Mark S Moehle, Ph.D.
Assistant Professor
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About Mark S Moehle
Teaching Profile
Courses Taught
Research Profile
Visit moehlelab.org for the latest information on my lab!
The overarching goal of the Moehle Laboratory is to understand the cellular, molecular, and circuitry changes that underlie symptoms of neurological disorders. Using this deep understanding of changes to the brain in disease, we will be able to leverage these discoveries into novel therapeutic strategies for these diseases with large unmet clinical needs. Utilizing genetically, pharmacologically, and biochemically defined models of neurological disorders (such as dystonia, Parkinson’s Disease, and Dementias) we will perform cutting edge pharmacological, electrophysiological, behavioral, biochemical, and in vivo fiber photometry techniques to interrogate the cellular, molecular, and circuitry level changes in the central nervous system in these model systems. These studies have the possibility to make substantial advances in our understanding of brain wide changes in diseases such as Parkinson’s Disease, dystonia, and dementias as well as provide the pre-clinical rationale to direct larger drug discovery efforts for unique targets in these disorders.
0000-0002-8023-1313
Areas of Interest
- Dystonia
- Lewy Body Dementia
- Movement Disorders
- Muscarinic Acetylcholine Receptors
- Parkinson’s disease
Publications
Academic Articles
Grants
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Human alpha-synuclein templated pathology disruption of M2 cortex to striatum synaptic transmission and motor behaviors in Parkinsons disease
- Role:
- Principal Investigator
- Funding:
- FOX FOU, MICHAEL J
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Cholinergic Mechanisms in Lewy Body Dementia
Active
- Role:
- Principal Investigator
- Funding:
- NATL INST OF HLTH NINDS
-
Pathophysiology of DYT1 dystonia: Targeted Mouse Models
Active
- Role:
- Co-Investigator
- Funding:
- NATL INST OF HLTH NINDS
-
M5 modulators to treat or modify the motor symptoms of Parkinsons Disease
- Role:
- Principal Investigator
- Funding:
- FOX FOU, MICHAEL J
-
M4 muscarinic acetylcholine receptor signaling as a potent regulator of motor deficits
- Role:
- Principal Investigator
- Funding:
- NATL INST OF HLTH NINDS
-
Impact of aggregated a-synuclein on altering neuronal physiology and plasticity in vivo and ex vivo in relevant animal models of LBD
- Role:
- Principal Investigator
- Funding:
- UF FOUNDATION
-
Molecular Mechanisms of Hair Bundle Development and Maintenance
Active
- Role:
- Co-Investigator
- Funding:
- NATL INST OF HLTH NIDCD
-
Research Pharmacology IX
- Role:
- Project Manager
- Funding:
- UF FOUNDATION
Education
-
Postdoc
Vanderbilt University
-
Ph.D.
University of Alabama at Birmingham
-
B.S.
Centenary College of Louisiana
Contact Details
- Business:
- (352) 294-5571
- Business:
- mark.moehle@ufl.edu
- Business Mailing:
-
PO Box 100267
GAINESVILLE FL 32610