Tyler S Nelson, Ph.D.
Research Assistant Scientist
Department:
MD-PHARMACOLOGY / THERAPEUTICS
Business Email:
tylernelson@ufl.edu
Accomplishments
Mitchell Max Award for Research Excellence
2023
·
NIH Pain Consortium
Research Profile
Dr. Tyler Nelson received his PhD in Neurobiology from the University of Pittsburgh School of Medicine as a trainee in the Pittsburgh Center for Pain Research. Tyler’s doctoral research focused on the spinal cord dorsal horn microcircuitry underlying neuropathic pain, with a focus on neuropeptide Y – Y1 signaling. His doctoral work was supported by multiple grants from the National Institute for Neurological Disorders and Stroke (NINDS), including a T32, an F32, and an F99. Dr. Nelson studies the peripheral and central mechanisms of neuropathic and neuromuscular pain using a combination of molecular, genetic, electrophysiological, and behavioral approaches. Tyler is currently funded by a K00 award focused on dissecting the parabrachial nucleus’s role in the manifestation and maintenance of neuropathic pain, and a development grant from the American Neuromuscular Foundation focused on pain mechanisms in the periodic paralyses.
Publications
Academic Articles
2024
A parabrachial hub for the prioritization of survival behavior.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.02.26.582069.
[PMID] 38464066.
2024
Mouse models of non-dystrophic and dystrophic myotonia exhibit nociplastic pain-like behaviors.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.06.19.599732.
[PMID] 38948724.
2024
Neuropeptide Y Y2 Receptors in Sensory Neurons Tonically Suppress Nociception and Itch but Facilitate Postsurgical and Neuropathic Pain Hypersensitivity.
Anesthesiology.
141(5):946-968
[DOI] 10.1097/ALN.0000000000005184.
[PMID] 39121458.
2024
Parabrachial Calca neurons drive nociplasticity.
Cell reports.
43(4)
[DOI] 10.1016/j.celrep.2024.114057.
[PMID] 38583149.
2024
Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain.
Pain.
165(4):866-883
[DOI] 10.1097/j.pain.0000000000003080.
[PMID] 37862053.
2024
The spino-parabrachio-amygdaloid pathway is critical for the manifestation of chronic pain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
49(3):491-492
[DOI] 10.1038/s41386-023-01745-7.
[PMID] 37740055.
2024
Uncoupling the CRMP2-CaV2.2 Interaction Reduces Pain-Like Behavior in a Preclinical Joint-Pain Model.
The journal of pain.
25(12)
[DOI] 10.1016/j.jpain.2024.104664.
[PMID] 39233208.
2024
Uncoupling the CRMP2-CaV2.2 interaction reduces pain-like behavior in a preclinical osteoarthritis model.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.06.05.596514.
[PMID] 38895294.
2023
A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain.
Proceedings of the National Academy of Sciences of the United States of America.
120(47)
[DOI] 10.1073/pnas.2305215120.
[PMID] 37972067.
2023
Alleviation of neuropathic pain with neuropeptide Y requires spinal Npy1r interneurons that coexpress Grp.
JCI insight.
8(22)
[DOI] 10.1172/jci.insight.169554.
[PMID] 37824208.
2023
Contribution of µ Opioid Receptor-expressing Dorsal Horn Interneurons to Neuropathic Pain-like Behavior in Mice.
Anesthesiology.
139(6):840-857
[DOI] 10.1097/ALN.0000000000004735.
[PMID] 37566700.
2023
Endogenous μ-opioid-Neuropeptide Y Y1 receptor synergy silences chronic postoperative pain in mice.
PNAS nexus.
2(8)
[DOI] 10.1093/pnasnexus/pgad261.
[PMID] 37649580.
2023
Neuropilin-1 is essential for vascular endothelial growth factor A-mediated increase of sensory neuron activity and development of pain-like behaviors.
Pain.
164(12):2696-2710
[DOI] 10.1097/j.pain.0000000000002970.
[PMID] 37366599.
2023
Parabrachial Calca neurons drive nociplasticity.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.10.26.564223.
[PMID] 37961621.
2023
The Emerging Translational Potential of MNK Inhibitors for the Treatment of Chronic Pain.
Neuroscience.
515:93-95
[DOI] 10.1016/j.neuroscience.2023.02.009.
[PMID] 36922084.
2022
Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain.
Proceedings of the National Academy of Sciences of the United States of America.
119(46)
[DOI] 10.1073/pnas.2204515119.
[PMID] 36343228.
2021
Targeting spinal neuropeptide Y1 receptor-expressing interneurons to alleviate chronic pain and itch.
Progress in neurobiology.
196
[DOI] 10.1016/j.pneurobio.2020.101894.
[PMID] 32777329.
2020
Behavioral and neurophysiological taste responses to sweet and salt are diminished in a model of subclinical intestinal inflammation.
Scientific reports.
10(1)
[DOI] 10.1038/s41598-020-74632-6.
[PMID] 33077838.
2019
An NPY Y1 receptor antagonist unmasks latent sensitization and reveals the contribution of protein kinase A and Epac to chronic inflammatory pain.
Pain.
160(8):1754-1765
[DOI] 10.1097/j.pain.0000000000001557.
[PMID] 31335645.
2019
Dorsal Horn PKCγ Interneurons Mediate Mechanical Allodynia through 5-HT2AR-Dependent Structural Reorganization.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
39(32):6221-6223
[DOI] 10.1523/JNEUROSCI.0291-19.2019.
[PMID] 31391259.
2019
Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn.
Scientific reports.
9(1)
[DOI] 10.1038/s41598-019-43493-z.
[PMID] 31076578.
2019
Selective stimulation of central GABAAα2,3,5 receptors increases intake and motivation to consume sucrose solution in rats.
Neuroscience.
409:111-119
[DOI] 10.1016/j.neuroscience.2019.04.040.
[PMID] 31047979.
2018
Estrogen Receptor β Agonist Attenuates Endoplasmic Reticulum Stress-Induced Changes in Social Behavior and Brain Connectivity in Mice
Molecular Neurobiology.
55(9):7606-7618
[DOI] 10.1007/s12035-018-0929-8.
[PMID] 29430617.
Grants
Apr 2024
ACTIVE
Dissecting the Parabrachial Nucleuss Role in the Development and Maintenance of Neuropathic Pain
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jan 2024
ACTIVE
Analysis of a Novel Primary Periodic Paralysis SCN4A Mutation with Pain as a Major Phenotype
Role: Principal Investigator
Funding: American Neuromuscular Foundation
Education
PhD- Neurobiology
2022
·
University of Pittsburgh School of Medicine
BA-German
2016
·
Wofford College
BS- Biology
2016
·
Wofford College
Contact Details
Emails:
- Business:
- tylernelson@ufl.edu
Addresses:
- Business Street:
-
PO Box 100267
GAINESVILLE FL 32610