Roger L Papke

Roger L Papke, Ph.D.

PROFESSOR

Department: MD-PHARMACOLOGY / THERAPEUTICS
Business Phone: (352) 392-4712
Business Email: rlpapke@ufl.edu

Honors & Awards

Exemplary Teacher
2016 · UF College of Medicine
Co-recipient of R&D 100
2004 · R&D 100 Conference
Top Ten Basic Science Faculty
2002 · UF College of Medicine

Research Profile

The Papke Lab studies the physiology, pharmacology, and biophysics of neurotransmitter receptors with a special emphasis on the function of nicotinic acetylcholine receptors in the brain. These are the receptors that mediate the effects of nicotine on human behavior. The lab studies how these neuronal nicotinic acetylcholine receptors function as ligand-gated ion channels, identifying parts of the molecule that are involved with the binding of neurotransmitter and the conformational change associated with receptor activation. The lab is also characterizing the selectivity of experimental nicotinic agonists for specific receptor subtypes in the brain. With this understanding, they hope to identify the mechanisms through which nicotine-like substances may alleviate some of the learning and memory impairments in animal models of dementia. The ongoing clinical development of new experimental drugs may lead to novel therapeutics for the treatment of Alzheimer’s disease.

Areas of Interest
  • Nicotine Addiction
  • Smoking Cessation

Publications

2018 The Journal of pharmacology and experimental therapeutics
2009 Journal of Pharmacology and Experimental Therapeutics
2009 Combinatorial Chemistry and High Throughput Screening
2009 Combinatorial Chemistry and High Throughput Screening
2009 Bioorganic & Medicinal Chemistry Letters
2001 Journal of Pharmacology and Experimental Therapeutics

Patents

Issued November 1999
Cinnamylidene Anabaseine Compounds For Brain Disorders
#5,977,144
Issued February 2005
Compositions and Methods for Treatment of Neurological Disorders
#6,852,741
Published November 2008
Selective Inhibitors of Neuronal Nicontic Acetylcholine Receptors(DIV)
#US-2009-0062339-A1
Issued May 2009
Compositions and Methods for Selective Inhibition of Nicotine Acetylcholine Receptors
#7,531,555
Published October 2009
Use of a Novel a7 nAChR Antagonist to Treat Cancer and AIDs
#2010-0179186
Issued March 2015
Compositions and Methods for Selective Inhibition of Nicotine Acetylcholine Receptors (DIV of 10282
#8,980,923
Issued January 2016
Therapies to Improve Smoking Cessation in Neuropsychiatric and Depressed Patients
#9,233,109
Published April 2018
Nicotinic Acetylcholine Receptor Silent Agonists
#US-2018-0298002-A1

Contact Details

Phones:
Business:
(352) 392-4712
Emails:
Business:
rlpapke@ufl.edu