forms of rabbit microsomal cytochrome P-450 3b.
Biochemical and biophysical research communications.
109(3):786-91
[PMID] 7159441.
1982
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on serum concentrations and the uterotrophic action of exogenous estrone in rats.
Toxicology and applied pharmacology.
65(1):170-6
[PMID] 7147249.
1982
Effects of chronic treatment with thyroxine and estradiol on estrogen concentration in serum and on hepatic microsomal catechol estrogen formation in female rats.
The Journal of pharmacology and experimental therapeutics.
221(3):564-9
[PMID] 7086671.
1981
In vivo and in vitro effects of beta-naphthoflavone on cytochrome P-450-dependent testosterone hydroxylase activities in liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals.
9(6):545-50
[PMID] 6120814.
1980
In vitro hepatic deiodination of L-thyroxine to 3,5,3′-triiodothyronine in cold-acclimated rats.
Journal of applied physiology: respiratory, environmental and exercise physiology.
49(3):386-9
[PMID] 7204159.
1979
Multiplicity of testosterone hydroxylases in a reconstituted hepatic cytochrome P-450 system from uninduced male rats.
Drug metabolism and disposition: the biological fate of chemicals.
7(5):290-5
[PMID] 40768.
1978
Metabolism of [3H]epinephrine in rabbit fetal tissues.
Biochemical pharmacology.
27(4):451-5
[PMID] 629805.
1978
Physiologic disposition of [3H]epinephrine in the rabbit fetus. Effect of promethazine.
Biochemical pharmacology.
27(4):445-50
[PMID] 629804.
1975
Purification of cardiac myosin. Application to hypertrophied myocardium.
Biochimica et biophysica acta.
393(1):124-33
[PMID] 124593.
1971
Polyamine synthesis during initial phases of stress-induced cardiac hypertrophy.
The American journal of physiology.
221(5):1287-91
[PMID] 4256528.
1966
Lee Harvey Oswald: an Adlerian interpretation.
Psychoanalytic review.
53(3):55-68
[PMID] 5331258.
Contact Details
Phones:
- Business:
- (352) 262-7792
Emails:
- Business:
- kshiveri@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100267
GAINESVILLE FL 32610 - Business Street:
-
R5208 ARB
GAINESVILLE FL 32611