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Department of Pharmacology & Therapeutics College of Medicine
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Aline C Oliveira

Aline C Oliveira, Ph.D.

Assistant Professor

Department: MD-PHARMACOLOGY – THERAPEUTICS
Business Phone: (352) 273-9432
Business Email: aline.oliveira@ufl.edu
CV: View Curriculum Vitae

On This Page

Accomplishments

  1. 2nd Place – Early Career Showcase

    CICMD – University of Florida

  2. 2nd Place – Early Career Showcase

    CICMD – University of Florida

  3. Postdoctoral Fellowship

    American Heart Association

  4. Postdoctoral Fellowship (relinquished)

    American Physiology Society

  5. Best Poster Award

    American Heart Association – Council on Hypertension

  6. Training Enhancement Opportunity Award

    MBI – University of Florida

  7. 2nd place in Eduardo Krieger Award in Basic Research

    XXII Conference of Brazilian Society of Hypertension and XX Scientific session of the Interamerican Society of Hypertension.

  8. Travel Award

    XX InterAmerican Society of Hypertension

Research Profile

In the Oliveira Lab we are dedicated to understanding the brain’s pathogenic contribution to cardiopulmonary diseases, with a particular emphasis on pulmonary hypertension (PH). Our research aims to identify innovative therapeutic targets that could transform the current treatment for this debilitating condition.

Pulmonary hypertension (PH) is a progressive disease that affects the lung vasculature leading to right heart failure and an unacceptably high mortality rate. Despite major advances in our understanding of the pathophysiology, to date, we still have limited mechanistic insight into PH development and progression. Thus, despite advances in current therapies, there is no available cure and treatment has limited improvement in outcome. Therefore, there is an urgent need for novel therapeutic approaches.

Our research has highlighted a critical role for activated microglia in neuroinflammation within key autonomic brain regions, especially the paraventricular nucleus (PVN) of the hypothalamus. Our findings led us to hypothesize that activation of resident microglia and infiltrated myeloid precursors, promotes aberrant preautonomic neuronal signaling in the paraventricular nucleus of the hypothalamus contributing to sustained sympathetic activation, which is critical to PH.

To address these vital questions, we employ cutting-edge neuroscience techniques alongside established pulmonary hemodynamic and histological analyses. Our methodology includes live cell imaging in brain slices, right heart catheterization, and immunohistochemistry, complemented by validation studies in human tissues and cells.

Through this interdisciplinary approach, we aim to understand the brain’s pathogenic contributions to pulmonary hypertension and pave the way for groundbreaking therapeutic strategies that could improve patient outcomes.

Publications

Academic Articles

Grants

  1. Neuroimmune axis contribution to the pathophysiology of pulmonary hypertension

    Active

    Role:
    Principal Investigator
    Funding:
    NATL INST OF HLTH NHLBI

  2. Neuroimmune axis contribution to the pathophysiology of pulmonary hypertension

    Role:
    Principal Investigator
    Funding:
    NATL INST OF HLTH NHLBI

  3. Involvement of Neuroinflammation in Pulmonary Hypertension

    Role:
    Principal Investigator
    Funding:
    AMER HEART ASSOCIATION

Education

  1. PhD in Physiology

    Federal University of Minas Gerais

  2. MSc in Physiology

    Federal University of Minas Gerais

  3. Bachelor in Physiotherapy

    Pontifical Catholic University of Minas Gerais

Contact Details

Phones:
Business:
(352) 273-9432
Emails:
Business:
aline.oliveira@ufl.edu
Addresses:
Business Mailing:
PO Box 100267
 GAINESVILLE FL 32610
Business Street:
PO Box 100267
1200 NEWELL DR
 GAINESVILLE FL 32610