Allen H Neims

Allen H Neims,

Professor Emeritus

Department: MD-PHARMACOLOGY / THERAPEUTICS
Business Phone: (352) 392-0687
Business Email: ahneims@ufl.edu

Teaching Profile

Courses Taught
2012
DEN6262 Prin of Pharmacology
2006-2007
REL4936 Special Topics in Religious Studies
2006-2007
REL5937 Top Relig Studies
2006-2007
SYA4930 Special Study
2006-2007
SYA5933 Special Study

Research Profile

Neims is interested in the full range of factors that influence the outcome of therapy. As such, he is interested the importance of the physician-patient relationship in the healing process, individual differences in response, complementary and alternative medical practices, the synergy between ‘healing’ and ‘curing’, and the maintenance of wellness. In a more standard scientific way, he is interested in exploring the challenges intrinsic to the application of tradition scientific paradigms, especially in clinical research, to assessment of various complementary practices. Outcome measures, risk assessment and epidemiology play important roles in this process. Neims is paricularly interested in this regard in bridging traditional pharmacotherapy and other therapeutic modalities, in pursuit of mechanism and enhanced efficacy. Finally, he is involved in application of these ideas in medical education and continuing medical education.

(SOURCE: UF Center for Spirituality and Health, http://www.spiritualityandhealth.ufl.edu/directorsadvisors/neims.asp)

Publications

1999
Why I would recommend complementary or alternative therapies: a physician’s perspective.
Rheumatic diseases clinics of North America. 25(4):845-53, vii [PMID] 10573761.
1998
Lifetime use of alternative therapy: a study of Florida residents.
Southern medical journal. 91(12):1126-31 [PMID] 9853724.
1998
Moving a graveyard: how one school prepared the way for continuous curriculum renewal.
Academic medicine : journal of the Association of American Medical Colleges. 73(9):948-55 [PMID] 9759096.
1998
Personal use of alternative medicine therapies by health science center faculty.
JAMA. 280(18) [PMID] 9820248.
1995
The interface between traditional and alternative medicine.
Alternative therapies in health and medicine. 1(4) [PMID] 9419805.
1994
Medical schools on the fault line.
The Journal of the Florida Medical Association. 81(3):165-6 [PMID] 8195770.
1993
4-Quinolones cause a selective loss of mitochondrial DNA from mouse L1210 leukemia cells.
Journal of cellular biochemistry. 51(2):165-74 [PMID] 8440750.
1993
Generalist physicians.
The Journal of the Florida Medical Association. 80(2):97-8 [PMID] 8455016.
1992
Winners of the 1992 Teaching Awards.
The Journal of the Florida Medical Association. 79(6) [PMID] 1640204.
1988
Relative efficacy of phenytoin and phenobarbital for the prevention of theophylline-induced seizures in mice.
Annals of emergency medicine. 17(10):1024-8 [PMID] 3177989.
1988
Synthetic polyamine analogues as antineoplastics.
Journal of medicinal chemistry. 31(6):1183-90 [PMID] 3373487.
1987
Mitochondrial DNA damage by bleomycin.
Biochemical pharmacology. 36(17):2769-74 [PMID] 2443143.
1986
Identification of children for whom routine monitoring of aminoglycoside serum concentrations is not cost effective.
The Journal of pediatrics. 109(5):897-901 [PMID] 3095524.
1986
Individuality in the response to dietary constituents: some lessons from drugs.
Nutrition reviews. 44 Suppl:237-41 [PMID] 2980854.
1986
Nitrofurantoin inhibition of mouse liver mitochondrial respiration involving NAD-linked substrates.
Toxicology and applied pharmacology. 84(3):493-9 [PMID] 3726872.
1985
A method for assessing damage to mitochondrial DNA caused by radiation and epichlorohydrin.
Molecular pharmacology. 27(1):167-70 [PMID] 3965928.
1984
Behavioral effects of caffeine in children. Relationship between dietary choice and effects of caffeine challenge.
Archives of general psychiatry. 41(11):1073-9 [PMID] 6497569.
1984
Regulation of microsomal testosterone 15 alpha-hydroxylase activity in inbred mouse liver and kidney.
Biochemical Society transactions. 12(1):45-8 [PMID] 6705987.
1984
Report of Fourth International Caffeine Workshop, Athens, 1982.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 22(2):163-9 [PMID] 6141987.
1983
High intravenous phenytoin dosage requirement in a newborn infant.
Neurology. 33(1):106-8 [PMID] 6681550.
1983
Maturation of various testosterone hydroxylase activities in hepatic microsomes from AKR/J mice.
Progress in clinical and biological research. 135:25-35 [PMID] 6665006.
1983
Metabolism of caffeine by mouse liver microsomes: GSH or cytosol causes a shift in products from 1,3,7-trimethylurate to a substituted diaminouracil.
Life sciences. 33(12):1173-8 [PMID] 6888171.
1983
Methyl mercury exposure in northern Quebec. II. Neurologic findings in children.
American journal of epidemiology. 118(4):470-9 [PMID] 6637974.
1982
The elimination of bilirubin.
Mead Johnson Symposium on Perinatal and Developmental Medicine. (19):9-12 [PMID] 6821468.
1982
Theophylline doses in The Harriet Lane Handbook.
American journal of hospital pharmacy. 39(5) [PMID] 7081249.
1981
Behavioral and autonomic effects of caffeine in normal boys.
Developmental pharmacology and therapeutics. 3(2):74-82 [PMID] 7318640.
1981
Behavioral and cognitive effects of caffeine in boys and adult males.
The Journal of nervous and mental disease. 169(11):726-32 [PMID] 7299385.
1981
Prolonged half-life of caffeine in healthy tem newborn infants.
The Journal of pediatrics. 98(4):640-1 [PMID] 7205496.
1981
The disposition of caffeine during and after pregnancy.
Seminars in perinatology. 5(4):310-4 [PMID] 7302604.
1981
The need for a longitudinal plan in teaching clinical pharmacology.
Journal of clinical pharmacology. 21(5-6):258-9 [PMID] 7263920.
1980
Relationship between the clearance of caffeine and its 7-N-demethylation in developing beagle puppies.
Biochemical pharmacology. 29(13):1909-14 [PMID] 7396998.
1979
Caffeine metabolism in the newborn.
Clinical pharmacology and therapeutics. 25(4):447-53 [PMID] 428190.
1979
Multiple forms of ethoxyresorufin O-de-ethylase and benzphetamine N-demethylase in solubilized and partially resolved rat liver cytochromes P-450.
Drug metabolism and disposition: the biological fate of chemicals. 7(3):188-93 [PMID] 38092.
1979
Multiplicity of testosterone hydroxylases in a reconstituted hepatic cytochrome P-450 system from uninduced male rats.
Drug metabolism and disposition: the biological fate of chemicals. 7(5):290-5 [PMID] 40768.
1979
Pharmacokinetic profile of caffeine in the premature newborn infant with apnea.
The Journal of pediatrics. 94(4):663-8 [PMID] 430317.
1979
The effects of phenobarbital and beta-naphthoflavone on the elimination kinetics and metabolite pattern of caffeine in the beagle dog.
Drug metabolism and disposition: the biological fate of chemicals. 7(6):378-82 [PMID] 43223.
1978
Chromatographic and electrophoretic heterogeneity of the cytochromes P-450 solubilized from untreated rat liver.
Drug metabolism and disposition: the biological fate of chemicals. 6(4):353-62 [PMID] 80314.
1978
Effect of smoking on caffeine clearance.
Clinical pharmacology and therapeutics. 24(1):40-5 [PMID] 657717.
1978
Isoelectric focusing of glutathione S-transferases from rat liver and kidney.
The Biochemical journal. 175(3):937-43 [PMID] 743240.
1977
Alteration of ovine fetal respiratory-like activity by diazepam, caffeine, and doxapram.
American journal of obstetrics and gynecology. 127(1):43-9 [PMID] 831485.
1977
Hog cerebellar D-amino acid oxidase and its histochemical and immunofluorescent localization.
Journal of neurochemistry. 28(3):559-72 [PMID] 16084.
1977
Induction of rat hepatic glutathione S-transferase B by phenobarbital and 3-methylcholanthrene.
Biochemical pharmacology. 26(6):555-6 [PMID] 849356.
1977
Pharmacokinetic observations of phenytoin disposition in the newborn and young infant.
Archives of disease in childhood. 52(4):302-9 [PMID] 871217.
1977
Stimulation of caffeine metabolism in the rat by 3-methylcholanthrene.
Life sciences. 21(7):967-74 [PMID] 927023.
1977
The development of D-amino acid oxidase in rat cerebellum.
Journal of neurochemistry. 29(4):649-56 [PMID] 22582.
1977
The effect of birth on the maturation of hepatic cytochrome(s) P-450 mono-oxygenase and tyrosine aminotransferase activities in the guinea pig.
Biology of the neonate. 31(3-4):213-8 [PMID] 16670.
1977
The effects of postnatal hyper- and hypothyroidism on the development of D-amino acid oxidase in rat cerebellum and brain stem.
Brain research. 138(1):139-50 [PMID] 22391.
1976
A sex difference in hepatic glutathione S-transferase B and the effect of hypophysectomy.
The Biochemical journal. 160(2):223-9 [PMID] 827287.
1976
Developmental aspects of glutathione S-transferase B (ligandin) in rat liver.
The Biochemical journal. 160(2):231-6 [PMID] 1008852.
1976
Developmental aspects of the hepatic cytochrome P450 monooxygenase system.
Annual review of pharmacology and toxicology. 16:427-45 [PMID] 820239.
1976
Drug utilization in a newborn intensive care unit.
The Journal of pediatrics. 89(2):315-7 [PMID] 940033.
1976
Pharmacokinetic analysis of the disposition of intravenous theophylline in young children.
The Journal of pediatrics. 88(5):874-9 [PMID] 1271155.
1976
Pharmacokinetic aspects of theophylline in premature newborns.
The New England journal of medicine. 295(8):413-6 [PMID] 934239.
1976
The presence of EDTA in commercial preparations of isocitrate dehydrogenase.
Biochemical pharmacology. 25(12):1436-7 [PMID] 820353.
1976
The two-compartment open-system kinetic model: a review of its clinical implications and applications.
The Journal of pediatrics. 88(5):869-73 [PMID] 1271154.
1975
Studies on Z-Fraction. I. Isolation and partial characterization of low molecular weight ligand-binding protein from rat hepatic cytosol.
Canadian journal of physiology and pharmacology. 53(3):493-500 [PMID] 807304.
1973
D-aspartate oxidase in mammalian brain and choroid plexus.
Journal of neurochemistry. 21(4):1037-9 [PMID] 4148237.
1973
Pharmacokinetic studies of trimethoprim-sulfamethoxazole in children with gastroenteritis.
The Journal of infectious diseases. 128:Suppl:622-5 p [PMID] 4271306.
1972
Anticonvulsant properties of the ketogenic diet in mice.
The Journal of pharmacology and experimental therapeutics. 180(2):231-8 [PMID] 5010672.
1970
Flavoenzyme catalysis.
Annual review of biochemistry. 39:867-88 [PMID] 4394638.
1966
A sensitive radioassay for sulfhydryl groups with tetraethylthiuram disulfide.
The Journal of biological chemistry. 241(13):3036-40 [PMID] 4380392.
1966
Distribution of D-amino acid oxidase in bovine and human nervous tissues.
Journal of neurochemistry. 13(3):163-8 [PMID] 4380208.
1966
Interaction between tetraethylthiuram disulfide and the sulfhydryl groups of D-amino acid oxidase and of hemoglobin.
The Journal of biological chemistry. 241(24):5941-8 [PMID] 4380934.
1966
Studies on crystalline D-amino acid oxidase. 3. Substrate specificity and sigma-rho relationship.
Biochemistry. 5(1):203-12 [PMID] 4380071.
1965
STUDIES ON CRYSTALLINE D-AMINO ACID OXIDASE. I. SELECTIVE INHIBITION IN THE ACTION OF SULFHYDRYL-BINDING REAGENTS.
The Journal of biological chemistry. 240:290-8 [PMID] 14253426.
1965
Studies on crystalline D-amino acid oxidase. II. Isolation of a reduced 14C-labeled substrate-enzyme intermediate after the action of sodium borohydride.
The Journal of biological chemistry. 240(10):4058-64 [PMID] 4378859.
1962
Specificity of the D-amino acid oxidase in relation to glycine oxidase activity.
The Journal of biological chemistry. 237:PC976-PC978 [PMID] 14478855.

Contact Details

Phones:
Business:
(352) 392-0687
Emails:
Business:
ahneims@ufl.edu
Addresses:
Business Mailing:
PO Box 100267
GAINESVILLE FL 32610
Business Street:
R5204 ARB
GAINESVILLE FL 32611