Samantha Perez-Miller

Samantha Perez-Miller,

Research Associate Scientist

Department: MD-PHARMACOLOGY / THERAPEUTICS
Business Phone: (352) 294-5350
Business Email: perezmiller.s@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9034-3693

Publications

2024
Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain.
Pain. 165(4):866-883 [DOI] 10.1097/j.pain.0000000000003080. [PMID] 37862053.
2023
A new polymodal gating model of the proton-activated chloride channel.
PLoS biology. 21(9) [DOI] 10.1371/journal.pbio.3002309. [PMID] 37713449.
2023
A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain.
Proceedings of the National Academy of Sciences of the United States of America. 120(47) [DOI] 10.1073/pnas.2305215120. [PMID] 37972067.
2023
Argentatin C Analogues with Potential Antinociceptive Activity and Other Triterpenoid Constituents from the Aerial Parts of Parthenium incanum.
ACS omega. 8(22):20085-20095 [DOI] 10.1021/acsomega.3c02302. [PMID] 37305315.
2023
Breast cancer therapies reduce risk of Alzheimer’s disease and promote estrogenic pathways and action in brain.
iScience. 26(11) [DOI] 10.1016/j.isci.2023.108316. [PMID] 38026173.
2023
Identification and targeting of a unique NaV1.7 domain driving chronic pain.
Proceedings of the National Academy of Sciences of the United States of America. 120(32) [DOI] 10.1073/pnas.2217800120. [PMID] 37498871.
2023
Targeting the vascular endothelial growth factor A/neuropilin 1 axis for relief of neuropathic pain.
Pain. 164(7):1473-1488 [DOI] 10.1097/j.pain.0000000000002850. [PMID] 36729125.
2023
The natural product argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels.
British journal of pharmacology. 180(9):1267-1285 [DOI] 10.1111/bph.15974. [PMID] 36245395.
2022
Stereospecific Effects of Benzimidazolonepiperidine Compounds on T-Type Ca2+ Channels and Pain.
ACS chemical neuroscience. 13(13):2035-2047 [DOI] 10.1021/acschemneuro.2c00256. [PMID] 35671441.
2022
The small molecule compound C65780 alleviates pain by stabilizing voltage-gated sodium channels in the inactivated and slowly-recovering state.
Neuropharmacology. 212 [DOI] 10.1016/j.neuropharm.2022.109057. [PMID] 35413303.
2021
Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells.
Stem cell reports. 16(10):2459-2472 [DOI] 10.1016/j.stemcr.2021.08.018. [PMID] 34525378.
2021
Comparison of quinazoline and benzoylpyrazoline chemotypes targeting the CaVα-β interaction as antagonists of the N-type CaV2.2 channel.
Channels (Austin, Tex.). 15(1):128-135 [DOI] 10.1080/19336950.2020.1863595. [PMID] 33416017.
2021
Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry.
ACS chemical neuroscience. 12(8):1299-1312 [DOI] 10.1021/acschemneuro.0c00619. [PMID] 33787218.
2021
SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia.
Pain. 162(1):243-252 [DOI] 10.1097/j.pain.0000000000002097. [PMID] 33009246.
2021
Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents.
Science translational medicine. 13(619) [DOI] 10.1126/scitranslmed.abh1314. [PMID] 34757807.
2020
A modulator of the low-voltage-activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies.
Pain. 161(11):2551-2570 [DOI] 10.1097/j.pain.0000000000001955. [PMID] 32541387.
2020
Druggability of CRMP2 for Neurodegenerative Diseases.
ACS chemical neuroscience. 11(17):2492-2505 [DOI] 10.1021/acschemneuro.0c00307. [PMID] 32693579.
2020
The role of cyclin-dependent kinase 5 in neuropathic pain.
Pain. 161(12):2674-2689 [DOI] 10.1097/j.pain.0000000000002027. [PMID] 32773603.
2019
Small Molecule Targeting TDP-43’s RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS).
ACS chemical biology. 14(9):2006-2013 [DOI] 10.1021/acschembio.9b00481. [PMID] 31241884.
2019
Structural Insights Into TDP-43 and Effects of Post-translational Modifications.
Frontiers in molecular neuroscience. 12 [DOI] 10.3389/fnmol.2019.00301. [PMID] 31920533.
2019
Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.
Pain. 160(7):1644-1661 [DOI] 10.1097/j.pain.0000000000001524. [PMID] 30933958.
2019
The Natural Flavonoid Naringenin Elicits Analgesia through Inhibition of NaV1.8 Voltage-Gated Sodium Channels.
ACS chemical neuroscience. 10(12):4834-4846 [DOI] 10.1021/acschemneuro.9b00547. [PMID] 31697467.
2018
A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).
ACS chemical biology. 13(10):3000-3010 [DOI] 10.1021/acschembio.8b00745. [PMID] 30141626.
2018
A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome.
Neuronal signaling. 2(3) [DOI] 10.1042/NS20180141. [PMID] 32714589.
2018
Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels.
Channels (Austin, Tex.). 12(1):219-227 [DOI] 10.1080/19336950.2018.1491244. [PMID] 30081699.
2018
Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.
British journal of pharmacology. 175(12):2244-2260 [DOI] 10.1111/bph.13737. [PMID] 28161890.
2018
Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain.
Pain. 159(10):2115-2127 [DOI] 10.1097/j.pain.0000000000001294. [PMID] 29847471.
2017
A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.
Channels (Austin, Tex.). 11(4):316-328 [DOI] 10.1080/19336950.2017.1299838. [PMID] 28277940.
2016
(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.
Molecular neurobiology. 53(3):1959-1976 [DOI] 10.1007/s12035-015-9141-2. [PMID] 25846820.
2013
Catalytic contribution of threonine 244 in human ALDH2.
Chemico-biological interactions. 202(1-3):32-40 [DOI] 10.1016/j.cbi.2012.12.009. [PMID] 23295226.
2013
Expression and purification of functional human glycogen synthase-1 (hGYS1) in insect cells.
Protein expression and purification. 90(2):78-83 [DOI] 10.1016/j.pep.2013.05.007. [PMID] 23711380.
2011
Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases.
The Journal of biological chemistry. 286(50):43486-94 [DOI] 10.1074/jbc.M111.293597. [PMID] 22021038.
2010
Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.
Nature structural & molecular biology. 17(2):159-64 [DOI] 10.1038/nsmb.1737. [PMID] 20062057.
2010
High resolution X-ray structures of mouse major urinary protein nasal isoform in complex with pheromones.
Protein science : a publication of the Protein Society. 19(8):1469-79 [DOI] 10.1002/pro.426. [PMID] 20509168.
2007
Light chain C-terminal region reinforces the stability of clathrin heavy chain trimers.
Traffic (Copenhagen, Denmark). 8(8):1101-10 [PMID] 17555534.
2003
Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase.
Biochemistry. 42(23):7100-9 [PMID] 12795606.
2001
Order and disorder in mitochondrial aldehyde dehydrogenase.
Chemico-biological interactions. 130-132(1-3):3-14 [PMID] 11306026.
2001
Three-dimensional structures of the three human class I alcohol dehydrogenases.
Protein science : a publication of the Protein Society. 10(4):697-706 [PMID] 11274460.

Contact Details

Phones:
Business:
(352) 294-5350
Emails:
Addresses:
Business Street:
PO Box 100267
GAINESVILLE FL 32610