Emily K Moser,
Assistant Professor
Department:
MD-PULMONARY MEDICINE
Business Phone:
(352) 273-9953
Business Email:
emily.moser@medicine.ufl.edu
Teaching Profile
Courses Taught
2020-2022
GMS6337 B Cell Development in Health and Disease
2021-2025
GMS5905 Special Topics in Biomedical Sciences
2023-2025
GMS6140 Principles of Immunology
Publications
Academic Articles
2025
Targeting Lineage-Specific Functions of NR4A1 for Cancer Immunotherapy
International Journal of Molecular Sciences.
26(11)
[DOI] 10.3390/ijms26115266.
2024
PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy
Journal of Experimental Medicine.
221(3)
[DOI] 10.1084/jem.20231519.
[PMID] 38334978.
2023
B cell expression of E3 ubiquitin ligase Cul4b promotes chronic gammaherpesvirus infection in vivo
Journal of Virology.
97(12)
[DOI] 10.1128/jvi.01008-23.
[PMID] 37962378.
2023
The Ubiquitin Ligase Itch Skews Light Zone Selection in Germinal Centers
The Journal of Immunology.
210(10):1473-1481
[DOI] 10.4049/jimmunol.2200824.
[PMID] 36929899.
2023
Unleashing the Power of NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.08.09.552650.
[PMID] 37609171.
2022
Gammaherpesvirus-mediated repression reveals EWSR1 to be a negative regulator of B cell responses
Proceedings of the National Academy of Sciences.
119(32)
[DOI] 10.1073/pnas.2123362119.
[PMID] 35921433.
2022
Metabolic regulation of follicular helper T cell differentiation in a mouse model of lupus
Immunology Letters.
247:13-21
[DOI] 10.1016/j.imlet.2022.03.008.
2022
The ubiquitin ligase Cul5 regulates CD4+ T cell fate choice and allergic inflammation.
Nature communications.
13(1)
[DOI] 10.1038/s41467-022-30437-x.
[PMID] 35589717.
2021
Immune Dysregulation in Human ITCH Deficiency Successfully Treated with Hematopoietic Cell Transplantation.
The journal of allergy and clinical immunology. In practice.
9(7):2885-2893.e3
[DOI] 10.1016/j.jaip.2021.04.010.
[PMID] 33894394.
2020
Itch attenuates CD4 T-cell proliferation in mice by limiting WBP2 protein stability.
European journal of immunology.
50(10):1468-1483
[DOI] 10.1002/eji.201948323.
[PMID] 32459862.
2020
Itch regulation of innate and adaptive immune responses in mice and humans.
Journal of leukocyte biology.
108(1):353-362
[DOI] 10.1002/JLB.3MIR0320-272R.
[PMID] 32356405.
2020
Targeting the ion channel TRPM7 promotes the thymic development of regulatory T cells by promoting IL-2 signaling.
Science signaling.
13(661)
[DOI] 10.1126/scisignal.abb0619.
[PMID] 33293462.
2019
Regulation of autoimmune disease by the E3 ubiquitin ligase Itch.
Cellular immunology.
340
[DOI] 10.1016/j.cellimm.2019.04.004.
[PMID] 31126634.
2019
Special Issue: E3 ubiquitin ligases, the match makers and grim reapers of immune cells.
Cellular immunology.
340
[DOI] 10.1016/j.cellimm.2019.103924.
[PMID] 31101325.
2019
The E3 ubiquitin ligase Itch restricts antigen-driven B cell responses.
The Journal of experimental medicine.
216(9):2170-2183
[DOI] 10.1084/jem.20181953.
[PMID] 31311822.
2018
Aberrant Th2 inflammation drives dysfunction of alveolar macrophages and susceptibility to bacterial pneumonia.
Cellular & molecular immunology.
15(5):480-492
[DOI] 10.1038/cmi.2016.69.
[PMID] 28260794.
2017
Influenza A induces dysfunctional immunity and death in MeCP2-overexpressing mice.
JCI insight.
2(2)
[DOI] 10.1172/jci.insight.88257.
[PMID] 28138553.
2017
Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease.
Nature communications.
8
[DOI] 10.1038/ncomms15677.
[PMID] 28580955.
2015
Control of pathogenic effector T-cell activities in situ by PD-L1 expression on respiratory inflammatory dendritic cells during respiratory syncytial virus infection.
Mucosal immunology.
8(4):746-59
[DOI] 10.1038/mi.2014.106.
[PMID] 25465101.
2015
IL-21R signaling suppresses IL-17+ gamma delta T cell responses and production of IL-17 related cytokines in the lung at steady state and after Influenza A virus infection.
PloS one.
10(4)
[DOI] 10.1371/journal.pone.0120169.
[PMID] 25849970.
2014
Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner.
PLoS pathogens.
10(8)
[DOI] 10.1371/journal.ppat.1004315.
[PMID] 25144228.
2012
Dendritic cells tolerized with adenosine A₂AR agonist attenuate acute kidney injury.
The Journal of clinical investigation.
122(11):3931-42
[DOI] 10.1172/JCI63170.
[PMID] 23093781.
2011
CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs.
Nature immunology.
12(4):327-34
[DOI] 10.1038/ni.1996.
[PMID] 21297642.
Grants
Jul 2025
ACTIVE
Alpha-1 Antitrypsin Promotes Vaccine Antibody Responses
Role: Principal Investigator
Funding: ALPHA ONE FOU
Jul 2025
ACTIVE
The ubiquitin ligase Itch limits mTORC1 nutrient sensing in B cells
Role: Principal Investigator
Funding: NATL INST OF HLTH NCATS
Oct 2024
ACTIVE
S1P transport inhibitors for T1D Prophylaxis
Role: Principal Investigator
Funding: UNIV OF VIRGINIA
via BREAKTHROUGH T1D – formerly JDRF Intl
Aug 2024
ACTIVE
Metabolic enforcement of selection in anti-DNA B cells vs. antigen-specific B cells
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2024
ACTIVE
Alpha-1 Antitrypsin Promotes Vaccine Antibody Responses
Role: Principal Investigator
Funding: ALPHA ONE FOU
Apr 2024
ACTIVE
Proteolysis targeting chimera against nuclear receptor NR4A1 for melanoma therapy
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Jul 2022
– Jun 2024
Improving germinal center responses to influenza A virus vaccination through a novel ubiquitin ligase pathway
Role: Principal Investigator
Funding: AMER LUNG ASSO
Jan 2021
– Dec 2022
Itch Ubiquitin Ligase and Germinal Center B cells
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Contact Details
Phones:
- Business:
- (352) 273-9953
Emails:
- Business:
- emily.moser@medicine.ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100267
GAINESVILLE FL 32610 - Business Street:
-
MSB M440
1345 Center Dr.
Gainesville FL 32610