Philip J Scarpace, Ph.D.
Professor Emeritus
Department:
MD-PHARMACOLOGY / THERAPEUTICS
Business Phone:
(352) 328-6141
Business Email:
scarpace@ufl.edu
Teaching Profile
Courses Taught
2013-2015
GMS6417 Integrative Aging Physiology
2013-2014
BMS6031 Foundations of Med
2014
MDU4002 Introduction to Medical Science Seminar 2
2011-2014
DEN6262 Prin of Pharmacology
2008,2010-2012,2012
GMS7593 Topics in Pharmacology and Toxicology
2012
BMS4905 Medical Sciences Senior Research
Research Profile
The long-term goal of Garg’s research program was to understand the underlying mechanism of obesity, including both diet-induced and age-related obesity. Increased body weight is an important public health problem because it is associated with type II diabetes, hypertension and hyperlipidemia. His research focused on the mechanism of action of leptin and the role of leptin resistance in obesity. Leptin, synthesized by white adipose tissue (WAT), is an afferent signal molecule that interacts with the appetite and satiety centers in the brain to regulate body weight, and this hormone contributes to the regulation of both food intake and energy expenditure. His approach used both pharmacological and gene delivery techniques. He investigated the mechanism of action of leptin in young-lean animal compared with diet-induced obese rats and compared to aged-obese rats. His studies focused on leptin signal transduction in the hypothalamus and identifying downstream components of the leptin signal transduction cascade both in the brain and in peripheral tissues. In addition, his lab examined the site of leptin resistance with age or obesity by sequentially stimulating downstream elements of the leptin signal transduction cascade. Lastly, they attempted to reverse or prevent the development of obesity with diet or age with gene delivery techniques aimed at both circumventing the leptin resistance and independently activating energy expenditure mechanisms.
Publications
2018
ACE2 activator diminazene aceturate reduces adiposity but preserves lean mass in young and old rats.
Experimental gerontology.
111:133-140
[DOI] 10.1016/j.exger.2018.07.008.
[PMID] 30006298.
2018
Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction.
Canadian journal of physiology and pharmacology.
96(3):308-312
[DOI] 10.1139/cjpp-2017-0440.
[PMID] 29131966.
2018
iBAT sympathetic innervation is not required for body weight loss induced by central leptin delivery.
American journal of physiology. Endocrinology and metabolism.
314(3):E224-E231
[DOI] 10.1152/ajpendo.00219.2017.
[PMID] 29089334.
2018
Limiting feeding to the active phase reduces blood pressure without the necessity of caloric reduction or fat mass loss.
American journal of physiology. Regulatory, integrative and comparative physiology.
315(4):R751-R758
[DOI] 10.1152/ajpregu.00076.2018.
[PMID] 30024775.
2018
Oestradiol and leptin have separate but additive anorexigenic effects and differentially target fat mass in rats.
Journal of neuroendocrinology.
30(11)
[DOI] 10.1111/jne.12646.
[PMID] 30246441.
2018
Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum.
Behavioural brain research.
340:14-22
[DOI] 10.1016/j.bbr.2017.04.025.
[PMID] 28419850.
2017
Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction.
Canadian journal of physiology and pharmacology.
95(2):206-214
[DOI] 10.1139/cjpp-2016-0290.
[PMID] 28051332.
2017
Differential physiological responses to central leptin overexpression in male and female rats.
Journal of neuroendocrinology.
29(12)
[DOI] 10.1111/jne.12552.
[PMID] 29044801.
2017
Effect of High-Salt Diet on Age-Related High Blood Pressure and Hypothalamic Redox Signaling.
Pharmacology.
100(3-4):105-114
[DOI] 10.1159/000472259.
[PMID] 28521325.
2017
Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change STAT3 signalling or SIRT1/AMPK pathway.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
42(1):59-67
[DOI] 10.1139/apnm-2016-0067.
[PMID] 28006433.
2016
Age Impaired endothelium-dependent vasodilation is improved by resveratrol in rat mesenteric arteries.
Journal of exercise nutrition & biochemistry.
20(1):41-8
[DOI] 10.20463/jenb.2016.03.20.1.2.
[PMID] 27298812.
2016
Anorexic response to rapamycin does not appear to involve a central mechanism.
Clinical and experimental pharmacology & physiology.
43(9):802-7
[DOI] 10.1111/1440-1681.12601.
[PMID] 27232670.
2016
Fructose consumption does not worsen bone deficits resulting from high-fat feeding in young male rats.
Bone.
85:99-106
[DOI] 10.1016/j.bone.2016.02.004.
[PMID] 26855373.
2016
High dietary fructose does not exacerbate the detrimental consequences of high fat diet on basilar artery function.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
67(2):205-16
[PMID] 27226180.
2016
Onset of leptin resistance shows temporal differences related to dose or pulsed treatment.
European journal of pharmacology.
779:177-85
[DOI] 10.1016/j.ejphar.2016.03.026.
[PMID] 27012992.
2016
Protective effects of resveratrol on aging-induced cognitive impairment in rats.
Neurobiology of learning and memory.
131:131-6
[DOI] 10.1016/j.nlm.2016.03.022.
[PMID] 27040098.
2016
Rapamycin Normalizes Serum Leptin by Alleviating Obesity and Reducing Leptin Synthesis in Aged Rats.
The journals of gerontology. Series A, Biological sciences and medical sciences.
71(7):891-9
[DOI] 10.1093/gerona/glu230.
[PMID] 25617379.
2016
Rapamycin Versus Intermittent Feeding: Dissociable Effects on Physiological and Behavioral Outcomes When Initiated Early and Late in Life
Journals of Gerontology Series A-Biological Sciences and Medical Sciences.
71(7):866-875
[DOI] 10.1093/gerona/glu238.
[PMID] 25617380.
2015
Successful aging: Advancing the science of physical independence in older adults.
Ageing research reviews.
24(Pt B):304-27
[DOI] 10.1016/j.arr.2015.09.005.
[PMID] 26462882.
2015
The functional and structural changes in the basilar artery due to overpressure blast injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
35(12):1950-6
[DOI] 10.1038/jcbfm.2015.151.
[PMID] 26104291.
2014
Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia.
Journal of immunology (Baltimore, Md. : 1950).
192(12):6111-9
[DOI] 10.4049/jimmunol.1302895.
[PMID] 24829407.
2014
Overpressure Blast Injury Induced Structural and Functional Changes in the Brain and Basilar Artery
Journal of Neurotrauma.
31(12)
2014
Targeted leptin receptor blockade: role of ventral tegmental area and nucleus of the solitary tract leptin receptors in body weight homeostasis.
The Journal of endocrinology.
222(1):27-41
[DOI] 10.1530/JOE-13-0455.
[PMID] 24920667.
2014
The effects of aging on the functional and structural properties of the rat basilar artery.
Physiological reports.
2(6)
[DOI] 10.14814/phy2.12031.
[PMID] 24907295.
2014
The effects of enalapril and losartan on mechanical ventilation-induced sympathoadrenal activation and oxidative stress in rats.
The Journal of surgical research.
188(2):510-6
[DOI] 10.1016/j.jss.2014.01.054.
[PMID] 24630519.
2013
Dietary components in the development of leptin resistance.
Advances in nutrition (Bethesda, Md.).
4(2):164-75
[DOI] 10.3945/an.112.003152.
[PMID] 23493533.
2013
Leptin overexpression in VTA trans-activates the hypothalamus whereas prolonged leptin action in either region cross-desensitizes.
Neuropharmacology.
65:90-100
[DOI] 10.1016/j.neuropharm.2012.09.005.
[PMID] 22982569.
2013
Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla.
Neuroscience letters.
544:62-7
[DOI] 10.1016/j.neulet.2013.03.042.
[PMID] 23570732.
2012
Resveratrol Reverses Increased Hypothalamic Nadph Oxidase Activity and Vascular Dysfunction With Age
Gerontologist.
52:318-319
2012
Simultaneous introduction of a novel high fat diet and wheel running induces anorexia.
Physiology & behavior.
105(4):909-14
[DOI] 10.1016/j.physbeh.2011.11.011.
[PMID] 22115947.
2012
Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia.
The journals of gerontology. Series A, Biological sciences and medical sciences.
67(1):17-27
[DOI] 10.1093/gerona/glr042.
[PMID] 21636833.
2011
Effect of age on high-fat diet-induced hypertension.
American journal of physiology. Heart and circulatory physiology.
301(1):H164-72
[DOI] 10.1152/ajpheart.01289.2010.
[PMID] 21551274.
2011
POMC overexpression in the ventral tegmental area ameliorates dietary obesity.
The Journal of endocrinology.
210(2):199-207
[DOI] 10.1530/JOE-10-0418.
[PMID] 21565854.
2011
Prevention and reversal of diet-induced leptin resistance with a sugar-free diet despite high fat content.
The British journal of nutrition.
106(3):390-7
[DOI] 10.1017/S000711451100033X.
[PMID] 21418711.
2011
Region-specific diet-induced and leptin-induced cellular leptin resistance includes the ventral tegmental area in rats.
Neuropharmacology.
60(2-3):480-7
[DOI] 10.1016/j.neuropharm.2010.11.002.
[PMID] 21059361.
2011
Simultaneous POMC gene transfer to hypothalamus and brainstem increases physical activity, lipolysis and reduces adult-onset obesity.
The European journal of neuroscience.
33(8):1541-50
[DOI] 10.1111/j.1460-9568.2011.07633.x.
[PMID] 21366729.
2011
The act of voluntary wheel running reverses dietary hyperphagia and increases leptin signaling in ventral tegmental area of aged obese rats.
Gerontology.
57(4):335-42
[DOI] 10.1159/000321343.
[PMID] 20881371.
2010
Intermittent MTII application evokes repeated anorexia and robust fat and weight loss.
Peptides.
31(4):639-43
[DOI] 10.1016/j.peptides.2009.12.019.
[PMID] 20034526.
2010
Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity.
Neuroscience.
169(4):1662-71
[DOI] 10.1016/j.neuroscience.2010.06.001.
[PMID] 20538045.
2010
Wheel running eliminates high-fat preference and enhances leptin signaling in the ventral tegmental area.
Physiology & behavior.
100(2):173-9
[DOI] 10.1016/j.physbeh.2010.02.017.
[PMID] 20193697.
2009
Bilateral Nigral Raav5-Mediated Gdnf Over-Expression Activates Crh Neurons in the Paraventricular Nucleus of the Hypothalamus and Induces Robust Weight Loss in Obese Leptin-Resistant Rats
Molecular Therapy.
17
2009
Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis.
American journal of physiology. Regulatory, integrative and comparative physiology.
297(5):R1254-61
[DOI] 10.1152/ajpregu.90449.2008.
[PMID] 19726711.
2009
Effect of high-fat diet feeding on hypothalamic redox signaling and central blood pressure regulation.
Hypertension research : official journal of the Japanese Society of Hypertension.
32(11):983-8
[DOI] 10.1038/hr.2009.129.
[PMID] 19713964.
2009
Leptin resistance: a prediposing factor for diet-induced obesity.
American journal of physiology. Regulatory, integrative and comparative physiology.
296(3):R493-500
[DOI] 10.1152/ajpregu.90669.2008.
[PMID] 19091915.
2009
Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.
Molecular therapy : the journal of the American Society of Gene Therapy.
17(6):980-91
[DOI] 10.1038/mt.2009.45.
[PMID] 19277011.
2009
Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding.
The Journal of endocrinology.
203(2):281-90
[DOI] 10.1677/JOE-09-0210.
[PMID] 19679649.
2009
The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo.
British journal of pharmacology.
158(2):475-82
[DOI] 10.1111/j.1476-5381.2009.00246.x.
[PMID] 19422379.
2009
Weight Loss in Obese Leptin-Resistant Rats Induced By Activation of Crh Neurons in the Paraventricular Nucleus of the Hypothalamus By Overexpression of Substantial Nigral-Injected Raav5-Gdnf
Cell Transplantation.
18
2008
Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding.
American journal of physiology. Regulatory, integrative and comparative physiology.
295(5):R1370-5
[DOI] 10.1152/ajpregu.00195.2008.
[PMID] 18703413.
2008
Prolonged hyperphagia with high-fat feeding contributes to exacerbated weight gain in rats with adult-onset obesity.
American journal of physiology. Regulatory, integrative and comparative physiology.
295(3):R773-80
[DOI] 10.1152/ajpregu.00727.2007.
[PMID] 18596107.
2008
Synergy between leptin therapy and a seemingly negligible amount of voluntary wheel running prevents progression of dietary obesity in leptin-resistant rats.
Diabetes.
57(3):614-22
[PMID] 18086903.
2007
Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus.
Experimental gerontology.
42(8):745-52
[PMID] 17540525.
2007
Elevated leptin: consequence or cause of obesity?
Frontiers in bioscience : a journal and virtual library.
12:3531-44
[PMID] 17485319.
2007
Lean rats with hypothalamic pro-opiomelanocortin overexpression exhibit greater diet-induced obesity and impaired central melanocortin responsiveness.
Diabetologia.
50(7):1490-9
[PMID] 17505816.
2007
Leptin antagonist reveals an uncoupling between leptin receptor signal transducer and activator of transcription 3 signaling and metabolic responses with central leptin resistance.
The Journal of pharmacology and experimental therapeutics.
320(2):706-12
[PMID] 17082312.
2007
Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent.
American journal of physiology. Regulatory, integrative and comparative physiology.
292(2):R868-74
[PMID] 17023670.
2007
Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension.
Journal of hypertension.
25(12):2471-8
[PMID] 17984669.
2007
Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss.
American journal of physiology. Endocrinology and metabolism.
293(1):E252-8
[PMID] 17389713.
2006
Acute pressor effect of central angiotensin II is mediated by NAD(P)H-oxidase-dependent production of superoxide in the hypothalamic cardiovascular regulatory nuclei.
Journal of hypertension.
24(1):109-16
[PMID] 16331108.
2006
Circumventing central leptin resistance: lessons from central leptin and POMC gene delivery.
Peptides.
27(2):350-64
[PMID] 16274846.
2006
Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity.
Neurobiology of aging.
27(3):459-70
[PMID] 15964099.
2006
Oral vanadium enhances the catabolic effects of central leptin in young adult rats.
Endocrinology.
147(1):493-501
[PMID] 16195403.
2006
The role of leptin in leptin resistance and obesity.
Physiology & behavior.
88(3):249-56
[PMID] 16782141.
2005
Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats.
Diabetologia.
48(11):2376-85
[PMID] 16205885.
2005
Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats.
Diabetologia.
48(6):1075-83
[PMID] 15864530.
2004
Aged-obese rats exhibit robust responses to a melanocortin agonist and antagonist despite leptin resistance.
Neurobiology of aging.
25(10):1349-60
[PMID] 15465633.
2004
Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with diet-induced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression.
The Journal of endocrinology.
181(2):297-306
[PMID] 15128278.
2004
Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: microarray deoxyribonucleic acid-chip analysis of gene expression.
Endocrinology.
145(4):2035-45
[PMID] 14715713.
2004
Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression.
The Journal of endocrinology.
182(1):123-32
[PMID] 15225137.
2003
Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity.
American journal of physiology. Regulatory, integrative and comparative physiology.
285(5):R1011-20
[PMID] 14557234.
2003
Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats.
Diabetes.
52(8):1951-7
[PMID] 12882910.
2003
Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II.
Neuropharmacology.
45(2):211-9
[PMID] 12842127.
2003
Repeated fasting/refeeding elevates plasma leptin without increasing fat mass in rats.
Physiology & behavior.
78(3):459-64
[PMID] 12676282.
2003
Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats.
Proceedings of the National Academy of Sciences of the United States of America.
100(24):14217-22
[PMID] 14617771.
2002
Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats.
Neuropharmacology.
42(4):548-61
[PMID] 11955525.
2002
Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance.
Endocrinology.
143(8):3026-35
[PMID] 12130569.
2002
Metformin restores responses to insulin but not to growth hormone in Sprague-Dawley rats.
Biochemical and biophysical research communications.
291(3):722-6
[PMID] 11855850.
2001
An analysis of parotid salivary gland function with desipramine and age in female NIA Fischer 344 rats.
Experimental gerontology.
36(1):141-57
[PMID] 11162918.
2001
Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats.
Neuroscience.
104(4):1111-7
[PMID] 11457594.
2001
Mechanism for obesity-induced increase in myocardial lipid peroxidation.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.
25(3):378-88
[PMID] 11319636.
2001
Peripheral and hypothalamic leptin resistance with age-related obesity.
Physiology & behavior.
74(4-5):721-7
[PMID] 11790435.
2001
Transcriptional regulation of uncoupling protein-2 gene expression in L6 myotubes.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.
25(11):1619-24
[PMID] 11753581.
2000
An analysis of submandibular salivary gland function with desipramine and age in female NIA Fischer 344 rats.
Mechanisms of ageing and development.
119(3):131-47
[PMID] 11080533.
2000
Desipramine changes salivary gland function, oral microbiota, and oral health in rats.
European journal of pharmacology.
408(1):91-8
[PMID] 11070187.
2000
Impaired leptin responsiveness in aged rats.
Diabetes.
49(3):431-5
[PMID] 10868965.
2000
Impaired leptin signal transduction with age-related obesity.
Neuropharmacology.
39(10):1872-9
[PMID] 10884568.
2000
Modulation of uncoupling protein 2 and uncoupling protein 3: regulation by denervation, leptin and retinoic acid treatment.
The Journal of endocrinology.
164(3):331-7
[PMID] 10694373.
2000
Resistance to the anorexic and thermogenic effects of centrally administrated leptin in obese aged rats.
Regulatory peptides.
92(1-3):65-71
[PMID] 11024567.
2000
Uncoupling proteins 2 and 3 with age: regulation by fasting and beta3-adrenergic agonist treatment.
The journals of gerontology. Series A, Biological sciences and medical sciences.
55(12):B588-92
[PMID] 11129388.
1999
Beta3-adrenergic regulation of leptin, food intake, and adiposity is impaired with age.
Pflugers Archiv : European journal of physiology.
438(5):681-8
[PMID] 10555566.
1999
Dietary vitamin A supplementation in rats: suppression of leptin and induction of UCP1 mRNA.
Journal of lipid research.
40(5):824-9
[PMID] 10224151.
1999
Differential down-regulation of beta3-adrenergic receptor mRNA and signal transduction by cold exposure in brown adipose tissue of young and senescent rats.
Pflugers Archiv : European journal of physiology.
437(3):479-83
[PMID] 9914406.
1999
Induction of tyrosine hydroxylase and neuropeptide Y by carbachol: modulation with age.
The journals of gerontology. Series A, Biological sciences and medical sciences.
54(10):B418-23
[PMID] 10568524.
1998
Aging and fasting regulation of leptin and hypothalamic neuropeptide Y gene expression.
The American journal of physiology.
275(3):E405-11
[DOI] 10.1152/ajpendo.1998.275.3.E405.
[PMID] 9725806.
1998
Differential effects of retinoic acid on uncoupling protein-1 and leptin gene expression.
The Journal of endocrinology.
157(2):237-43
[PMID] 9659286.
1998
Leptin induction of UCP1 gene expression is dependent on sympathetic innervation.
The American journal of physiology.
275(2):E259-64
[DOI] 10.1152/ajpendo.1998.275.2.E259.
[PMID] 9688627.
1998
UCP2, UCP3 and leptin gene expression: modulation by food restriction and leptin.
The Journal of endocrinology.
159(2):349-57
[PMID] 9795377.
1997
AP-1 transcription factor binding activity in rat adrenal medulla and hypothalamus with age and cold exposure.
Neuropharmacology.
36(8):1065-9
[PMID] 9294971.
1997
beta 3-Adrenergic-mediated suppression of leptin gene expression in rats.
The American journal of physiology.
272(6 Pt 1):E1031-6
[PMID] 9227448.
1997
Induction of tyrosine hydroxylase by forskolin: modulation with age.
European journal of pharmacology.
324(1):57-62
[PMID] 9137913.
1997
Leptin gene expression increases with age independent of increasing adiposity in rats.
Diabetes.
46(12):2035-9
[PMID] 9392492.
1997
Leptin increases uncoupling protein expression and energy expenditure.
The American journal of physiology.
273(1 Pt 1):E226-30
[PMID] 9252501.
1997
Thermoregulation with age: role of beta-adrenergic signal transduction.
Annals of the New York Academy of Sciences.
813:111-6
[PMID] 9100870.
1996
Atypical pattern of adenylyl cyclase activity in the adrenal medulla with age.
Experimental gerontology.
31(5):571-6
[PMID] 9415112.
1996
Effects of age on beta adrenergic subtype activation of adenylyl cyclase in brown adipose tissue.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
213(3):262-7
[PMID] 8985310.
1996
Myocardial adenylyl cyclase type V and VI mRNA: differential regulation with age.
Journal of cardiovascular pharmacology.
27(1):86-90
[PMID] 8656664.
1996
Thermogenesis in brown adipose tissue with age: post-receptor activation by forskolin.
Pflugers Archiv : European journal of physiology.
431(3):388-94
[PMID] 8584432.
1996
Thermoregulation with age: restoration of beta(3)-adrenergic responsiveness in brown adipose tissue by cold exposure.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
211(4):374-80
[PMID] 8618944.
1994
Alpha 1-adrenergic and arginine vasopressin stimulation of inositide hydrolysis in rat hepatocytes is unaltered in senescence.
Journal of gerontology.
49(1):B18-21
[PMID] 8282972.
1994
Alpha-adrenergic receptor-mediated thermogenesis in brown adipose tissue of rat.
General pharmacology.
25(8):1703-10
[PMID] 7721049.
1994
Atypical beta-adrenergic receptors in rat liver: evidence for transient expression during aging.
Journal of gerontology.
49(2):B60-4
[PMID] 7907351.
1994
Effects of beta-adrenergic antagonists on salivary secretory function in individuals of different ages.
Journal of gerontology.
49(5):B208-14
[PMID] 7914526.
1994
Forskolin binding sites and G-protein immunoreactivity in rat hearts during aging.
Journal of cardiovascular pharmacology.
23(2):188-93
[PMID] 7511746.
1994
Influence of exercise training and age on uncoupling protein mRNA expression in brown adipose tissue.
Pharmacology, biochemistry, and behavior.
49(4):1057-9
[PMID] 7886075.
1994
Influence of exercise training on myocardial beta-adrenergic signal transduction: differential regulation with age.
Journal of applied physiology (Bethesda, Md. : 1985).
77(2):737-41
[PMID] 8002522.
1994
Relationship between cAMP production and protein secretion in rat submandibular acini: evidence for loss of reserve capacity with age.
Life sciences.
55(10):761-6
[PMID] 8072373.
1994
Thermoregulation with age: role of thermogenesis and uncoupling protein expression in brown adipose tissue.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
205(2):154-61
[PMID] 8108465.
1993
3,5,3′-L-triiodothyronine regulation of beta-adrenergic receptor density and adenylyl cyclase activity in synaptosomal membranes of aged rats.
Neuroscience letters.
161(1):101-4
[PMID] 8255534.
1993
Decreased sensitivity to cAMP in the in vitro generation of memory splenic cytotoxic T-lymphocytes from aged mice: role of phosphodiesterase.
The Journal of pharmacology and experimental therapeutics.
264(3):1381-6
[PMID] 8383747.
1993
Desipramine desensitizes beta-adrenergic signal transduction in salivary glands: differential regulation with age.
European journal of pharmacology.
247(1):65-72
[PMID] 8258362.
1993
Vasoactive properties of a parathyroid hormone-related protein in the rat aorta.
Peptides.
14(2):179-83
[PMID] 8387185.
1992
A biochemical analysis of parotid and submandibular salivary gland function with age after simultaneous stimulation with pilocarpine and isoproterenol in female NIA Fischer 344 rats.
Archives of oral biology.
37(3):219-30
[PMID] 1375022.
1992
Beta-adrenergic receptor activity of cerebral microvessels in experimental diabetes mellitus.
Brain research.
583(1-2):155-60
[PMID] 1324092.
1992
Beta-adrenergic receptors and salivary gland secretion during aging.
Growth, development, and aging : GDA.
56(4):215-23
[PMID] 1336769.
1992
Beta-adrenergic responsiveness in cultured aorta smooth muscle cells. Effects of subculture and aging.
Biochemical pharmacology.
43(8):1811-5
[PMID] 1315546.
1992
Desipramine desensitizes beta-adrenergic signal transduction in rat salivary glands.
Neuropharmacology.
31(12):1305-9
[PMID] 1335132.
1992
Geriatric pharmacology: basic and clinical considerations.
Annual review of pharmacology and toxicology.
32:271-302
[PMID] 1605569.
1992
Impaired febrile response with age: role of thermogenesis in brown adipose tissue.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
200(3):353-8
[PMID] 1615011.
1992
Influence of exercise and age on myocardial beta-adrenergic receptor properties.
Experimental gerontology.
27(2):169-77
[PMID] 1325922.
1992
The association of E. coli peritonitis with an impaired and delayed fever response in senescent rats.
Journal of gerontology.
47(4):B142-5
[PMID] 1624691.
1992
Thermogenesis and mitochondrial GDP binding with age in response to the novel agonist CGP-12177A.
The American journal of physiology.
262(2 Pt 1):E185-90
[PMID] 1539643.
1991
Adenylate cyclase agonist properties of CGP-12177A in brown fat: evidence for atypical beta-adrenergic receptors.
The American journal of physiology.
260(2 Pt 1):E226-31
[PMID] 1671733.
1991
Agonist-induced desensitization of liver alpha 1-receptors; implications for assessment of PI hydrolysis.
Second messengers and phosphoproteins.
13(2-3):131-9
[PMID] 1659634.
1991
Beta-adrenergic function in aging. Basic mechanisms and clinical implications.
Drugs & aging.
1(2):116-29
[PMID] 1665371.
1991
Beta-adrenergic receptor activity of cerebral microvessels is reduced in aged rats.
Neurochemical research.
16(4):447-51
[PMID] 1681437.
1991
Beta-adrenergic signal transduction in aging parotid and submandibular salivary glands.
Journal of gerontology.
46(6):B249-51
[PMID] 1658113.
1991
Escherichia coli peritonitis activates thermogenesis in brown adipose tissue: relationship to fever.
Canadian journal of physiology and pharmacology.
69(6):761-6
[PMID] 1655179.
1990
Alpha 1-adrenergic stimulation of inositide hydrolysis in liver of senescent rats.
Mechanisms of ageing and development.
56(3):275-80
[PMID] 1965214.
1990
Forskolin activation of adenylate cyclase in rat myocardium with age: effects of guanine nucleotide analogs.
Mechanisms of ageing and development.
52(2-3):169-78
[PMID] 2325432.
1990
Reduced alpha 1-adrenergic receptor-mediated inositide hydrolysis in cardiac atria of senescent rats.
Journal of cardiovascular pharmacology.
16(3):444-8
[PMID] 1700216.
1990
Reduced high-affinity alpha 1-adrenoceptors in liver of senescent rats: implications of assessment at various temperatures.
British journal of pharmacology.
101(3):650-4
[PMID] 1963803.
1989
The response to isoproterenol-stimulated adenylate cyclase activity after administration of L-triiodothyronine is reduced in aged rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
21(11):638-9
[PMID] 2591880.
1989
Viral pneumonia attenuates adenylate cyclase but not beta-adrenergic receptors in murine lung.
The American review of respiratory disease.
140(6):1602-6
[PMID] 2557784.
1988
Age-associated decrease in beta-adrenergic receptors and adenylate cyclase activity in rat brown adipose tissue.
Journal of gerontology.
43(3):B65-70
[PMID] 2834431.
1988
Alpha- and beta-adrenergic receptor function in the brain during senescence.
Neurobiology of aging.
9(1):53-8
[PMID] 2837671.
1988
Decreased receptor activation with age. Can it be explained by desensitization?
Journal of the American Geriatrics Society.
36(11):1067-71
[PMID] 2844878.
1988
Effect of age and posture on human lymphocyte adenylate cyclase activity.
Clinical science (London, England : 1979).
74(3):331-4
[PMID] 3345640.
1988
Glucocorticoids modulate beta-adrenoceptor subtypes and adenylate cyclase in brown fat.
The American journal of physiology.
255(2 Pt 1):E153-8
[PMID] 2841864.
1988
Increased beta-adrenergic receptors in the light-density membrane fraction in lungs from senescent rats.
Journal of gerontology.
43(6):B163-7
[PMID] 2846681.
1988
Relationship between behavioral and motor responses of mature and old mice and cerebellar beta-adrenergic receptor density.
Mechanisms of ageing and development.
45(3):231-7
[PMID] 2853259.
1988
The role of zinc status in altered cardiac adenylate cyclase activity in diabetic rats.
Acta endocrinologica.
119(2):174-80
[PMID] 2845690.
1987
Adenylate cyclase in senescence: catecholamine and parathyroid hormone pathways.
Reviews in clinical & basic pharmacology.
6(2):105-18
[PMID] 2821584.
1987
Characterization of beta-adrenergic receptors throughout the replicative life span of IMR-90 cells.
Journal of cellular physiology.
130(1):163-7
[PMID] 3027107.
1987
Diet restriction retards the age-related loss of beta-adrenergic receptors and adenylate cyclase activity in rat lung.
Journal of gerontology.
42(4):442-6
[PMID] 3036931.
1987
Modulation of receptors and adenylate cyclase activity during sucrose feeding, food deprivation, and cold exposure.
The American journal of physiology.
253(6 Pt 1):E629-35
[PMID] 2827501.
1986
Beta-adrenergic agonist-mediated desensitization in senescent rats.
Mechanisms of ageing and development.
35(3):255-64
[PMID] 2877123.
1986
Decreased beta-adrenergic responsiveness during senescence.
Federation proceedings.
45(1):51-4
[PMID] 3000835.
1986
Temperature and isoproterenol modulation of beta-adrenergic receptor characteristics.
Life sciences.
38(4):309-15
[PMID] 3003476.
1985
Characterization of the beta-adrenergic receptor of the rat peritoneal macrophage.
Journal of immunology (Baltimore, Md. : 1950).
135(2):1338-41
[PMID] 2409147.
1985
Cholesterol modulation of beta-adrenergic receptor characteristics.
Biochimica et biophysica acta.
845(3):520-5
[PMID] 2988644.
1985
Desensitization and resensitization of beta-adrenergic receptors in a smooth muscle cell line.
Molecular pharmacology.
28(6):495-501
[PMID] 2867463.
1984
The effect of age and cholesterol on the rat lung beta-adrenergic system.
Biochimica et biophysica acta.
778(3):497-502
[PMID] 6095909.
1983
Age-associated decrease in the catalytic unit activity of rat myocardial adenylate cyclase.
Mechanisms of ageing and development.
21(3-4):357-63
[PMID] 6310279.
1983
Decreased beta-adrenergic agonist affinity and adenylate cyclase activity in senescent rat lung.
Journal of gerontology.
38(2):143-7
[PMID] 6298302.
1983
The thermal lability of adenylate cyclase: mechanisms of stabilization.
Life sciences.
32(8):817-24
[PMID] 6681857.
1982
Catalytic unit of adenylate cyclase: reduced activity in aged-human lymphocytes.
The Journal of clinical endocrinology and metabolism.
55(5):1026-8
[PMID] 6889610.
1982
Desensitization of adenylate cyclase and down regulation of beta adrenergic receptors after in vivo administration of beta agonist.
The Journal of pharmacology and experimental therapeutics.
223(2):327-31
[PMID] 6127402.
1982
Isoproterenol responsiveness and myocardial beta-adrenergic receptors in young and old rats.
Journal of gerontology.
37(2):156-60
[PMID] 6276461.
1982
Lymphocyte beta-adrenergic refractoriness induced by theophylline or metaproterenol in healthy and asthmatic subjects.
Life sciences.
31(15):1567-73
[PMID] 6292641.
1982
Subsensitization of beta-adrenoceptors in airways and lymphocytes of healthy and asthmatic subjects.
The American review of respiratory disease.
125(2):185-93
[PMID] 6278998.
1981
Age-associated decrease of adenylate cyclase activity in rat myocardium.
Mechanisms of ageing and development.
16(1):91-5
[PMID] 6265716.
1981
Glucocorticoid regulation of myocardial beta-adrenergic receptors.
Endocrinology.
108(3):977-80
[PMID] 6257502.
1981
Human lymphocyte beta-adrenergic receptors are unaltered with age.
Journal of gerontology.
36(3):298-301
[PMID] 6262399.
1981
Thyroid hormone regulation of beta-adrenergic receptor number in aging rats.
Endocrinology.
108(4):1276-8
[PMID] 6258903.
1981
Thyroid hormone regulation of rat heart, lymphocyte, and lung beta-adrenergic receptors.
Endocrinology.
108(3):1007-11
[PMID] 6257494.
1978
The distribution of biologically active and inactive radioiodinated human calcitonin in the rat.
Endocrinology.
103(1):128-32
[PMID] 744063.
1977
Metabolism of radioiodinated salmon calcitonin in rats.
Endocrinology.
100(5):1260-7
[PMID] 849723.
1977
Preparation and immunological characteristics of biologically active radioiodinated human calcitonin.
Endocrinology.
101(5):1398-405
[PMID] 199416.
1976
The blood: bone disequilibrium. I. The active accumulation of K+ into the bone extracellular fluid.
Calcified tissue research.
(2):137-49
[PMID] 1260484.
1976
The blood: bone disequilibrium. II. Evidence against the active accumulation of calcium or phosphate into the bone extracellular fluid.
Calcified tissue research.
(2):151-8
[PMID] 1260485.
1973
Quantitation of Ca2+ fluxes in chick calvaria.
Biochimica et biophysica acta.
323(2):267-75
[PMID] 4796209.
Grants
Jul 2012
– Jun 2017
Mechanisms of diet-induced leptin resistance in ARC and VTA
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Contact Details
Phones:
- Business:
- (352) 328-6141
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- scarpace@ufl.edu
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