Holger Russ

Holger Russ,

ASO PROF

Department: MD-PHARMACOLOGY / THERAPEUTICS
Business Phone: (352) 294-5350
Business Email: holger.russ@ufl.edu

Teaching Profile

Courses Taught
2023
PAS5026 Pharmacotherapeu 2
2024
BMS6632 Endo and Reproduction
2024
GMS6009 Principles of Drug Action and Therapeutics
2024
GMS6560 Molecules to Man: Past, Present and Future Therapeutic Strategies for Disease
2024
DEN6262 Prin of Pharmacology

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-5117-2927

Publications

2024
Sox9 regulates alternative splicing and pancreatic beta cell function.
Nature communications. 15(1) [DOI] 10.1038/s41467-023-44384-8. [PMID] 38238288.
2023
A fast chemical reprogramming system promotes cell identity transition through a diapause-like state.
Nature cell biology. 25(8):1146-1156 [DOI] 10.1038/s41556-023-01193-x. [PMID] 37550515.
2023
Cell Replacement Therapy for Type 1 Diabetes Patients: Potential Mechanisms Leading to Stem-Cell-Derived Pancreatic β-Cell Loss upon Transplant
Cells. 12(5) [DOI] 10.3390/cells12050698. [PMID] 36899834.
2023
Enrichment of stem cell-derived pancreatic beta-like cells and controlled graft size through pharmacological removal of proliferating cells
Stem Cell Reports. 18(6):1284-1294 [DOI] 10.1016/j.stemcr.2023.05.010. [PMID] 37315522.
2023
Generation of functional thymic organoids from human pluripotent stem cells.
Stem cell reports. 18(4):829-840 [DOI] 10.1016/j.stemcr.2023.02.013. [PMID] 36963390.
2023
Nutrient-dependent regulation of β-cell proinsulin content.
The Journal of biological chemistry. 299(7) [DOI] 10.1016/j.jbc.2023.104836. [PMID] 37209827.
2023
Regulatory approval of islet transplantation for treatment of type 1 diabetes: Implications and what is on the horizon
Molecular Therapy. 31(11):3107-3108 [DOI] 10.1016/j.ymthe.2023.10.011. [PMID] 37865099.
2023
The beta cell-immune cell interface in type 1 diabetes (T1D).
Molecular metabolism. 78 [DOI] 10.1016/j.molmet.2023.101809. [PMID] 37734713.
2022
Emerging diabetes therapies: Bringing back the β-cells.
Molecular metabolism. 60 [DOI] 10.1016/j.molmet.2022.101477. [PMID] 35331962.
2022
From the dish to humans: A stem cell recipe for success.
Cell metabolism. 34(2):193-196 [DOI] 10.1016/j.cmet.2022.01.002. [PMID] 35108510.
2022
Generation of functional human thymic cells from induced pluripotent stem cells.
The Journal of allergy and clinical immunology. 149(2):767-781.e6 [DOI] 10.1016/j.jaci.2021.07.021. [PMID] 34331993.
2022
High-throughput identification of RNA localization elements in neuronal cells
Nucleic Acids Research. 50(18):10626-10642 [DOI] 10.1093/nar/gkac763. [PMID] 36107770.
2022
Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I.
Frontiers in endocrinology. 13 [DOI] 10.3389/fendo.2022.989815. [PMID] 36506044.
2022
Stem cell-based multi-tissue platforms to model human autoimmune diabetes.
Molecular metabolism. 66 [DOI] 10.1016/j.molmet.2022.101610. [PMID] 36209784.
2022
Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity
Cells. 11(23) [DOI] 10.3390/cells11233845. [PMID] 36497105.
2021
Amylin, Aβ42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells.
The Journal of infectious diseases. 223(7):1284-1294 [DOI] 10.1093/infdis/jiaa513. [PMID] 32809013.
2021
ENTPD3 Marks Mature Stem Cell–Derived β-Cells Formed by Self-Aggregation In Vitro
Diabetes. 70(11):2554-2567 [DOI] 10.2337/db20-0873. [PMID] 34380694.
2021
Found in Translation: Novel Insights Into Type 1 Diabetes and β-Cell Biology
Diabetes. 70(10):2185-2186 [DOI] 10.2337/dbi21-0031. [PMID] 34593539.
2021
In vitro generation of peri-islet basement membrane-like structures
Biomaterials. 273 [DOI] 10.1016/j.biomaterials.2021.120808. [PMID] 33895491.
2021
Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System.
Stem cell reports. 16(4) [DOI] 10.1016/j.stemcr.2021.03.006. [PMID] 33852882.
2021
Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors.
Frontiers in endocrinology. 12 [DOI] 10.3389/fendo.2021.622647. [PMID] 33841327.
2021
Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition.
Frontiers in endocrinology. 12 [DOI] 10.3389/fendo.2021.707881. [PMID] 34305820.
2021
Strategies for durable β cell replacement in type 1 diabetes
Science. 373(6554):516-522 [DOI] 10.1126/science.abh1657. [PMID] 34326233.
2021
Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes.
Frontiers in endocrinology. 12 [DOI] 10.3389/fendo.2021.737276. [PMID] 34858326.
2020
Author response: FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences
. [DOI] 10.7554/elife.52621.sa2.
2020
FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences
eLife. 9 [DOI] 10.7554/elife.52621.
2020
LIN28B Impairs the Transition of hESC-Derived β Cells from the Juvenile to Adult State.
Stem cell reports. 14(1):9-20 [DOI] 10.1016/j.stemcr.2019.11.009. [PMID] 31883920.
2020
Loss of the transcription factor MAFB limits β-cell derivation from human PSCs
Nature Communications. 11(1) [DOI] 10.1038/s41467-020-16550-9. [PMID] 32488111.
2020
Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System.
Stem cell reports. 14(6):1033-1043 [DOI] 10.1016/j.stemcr.2020.04.003. [PMID] 32386561.
2020
Varicella-Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-β, and an Amyloidogenic Extracellular Environment.
The Journal of infectious diseases. 221(7):1088-1097 [DOI] 10.1093/infdis/jiz560. [PMID] 31665341.
2019
Author Correction: Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.
Nature cell biology. 21(6) [DOI] 10.1038/s41556-019-0316-3. [PMID] 30914825.
2019
Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived β cells.
Nature cell biology. 21(2):263-274 [DOI] 10.1038/s41556-018-0271-4. [PMID] 30710150.
2019
Stem Cell Derived Organoids in Human Disease and Development.
Stem cells international. 2019 [DOI] 10.1155/2019/7919427. [PMID] 31827533.
2018
Replication confers β cell immaturity
Nature Communications. 9(1) [DOI] 10.1038/s41467-018-02939-0. [PMID] 29396395.
2018
β Cell replacement: improving on the design.
Current opinion in endocrinology, diabetes, and obesity. 25(4):251-257 [DOI] 10.1097/MED.0000000000000418. [PMID] 29846237.
2017
Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant.
Stem cell reports. 9(3):807-819 [DOI] 10.1016/j.stemcr.2017.07.012. [PMID] 28803916.
2017
Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy.
ACS nano. 11(8):7747-7757 [DOI] 10.1021/acsnano.7b01239. [PMID] 28763191.
2016
Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation.
Stem cells international. 2016 [DOI] 10.1155/2016/6183562. [PMID] 26681951.
2016
Human islets contain four distinct subtypes of β cells.
Nature communications. 7 [DOI] 10.1038/ncomms11756. [PMID] 27399229.
2016
Human pancreatic beta-like cells converted from fibroblasts.
Nature communications. 7 [DOI] 10.1038/ncomms10080. [PMID] 26733021.
2015
Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro.
The EMBO journal. 34(13):1759-72 [DOI] 10.15252/embj.201591058. [PMID] 25908839.
2015
Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro.
Scientific reports. 5 [DOI] 10.1038/srep13024. [PMID] 26264186.
2014
Dicer regulates differentiation and viability during mouse pancreatic cancer initiation.
PloS one. 9(5) [DOI] 10.1371/journal.pone.0095486. [PMID] 24788257.
2014
Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages.
Cell stem cell. 14(2):228-36 [DOI] 10.1016/j.stem.2014.01.006. [PMID] 24506886.
2014
Taming the young and restless–epigenetic gene regulation in pancreas and beta-cell precursors.
The EMBO journal. 33(19):2135-6 [DOI] 10.15252/embj.201489751. [PMID] 25154606.
2014
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma.
Nature cell biology. 16(3):255-67 [DOI] 10.1038/ncb2916. [PMID] 24561622.
2013
Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development.
Cell stem cell. 13(2):219-29 [DOI] 10.1016/j.stem.2013.04.004. [PMID] 23684540.
2012
Making β cells from adult tissues.
Trends in endocrinology and metabolism: TEM. 23(6):278-85 [DOI] 10.1016/j.tem.2012.03.005. [PMID] 22537825.
2012
Redifferentiation of expanded human pancreatic β-cell-derived cells by inhibition of the NOTCH pathway.
The Journal of biological chemistry. 287(21):17269-17280 [DOI] 10.1074/jbc.M111.319152. [PMID] 22457355.
2011
Development of human insulin-producing cells for cell therapy of diabetes.
Pediatric endocrinology reviews : PER. 9(2):590-7 [PMID] 22397143.
2011
Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells.
Cell stem cell. 9(1):17-23 [DOI] 10.1016/j.stem.2011.06.007. [PMID] 21726830.
2011
Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro.
PloS one. 6(9) [DOI] 10.1371/journal.pone.0025566. [PMID] 21984932.
2009
Epithelial-mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells.
PloS one. 4(7) [DOI] 10.1371/journal.pone.0006417. [PMID] 19641613.
2008
HES-1 is involved in adaptation of adult human beta-cells to proliferation in vitro.
Diabetes. 57(9):2413-20 [DOI] 10.2337/db07-1323. [PMID] 18599525.
2008
In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing.
Diabetes. 57(6):1575-83 [DOI] 10.2337/db07-1283. [PMID] 18316362.

Grants

Mar 2024 ACTIVE
Orthogonal engineering to suppress autoreactive T cell activation in T1D cell therapy
Role: Other
Funding: JDRF
Dec 2023 ACTIVE
Tolerance signals from human pregnancy for beta cell replacement therapy
Role: Principal Investigator
Funding: JDRF
Sep 2023 ACTIVE
Mechanistic analysis of TDP-43-mediated RNA localization in neurons and its misregulation in ALS
Role: Principal Investigator
Funding: UNIV OF COLORADO DENVER & ANSCHUTZ MED via NATL INST OF HLTH NINDS
May 2023 ACTIVE
Generating Stem Cell-Derived Beta-like Cells that Are Protected From Human Autoimmune Diabetes
Role: Principal Investigator
Funding: DIABETES RESEARCH CONNECTION
Apr 2023 ACTIVE
Engineered Nanocapsules for Targeted Drug Delivery to the ?-Cell
Role: Principal Investigator
Funding: COLORADO SCHOOL OF MINES via JDRF
Jan 2023 – Jul 2023
Engineered Nanocapsules for Targeted Drug Delivery to the ?-Cell
Role: Principal Investigator
Funding: COLORADO SCHOOL OF MINES via JDRF
Apr 2022 ACTIVE
Local immune modulation for beta cell replacement therapy in type 1 diabetes
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK

Contact Details

Phones:
Business:
(352) 294-5350
Emails:
Addresses:
Business Street:
ARB5-234
1200 Newell Drive
GAINESVILLE FL 32610