Edwin M Meyer

Edwin M Meyer, Ph.D.

Emeritus Associate Professor

Department: MD-PHARMACOLOGY / THERAPEUTICS
Business Phone: (352) 392-6364
Business Email: meyere@ufl.edu

Teaching Profile

Courses Taught
2008
DEN6262 Prin of Pharmacology
2006
GMS7593 Topics in Pharmacology and Toxicology
2006
PHA4904 Pharmacology Research

Publications

2009
Effects of Alpha 7 Nicotinic Receptor Gene Delivery On Processes Underlying Cell Viability
Molecular Therapy. 17
2008
Modulation of spontaneous hippocampal synaptic events with 5-hydroxyindole, 4OH-GTS-21, and rAAV-mediated alpha7 nicotinic receptor gene transfer.
Brain research. 1203:51-60 [DOI] 10.1016/j.brainres.2008.02.011. [PMID] 18321476.
2007
alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation.
Neuroscience. 145(1):314-22 [PMID] 17218065.
2007
Brain-derived neurotrophic factor prevents human immunodeficiency virus type 1 protein gp120 neurotoxicity in the rat nigrostriatal system.
Annals of the New York Academy of Sciences. 1122:144-54 [PMID] 18077570.
2007
Brain-derived neurotrophic factor prevents the nigrostriatal degeneration induced by human immunodeficiency virus-1 glycoprotein 120 in vivo.
The European journal of neuroscience. 25(8):2275-84 [PMID] 17445226.
2007
Peripheral transgene expression of plasma gelsolin reduces amyloid in transgenic mouse models of Alzheimer’s disease.
Molecular therapy : the journal of the American Society of Gene Therapy. 15(9):1623-9 [PMID] 17609655.
2007
The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.
Neuroscience. 148(1):230-7 [PMID] 17640819.
2006
Memory-related deficits following selective hippocampal expression of Swedish mutation amyloid precursor protein in the rat.
Experimental neurology. 200(2):371-7 [PMID] 16780838.
2005
AAV2/5-mediated NGF gene delivery protects septal cholinergic neurons following axotomy.
Brain research. 1061(2):107-13 [PMID] 16226726.
2005
An alpha7 nicotinic acetylcholine receptor gain-of-function mutant that retains pharmacological fidelity.
Molecular pharmacology. 68(6):1863-76 [PMID] 16186249.
2005
Medial septal/diagonal band cells express multiple functional nicotinic receptor subtypes that are correlated with firing frequency.
Neuroscience letters. 389(3):163-8 [PMID] 16112453.
2005
Multiple calcium channels and kinases mediate alpha7 nicotinic receptor neuroprotection in PC12 cells.
Journal of neurochemistry. 94(4):926-33 [PMID] 15969741.
2005
Septal innervation regulates the function of alpha7 nicotinic receptors in CA1 hippocampal interneurons.
Experimental neurology. 195(2):342-52 [PMID] 16000197.
2004
A single point mutation confers properties of the muscle-type nicotinic acetylcholine receptor to homomeric alpha7 receptors.
Molecular pharmacology. 66(1):169-77 [PMID] 15213309.
2004
Effects at a distance in alpha 7 nAChR selective agonists: benzylidene substitutions that regulate potency and efficacy.
Neuropharmacology. 46(7):1023-38 [PMID] 15081799.
2004
Polyethylenimine-mediated NGF gene delivery protects transected septal cholinergic neurons.
Brain research. 1008(2):284-7 [PMID] 15145767.
2004
Presynaptic dopaminergic properties of differentiated mouse embryonic stem cells.
Neurochemistry international. 45(7):1067-73 [PMID] 15337306.
2004
Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.
The American journal of pathology. 164(1):347-53 [PMID] 14695347.
2004
Recombinant adeno-associated virus serotype 2 effectively transduces primary rat brain astrocytes and microglia.
Brain research. Brain research protocols. 14(1):18-24 [PMID] 15519948.
2004
The effects of rAAV2-mediated NGF gene delivery in adult and aged rats.
Molecular therapy : the journal of the American Society of Gene Therapy. 9(2):262-9 [PMID] 14759810.
2003
Adeno-associated virus vector expressing nerve growth factor enhances cholinergic axonal sprouting after cortical injury in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(7):2797-803 [PMID] 12684466.
2003
Long-term neuronal effects and disposition of ectopic preproNGF gene transfer into the rat septum.
Human gene therapy. 14(15):1463-72 [PMID] 14577926.
2003
Regulation of neuronal function by choline and 4OH-GTS-21 through alpha 7 nicotinic receptors.
Journal of neurophysiology. 89(4):1797-806 [PMID] 12611953.
2002
A role for protein kinase C and its substrates in the action of valproic acid in the brain: implications for neural plasticity.
Brain research. 934(1):69-80 [PMID] 11937071.
2002
Activation and inhibition of native neuronal alpha-bungarotoxin-sensitive nicotinic ACh receptors.
Brain research. 948(1-2):33-46 [PMID] 12383953.
2002
Alpha7 nicotinic receptor activation inhibits ethanol-induced mitochondrial dysfunction, cytochrome c release and neurotoxicity in primary rat hippocampal neuronal cultures.
Journal of neurochemistry. 81(4):853-8 [PMID] 12065644.
2002
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.
Nature. 416(6880):542-5 [PMID] 11932747.
2002
CD9 is associated with leukemia inhibitory factor-mediated maintenance of embryonic stem cells.
Molecular biology of the cell. 13(4):1274-81 [PMID] 11950938.
2002
Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra.
Human gene therapy. 13(5):605-12 [PMID] 11916484.
2002
Dose and promoter effects of adeno-associated viral vector for green fluorescent protein expression in the rat brain.
Experimental neurology. 176(1):66-74 [PMID] 12093083.
2002
Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats.
Neuroscience. 115(3):879-89 [PMID] 12435426.
2002
Measurements of vector-derived neurotrophic factor and green fluorescent protein levels in the brain.
Methods (San Diego, Calif.). 28(2):286-92 [PMID] 12413428.
2002
Particle detection, number estimation, and feature measurement in gene transfer studies: optical fractionator stereology integrated with digital image processing and analysis.
Methods (San Diego, Calif.). 28(2):293-9 [PMID] 12413429.
2002
Plasmid delivery in the rat brain.
Bioscience reports. 22(2):297-308 [PMID] 12428906.
2001
Transgene delivery with a cationic lipid in the presence of amyloid beta (betaAP) peptide.
Neurochemical research. 26(3):195-202 [PMID] 11495542.
2000
Adeno-associated virus mediated gene transfer into primary rat brain neuronal and glial cultures: enhancement with the pH-sensitive surfactant dodecyl 2-(1′-imidazolyl) propionate.
Neurochemistry international. 37(1):1-6 [PMID] 10781840.
2000
alpha7 nicotinic receptor-mediated protection against ethanol-induced oxidative stress and cytotoxicity in PC12 cells.
Brain research. 861(1):165-7 [PMID] 10751577.
2000
alpha7 receptor-selective agonists and modes of alpha7 receptor activation.
European journal of pharmacology. 393(1-3):179-95 [PMID] 10771012.
1999
Alpha7 nicotinic receptor mediated protection against ethanol-induced cytotoxicity in PC12 cells.
Brain research. 816(1):225-8 [PMID] 9878750.
1999
Characterization of the neuroprotective and toxic effects of alpha7 nicotinic receptor activation in PC12 cells.
Brain research. 830(2):218-25 [PMID] 10366678.
1999
Enhanced transgene expression in rat brain cell cultures with a disulfide-containing cationic lipid.
Neuroscience letters. 277(3):141-4 [PMID] 10626833.
1999
Generation of aberrant sprouting in the adult rat brain by GAP-43 somatic gene transfer.
Brain research. 832(1-2):136-44 [PMID] 10375659.
1999
Long-term actions of vector-derived nerve growth factor or brain-derived neurotrophic factor on choline acetyltransferase and Trk receptor levels in the adult rat basal forebrain.
Neuroscience. 90(3):815-21 [PMID] 10218782.
1999
Pre-exposure of cells to cationic lipids enhances transgene delivery and expression in a tissue culture cell line.
Journal of drug targeting. 7(3):207-11 [PMID] 10680976.
1999
Prevention of 6-hydroxydopamine-induced rotational behavior by BDNF somatic gene transfer.
Brain research. 847(2):314-20 [PMID] 10575102.
1998
Analysis of 3-(4-hydroxy, 2-Methoxybenzylidene)anabaseine selectivity and activity at human and rat alpha-7 nicotinic receptors.
The Journal of pharmacology and experimental therapeutics. 287(3):918-25 [PMID] 9864273.
1998
Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors.
Experimental neurology. 150(2):183-94 [PMID] 9527887.
1998
Neuroprotective and memory-related actions of novel alpha-7 nicotinic agents with different mixed agonist/antagonist properties.
The Journal of pharmacology and experimental therapeutics. 284(3):1026-32 [PMID] 9495863.
1998
NGF gene expression in dividing and non-dividing cells from AAV-derived constructs.
Neurochemical research. 23(5):779-86 [PMID] 9566618.
1998
Reduced MK801 binding in neocortical neurons after AAV-mediated transfections with NMDA-R1 antisense cDNA.
Brain research. 784(1-2):325-8 [PMID] 9518673.
1997
17 beta-estradiol attenuates fimbrial lesion-induced decline of ChAT-immunoreactive neurons in the rat medial septum.
Experimental neurology. 146(1):179-86 [PMID] 9225751.
1997
3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner.
Brain research. 768(1-2):49-56 [PMID] 9369300.
1997
Activation and inhibition of rat neuronal nicotinic receptors by ABT-418.
British journal of pharmacology. 120(3):429-38 [PMID] 9031746.
1996
An AAV promoter-driven neuropeptide Y gene delivery system using Sendai virosomes for neurons and rat brain.
Gene therapy. 3(3):246-53 [PMID] 8646556.
1995
Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal nicotinic alpha 7/125I-alpha-bungarotoxin receptor subtypes.
Molecular pharmacology. 47(1):164-71 [PMID] 7838125.
1995
Sendai virosomal infusion of an adeno-associated virus-derived construct containing neuropeptide Y into primary rat brain cultures.
Neuroscience letters. 190(2):73-6 [PMID] 7543991.
1995
The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats.
Endocrinology. 136(5):2320-4 [PMID] 7720680.
1994
A novel nicotinic agonist facilitates induction of long-term potentiation in the rat hippocampus.
Neuroscience letters. 168(1-2):130-4 [PMID] 8028765.
1994
Chronic ethanol alters CNS cholinergic and cerebellar development in chick embryos.
Alcohol (Fayetteville, N.Y.). 11(3):187-94 [PMID] 8060518.
1994
Differential adenoassociated virus vector-driven expression of a neuropeptide Y gene in primary rat brain astroglial cultures after transfection with Sendai virosomes versus Lipofectin.
Neurochemical research. 19(6):643-8 [PMID] 8065520.
1994
Differential neuropeptide Y gene expression in post-mitotic versus dividing neuroblastoma cells driven by an adeno-associated virus vector.
Brain research. Molecular brain research. 24(1-4):27-33 [PMID] 7968366.
1994
Effects of peroxidation and aging on rat neocortical ACh-release and protein kinase C.
Neurobiology of aging. 15(1):63-7 [PMID] 8159264.
1994
Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats.
Brain research. 644(2):305-12 [PMID] 8050041.
1993
Actions of a monoclonal antibody Tor 23 on rat brain presynaptic cholinergic processes.
Neurochemical research. 18(3):339-44 [PMID] 8479603.
1993
Characterization of [3H]vesamicol binding in rat brain preparations.
Neurochemical research. 18(10):1067-72 [PMID] 8255355.
1993
Effects of membrane peroxidation on [3H]acetylcholine release in rat cerebral cortical synaptosomes.
Neurochemical research. 18(10):1047-50 [PMID] 8255353.
1993
Fusogenic properties of Sendai virosome envelopes in rat brain preparations.
Neurochemical research. 18(10):1089-94 [PMID] 8255357.
1993
Recovery of [3H]acetylcholine synthesis after AF64A-treatment in primary, neuron-enriched, rat septal-hippocampal and striatal cultures.
Brain research. Developmental brain research. 74(1):51-6 [PMID] 8403375.
1993
The development of age-related deficits in several presynaptic processes associated with brain [3H]acetylcholine release.
Mechanisms of ageing and development. 72(2):119-28 [PMID] 8152316.
1992
Synthesis and release of acetylcholine in the rabbit kidney cortex.
Life sciences. 51(22):1699-703 [PMID] 1435079.
1990
Effects of benzoyltropine and tropacocaine on several cholinergic processes in the rat brain.
The Journal of pharmacology and experimental therapeutics. 254(2):584-90 [PMID] 1974643.
1990
Effects of nucleus basalis lesions on cerebral cortical concentrations of corticotropin-releasing hormone (CRH)-like immunoreactivity in the rat.
Neuroscience letters. 113(2):233-9 [PMID] 2377321.
1990
Neuropeptide Y-cholinergic interactions in neocortical tissue.
Annals of the New York Academy of Sciences. 611:219-25 [PMID] 2248476.
1989
Cholinergic properties of rat atrial subcellular preparations.
Journal of molecular and cellular cardiology. 21(3):305-13 [PMID] 2746656.
1989
Differential effects of 4-aminopyridine on acetylcholine release triggered by K+ depolarization, veratridine, or A23187 in rat cerebral cortical synaptosomes.
Neurochemical research. 14(2):157-60 [PMID] 2542820.
1989
Dipalmitoylphosphatidylcholine liposomes reduce [3H]acetylcholine levels in an eserine-sensitive manner in rat cerebral cortical synaptosomes.
Neurochemical research. 14(2):161-7 [PMID] 2725816.
1988
Pharmacological characterization of high affinity choline transporters in primary neuronal cultures in rat brain.
Neuropharmacology. 27(8):837-42 [PMID] 3216963.
1987
Effects of nucleus basalis lesions on the muscarinic and nicotinic modulation of [3H]acetylcholine release in the rat cerebral cortex.
Journal of neurochemistry. 49(6):1758-62 [PMID] 3681294.
1987
Studies on putative neurotransmitters in an animal model of hereditary blindness.
Progress in clinical and biological research. 247:407-22 [PMID] 2891143.
1987
Ubiquitin-directed antibodies inhibit neuronal transporters in rat brain synaptosomes.
Journal of neurochemistry. 49(6):1815-9 [PMID] 2890715.
1986
Effects of different secretagogues and intracellular messengers on the muscarinic modulation of [3H]acetylcholine release.
Neurochemical research. 11(11):1547-56 [PMID] 3120025.

Contact Details

Phones:
Business:
(352) 392-6364
Emails:
Business:
meyere@ufl.edu
Addresses:
Business Mailing:
PO Box 100267
GAINESVILLE FL 32610
Business Street:
R5110 ARB
GAINESVILLE FL 32611