Rajesh Khanna

Rajesh Khanna,

Richard And Thelma O.C. Barney Term Professor And Director, Pain And Addiction Therapeutics (PATH) Collaboratory

Department: MD-PHARMACOLOGY / THERAPEUTICS
Business Phone: (520) 271-0433
Business Email: r.khanna@ufl.edu

About Rajesh Khanna

Additional Positions:
Director, Pain and Addiction Therapeutics (PATH) Collaboratory
2024 – Current · University of Florida

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9066-2969

Publications

2024
A parabrachial hub for the prioritization of survival behavior.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2024.02.26.582069. [PMID] 38464066.
2024
C-H Functionalization-Enabled 11-Step Semisynthesis of (-)-Veragranine A and Characterization of Synthetic Analogs in Osteoarthritis-related Pain Treatment.
Journal of the American Chemical Society. 146(24):16698-705 [DOI] 10.1021/jacs.4c04025. [PMID] 38843262.
2024
Human Hsp70 Substrate-Binding Domains Recognize Distinct Client Proteins.
Biochemistry. 63(3):251-263 [DOI] 10.1021/acs.biochem.3c00531. [PMID] 38243804.
2024
Intranasal CRMP2-Ubc9 inhibitor regulates Na V 1.7 to alleviate trigeminal neuropathic pain.
Pain. 165(3):573-588 [DOI] 10.1097/j.pain.0000000000003053. [PMID] 37751532.
2024
Mechanism, and treatment of anti-CV2/CRMP5 autoimmune pain.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2024.05.04.592533. [PMID] 38766071.
2024
Mouse models of non-dystrophic and dystrophic myotonia exhibit nociplastic pain-like behaviors.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2024.06.19.599732. [PMID] 38948724.
2024
Neuropilin-1 is a co-receptor for NGF and TrkA-evoked pain.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.12.06.570398. [PMID] 38106002.
2024
NF1+/ex42del miniswine model the cellular disruptions and behavioral presentations of NF1-associated cognitive and motor impairment.
Clinical and translational science. 17(6) [DOI] 10.1111/cts.13858. [PMID] 38932491.
2024
Nociplastic pain mechanisms and toll-like receptors as promising targets for its management.
Pain. [DOI] 10.1097/j.pain.0000000000003238. [PMID] 38595206.
2024
Regulating neuronal excitability: The role of S-palmitoylation in NaV1.7 activity and voltage sensitivity.
PNAS nexus. 3(6) [DOI] 10.1093/pnasnexus/pgae222. [PMID] 38894876.
2024
STINGing away the pain: the role of interferon-stimulated genes.
The Journal of clinical investigation. 134(9) [DOI] 10.1172/JCI180497. [PMID] 38690736.
2024
Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain.
Pain. 165(4):866-883 [DOI] 10.1097/j.pain.0000000000003080. [PMID] 37862053.
2024
Uncoupling the CRMP2-CaV2.2 interaction reduces pain-like behavior in a preclinical osteoarthritis model.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2024.06.05.596514. [PMID] 38895294.
2023
A new polymodal gating model of the proton-activated chloride channel.
PLoS biology. 21(9) [DOI] 10.1371/journal.pbio.3002309. [PMID] 37713449.
2023
A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain.
Proceedings of the National Academy of Sciences of the United States of America. 120(47) [DOI] 10.1073/pnas.2305215120. [PMID] 37972067.
2023
Argentatin C Analogues with Potential Antinociceptive Activity and Other Triterpenoid Constituents from the Aerial Parts of Parthenium incanum.
ACS omega. 8(22):20085-20095 [DOI] 10.1021/acsomega.3c02302. [PMID] 37305315.
2023
Betulinic acid analogs inhibit N- and T-type voltage-gated calcium channels to attenuate nerve-injury associated neuropathic and formalin models of pain.
Neurobiology of pain (Cambridge, Mass.). 13 [DOI] 10.1016/j.ynpai.2023.100116. [PMID] 36687466.
2023
Chronic pain recruits hypothalamic dynorphin/kappa opioid receptor signalling to promote wakefulness and vigilance.
Brain : a journal of neurology. 146(3):1186-1199 [DOI] 10.1093/brain/awac153. [PMID] 35485490.
2023
Glutamatergic and GABAergic neurons in the vLGN mediate the nociceptive effects of green and red light on neuropathic pain.
Neurobiology of disease. 183 [DOI] 10.1016/j.nbd.2023.106164. [PMID] 37217103.
2023
Identification and targeting of a unique NaV1.7 domain driving chronic pain.
Proceedings of the National Academy of Sciences of the United States of America. 120(32) [DOI] 10.1073/pnas.2217800120. [PMID] 37498871.
2023
Intranasal CRMP2-Ubc9 Inhibitor Regulates Na V 1.7 to Alleviate Trigeminal Neuropathic Pain.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.07.16.549195. [PMID] 37502910.
2023
Neuropilin-1 is essential for vascular endothelial growth factor A-mediated increase of sensory neuron activity and development of pain-like behaviors.
Pain. 164(12):2696-2710 [DOI] 10.1097/j.pain.0000000000002970. [PMID] 37366599.
2023
Some Like It Hot: Dynamic Control of Cav2.2 Channels By Chili Peppers.
Function (Oxford, England). 4(1) [DOI] 10.1093/function/zqac066. [PMID] 36632472.
2023
Targeting the vascular endothelial growth factor A/neuropilin 1 axis for relief of neuropathic pain.
Pain. 164(7):1473-1488 [DOI] 10.1097/j.pain.0000000000002850. [PMID] 36729125.
2023
The Ca2+ channel ORAI1 is a regulator of oral cancer growth and nociceptive pain.
Science signaling. 16(801) [DOI] 10.1126/scisignal.adf9535. [PMID] 37669398.
2023
The Emerging Translational Potential of MNK Inhibitors for the Treatment of Chronic Pain.
Neuroscience. 515:93-95 [DOI] 10.1016/j.neuroscience.2023.02.009. [PMID] 36922084.
2023
The natural product argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels.
British journal of pharmacology. 180(9):1267-1285 [DOI] 10.1111/bph.15974. [PMID] 36245395.
2022
A prolactin-dependent sexually dimorphic mechanism of migraine chronification.
Cephalalgia : an international journal of headache. 42(3):197-208 [DOI] 10.1177/03331024211039813. [PMID] 34510920.
2022
Alternaria alternata-induced airway epithelial signaling and inflammatory responses via protease-activated receptor-2 expression.
Biochemical and biophysical research communications. 591:13-19 [DOI] 10.1016/j.bbrc.2021.12.090. [PMID] 34990903.
2022
Ca V 3.2 calcium channels: new players in facial pain.
Pain. 163(12):e1166-e1168 [DOI] 10.1097/j.pain.0000000000002652. [PMID] 35442930.
2022
Cell specific regulation of NaV1.7 activity and trafficking in rat nodose ganglia neurons.
Neurobiology of pain (Cambridge, Mass.). 12 [DOI] 10.1016/j.ynpai.2022.100109. [PMID] 36531612.
2022
Conditional knockout of CRMP2 in neurons, but not astrocytes, disrupts spinal nociceptive neurotransmission to control the initiation and maintenance of chronic neuropathic pain.
Pain. 163(2):e368-e381 [DOI] 10.1097/j.pain.0000000000002344. [PMID] 35029600.
2022
Conotoxin contulakin-G engages a neurotensin receptor 2/R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception.
Pain. 163(9):1751-1762 [DOI] 10.1097/j.pain.0000000000002561. [PMID] 35050960.
2022
Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine.
Brain : a journal of neurology. 145(8):2894-2909 [DOI] 10.1093/brain/awac104. [PMID] 35325034.
2022
Effect of morphine and ibuprofen on nociceptive behavior, preening and motor activity following tonic chemical pain in the Japanese quail (Coturnix japonica).
Veterinary anaesthesia and analgesia. 49(5):499-509 [DOI] 10.1016/j.vaa.2022.07.001. [PMID] 35961922.
2022
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.
Scientific reports. 12(1) [DOI] 10.1038/s41598-022-12191-8. [PMID] 35581326.
2022
Neurodegenerative Diseases: From Dysproteostasis, Altered Calcium Signalosome to Selective Neuronal Vulnerability to AAV-Mediated Gene Therapy.
International journal of molecular sciences. 23(22) [DOI] 10.3390/ijms232214188. [PMID] 36430666.
2022
Neuronal allodynic mechanisms of Slc7a5 (LAT1) in the spared nerve injury rodent model of neuropathic pain.
Pflugers Archiv : European journal of physiology. 474(4):397-403 [DOI] 10.1007/s00424-021-02653-9. [PMID] 35048187.
2022
Neuronal CRMP2 phosphorylation inhibition by the flavonoid, naringenin, contributes to the reversal of spinal sensitization and arthritic pain improvement.
Arthritis research & therapy. 24(1) [DOI] 10.1186/s13075-022-02975-8. [PMID] 36564853.
2022
Plant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels.
Channels (Austin, Tex.). 16(1):198-215 [DOI] 10.1080/19336950.2022.2103234. [PMID] 36017978.
2022
Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin-induced neuropathic pain.
Neurobiology of pain (Cambridge, Mass.). 11 [DOI] 10.1016/j.ynpai.2021.100082. [PMID] 35024498.
2022
Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats.
Channels (Austin, Tex.). 16(1):1-8 [DOI] 10.1080/19336950.2021.2023383. [PMID] 34983286.
2022
Stereospecific Effects of Benzimidazolonepiperidine Compounds on T-Type Ca2+ Channels and Pain.
ACS chemical neuroscience. 13(13):2035-2047 [DOI] 10.1021/acschemneuro.2c00256. [PMID] 35671441.
2022
The small molecule compound C65780 alleviates pain by stabilizing voltage-gated sodium channels in the inactivated and slowly-recovering state.
Neuropharmacology. 212 [DOI] 10.1016/j.neuropharm.2022.109057. [PMID] 35413303.
2022
Transmembrane protein TMEM184B is necessary for interleukin-31-induced itch.
Pain. 163(5):e642-e653 [DOI] 10.1097/j.pain.0000000000002452. [PMID] 34629389.
2021
Comparison of quinazoline and benzoylpyrazoline chemotypes targeting the CaVα-β interaction as antagonists of the N-type CaV2.2 channel.
Channels (Austin, Tex.). 15(1):128-135 [DOI] 10.1080/19336950.2020.1863595. [PMID] 33416017.
2021
Evaluation of green light exposure on headache frequency and quality of life in migraine patients: A preliminary one-way cross-over clinical trial.
Cephalalgia : an international journal of headache. 41(2):135-147 [DOI] 10.1177/0333102420956711. [PMID] 32903062.
2021
Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency.
Neurobiology of disease. 149 [DOI] 10.1016/j.nbd.2020.105224. [PMID] 33359140.
2021
Green Light Antinociceptive and Reversal of Thermal and Mechanical Hypersensitivity Effects Rely on Endogenous Opioid System Stimulation.
The journal of pain. 22(12):1646-1656 [DOI] 10.1016/j.jpain.2021.05.006. [PMID] 34157406.
2021
Green Light Exposure Improves Pain and Quality of Life in Fibromyalgia Patients: A Preliminary One-Way Crossover Clinical Trial.
Pain medicine (Malden, Mass.). 22(1):118-130 [DOI] 10.1093/pm/pnaa329. [PMID] 33155057.
2021
Intellectual disability: dendritic anomalies and emerging genetic perspectives.
Acta neuropathologica. 141(2):139-158 [DOI] 10.1007/s00401-020-02244-5. [PMID] 33226471.
2021
L5-6 Spinal Nerve Ligation-induced Neuropathy Changes the Location and Function of Ca2+ Channels and Cdk5 and Affects the Compound Action Potential in Adjacent Intact L4 Afferent Fibers.
Neuroscience. 471:20-31 [DOI] 10.1016/j.neuroscience.2021.07.013. [PMID] 34303780.
2021
Missense variants in DPYSL5 cause a neurodevelopmental disorder with corpus callosum agenesis and cerebellar abnormalities.
American journal of human genetics. 108(5):951-961 [DOI] 10.1016/j.ajhg.2021.04.004. [PMID] 33894126.
2021
Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15.
Molecular brain. 14(1) [DOI] 10.1186/s13041-020-00714-1. [PMID] 33478555.
2021
Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry.
ACS chemical neuroscience. 12(8):1299-1312 [DOI] 10.1021/acschemneuro.0c00619. [PMID] 33787218.
2021
SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia.
Pain. 162(1):243-252 [DOI] 10.1097/j.pain.0000000000002097. [PMID] 33009246.
2021
Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents.
Science translational medicine. 13(619) [DOI] 10.1126/scitranslmed.abh1314. [PMID] 34757807.
2021
Targeting T-type/CaV3.2 channels for chronic pain.
Translational research : the journal of laboratory and clinical medicine. 234:20-30 [DOI] 10.1016/j.trsl.2021.01.002. [PMID] 33422652.
2021
The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area.
Frontiers in pharmacology. 12 [DOI] 10.3389/fphar.2021.632757. [PMID] 33953672.
2020
1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain.
Molecular brain. 13(1) [DOI] 10.1186/s13041-020-00616-2. [PMID] 32393368.
2020
A modulator of the low-voltage-activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies.
Pain. 161(11):2551-2570 [DOI] 10.1097/j.pain.0000000000001955. [PMID] 32541387.
2020
Collapsin Response Mediator Proteins: Novel Targets for Alzheimer’s Disease.
Journal of Alzheimer's disease : JAD. 77(3):949-960 [DOI] 10.3233/JAD-200721. [PMID] 32804096.
2020
Coordinating Synaptic Signaling with CRMP2.
The international journal of biochemistry & cell biology. 124 [DOI] 10.1016/j.biocel.2020.105759. [PMID] 32437854.
2020
Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury.
Molecular brain. 13(1) [DOI] 10.1186/s13041-020-00633-1. [PMID] 32571373.
2020
Druggability of CRMP2 for Neurodegenerative Diseases.
ACS chemical neuroscience. 11(17):2492-2505 [DOI] 10.1021/acschemneuro.0c00307. [PMID] 32693579.
2020
Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking.
Molecular neurobiology. 57(1):346-357 [DOI] 10.1007/s12035-019-01711-9. [PMID] 31359322.
2020
In silico identification and validation of inhibitors of the interaction between neuropilin receptor 1 and SARS-CoV-2 Spike protein.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2020.09.22.308783. [PMID] 32995772.
2020
Just in time! Identification of a novel mechanism for treating PIPN.
The Journal of physiology. 598(12):2283-2284 [DOI] 10.1113/JP279863. [PMID] 32266977.
2020
Longitudinal phenotype development in a minipig model of neurofibromatosis type 1.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-61251-4. [PMID] 32193437.
2020
Nasal delivery of a CRMP2-derived CBD3 adenovirus improves cognitive function and pathology in APP/PS1 transgenic mice.
Molecular brain. 13(1) [DOI] 10.1186/s13041-020-00596-3. [PMID] 32272942.
2020
Putative roles of SLC7A5 (LAT1) transporter in pain.
Neurobiology of pain (Cambridge, Mass.). 8 [DOI] 10.1016/j.ynpai.2020.100050. [PMID] 32715162.
2020
SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2020.07.17.209288. [PMID] 32869019.
2020
Sculpting Dendritic Spines during Initiation and Maintenance of Neuropathic Pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(40):7578-7589 [DOI] 10.1523/JNEUROSCI.1664-20.2020. [PMID] 32998955.
2020
Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific Nav1.7 regulation in the pathogenesis of chronic neuropathic pain.
Pain. 161(11):2629-2651 [DOI] 10.1097/j.pain.0000000000001951. [PMID] 32569093.
2020
Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1.
Science advances. 6(27) [DOI] 10.1126/sciadv.abb1515. [PMID] 32937457.
2020
Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels.
Science advances. 6(27) [DOI] 10.1126/sciadv.aaz8110. [PMID] 32937450.
2020
The investigation of the T-type calcium channel enhancer SAK3 in an animal model of TAF1 intellectual disability syndrome.
Neurobiology of disease. 143 [DOI] 10.1016/j.nbd.2020.105006. [PMID] 32622085.
2020
The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females.
Science translational medicine. 12(529) [DOI] 10.1126/scitranslmed.aay7550. [PMID] 32024801.
2020
The role of cyclin-dependent kinase 5 in neuropathic pain.
Pain. 161(12):2674-2689 [DOI] 10.1097/j.pain.0000000000002027. [PMID] 32773603.
2020
Validating indicators of CNS disorders in a swine model of neurological disease.
PloS one. 15(2) [DOI] 10.1371/journal.pone.0228222. [PMID] 32074109.
2019
(-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels.
ACS chemical neuroscience. 10(3):1716-1728 [DOI] 10.1021/acschemneuro.8b00617. [PMID] 30525440.
2019
AAV-encoded CaV2.2 peptide aptamer CBD3A6K for primary sensory neuron-targeted treatment of established neuropathic pain.
Gene therapy. 26(7-8):308-323 [DOI] 10.1038/s41434-019-0082-7. [PMID] 31118475.
2019
Activity of T-type calcium channels is independent of CRMP2 in sensory neurons.
Channels (Austin, Tex.). 13(1):147-152 [DOI] 10.1080/19336950.2019.1608129. [PMID] 31025580.
2019
Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1.
Pain. 160(11):2473-2486 [DOI] 10.1097/j.pain.0000000000001648. [PMID] 31246731.
2019
Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels.
Pain. 160(1):117-135 [DOI] 10.1097/j.pain.0000000000001385. [PMID] 30169422.
2019
Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain.
Neurobiology of pain (Cambridge, Mass.). 5 [DOI] 10.1016/j.ynpai.2018.07.003. [PMID] 31080913.
2019
Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant.
Proceedings of the National Academy of Sciences of the United States of America. 116(31):15696-15705 [DOI] 10.1073/pnas.1903401116. [PMID] 31308225.
2019
Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light.
The journal of pain. 20(11):1293-1306 [DOI] 10.1016/j.jpain.2019.04.008. [PMID] 31054915.
2019
Discovery of Quinoline Analogues as Potent Antivirals against Enterovirus D68 (EV-D68).
Journal of medicinal chemistry. 62(8):4074-4090 [DOI] 10.1021/acs.jmedchem.9b00115. [PMID] 30912944.
2019
Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions.
Molecular neurobiology. 56(10):6736-6755 [DOI] 10.1007/s12035-019-1568-4. [PMID] 30915713.
2019
Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light’: The Journal of Pain 20 (2019) 1293-1306.
The journal of pain. 20(12) [DOI] 10.1016/j.jpain.2019.11.012. [PMID] 31818395.
2019
Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief.
Channels (Austin, Tex.). 13(1):498-504 [DOI] 10.1080/19336950.2019.1684608. [PMID] 31680630.
2019
Mining the Nav1.7 interactome: Opportunities for chronic pain therapeutics.
Biochemical pharmacology. 163:9-20 [DOI] 10.1016/j.bcp.2019.01.018. [PMID] 30699328.
2019
Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease.
Neuronal signaling. 3(2) [DOI] 10.1042/NS20190001. [PMID] 32269836.
2019
Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis.
ASN neuro. 11 [DOI] 10.1177/1759091419892090. [PMID] 31795726.
2019
Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission.
Molecular neurobiology. 56(7):5241-5255 [DOI] 10.1007/s12035-018-1445-6. [PMID] 30565051.
2019
Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Physalin F via Block of CaV2.3 (R-Type) and CaV2.2 (N-Type) Voltage-Gated Calcium Channels.
ACS chemical neuroscience. 10(6):2939-2955 [DOI] 10.1021/acschemneuro.9b00166. [PMID] 30946560.
2019
Small Molecule Targeting TDP-43’s RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS).
ACS chemical biology. 14(9):2006-2013 [DOI] 10.1021/acschembio.9b00481. [PMID] 31241884.
2019
TAF1-gene editing alters the morphology and function of the cerebellum and cerebral cortex.
Neurobiology of disease. 132 [DOI] 10.1016/j.nbd.2019.104539. [PMID] 31344492.
2019
Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.
Pain. 160(7):1644-1661 [DOI] 10.1097/j.pain.0000000000001524. [PMID] 30933958.
2019
Tetramethylpyrazine Reduces Epileptogenesis Progression in Electrical Kindling Models by Modulating Hippocampal Excitatory Neurotransmission.
ACS chemical neuroscience. 10(12):4854-4863 [DOI] 10.1021/acschemneuro.9b00575. [PMID] 31756074.
2019
The Natural Flavonoid Naringenin Elicits Analgesia through Inhibition of NaV1.8 Voltage-Gated Sodium Channels.
ACS chemical neuroscience. 10(12):4834-4846 [DOI] 10.1021/acschemneuro.9b00547. [PMID] 31697467.
2019
TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation.
Molecular brain. 12(1) [DOI] 10.1186/s13041-019-0538-0. [PMID] 31888677.
2019
Towards a neurobiological understanding of pain in neurofibromatosis type 1: mechanisms and implications for treatment.
Pain. 160(5):1007-1018 [DOI] 10.1097/j.pain.0000000000001486. [PMID] 31009417.
2018
A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).
ACS chemical biology. 13(10):3000-3010 [DOI] 10.1021/acschembio.8b00745. [PMID] 30141626.
2018
A light-gated potassium channel for sustained neuronal inhibition.
Nature methods. 15(11):969-976 [DOI] 10.1038/s41592-018-0186-9. [PMID] 30377377.
2018
A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome.
Neuronal signaling. 2(3) [DOI] 10.1042/NS20180141. [PMID] 32714589.
2018
A porcine model of neurofibromatosis type 1 that mimics the human disease.
JCI insight. 3(12) [DOI] 10.1172/jci.insight.120402. [PMID] 29925695.
2018
Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels.
Channels (Austin, Tex.). 12(1):219-227 [DOI] 10.1080/19336950.2018.1491244. [PMID] 30081699.
2018
CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain.
Neuronal signaling. 2(1) [DOI] 10.1042/NS20170220. [PMID] 30364788.
2018
CRMP2 is necessary for Neurofibromatosis type 1 related pain.
Channels (Austin, Tex.). 12(1):47-50 [DOI] 10.1080/19336950.2017.1370524. [PMID] 28837387.
2018
CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.
Molecular neurobiology. 55(5):4403-4416 [DOI] 10.1007/s12035-017-0653-9. [PMID] 28660485.
2018
CRMP2-Neurofibromin Interface Drives NF1-related Pain.
Neuroscience. 381:79-90 [DOI] 10.1016/j.neuroscience.2018.04.002. [PMID] 29655575.
2018
High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons.
eNeuro. 5(5) [DOI] 10.1523/ENEURO.0135-18.2018. [PMID] 30263951.
2018
Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.
British journal of pharmacology. 175(12):2244-2260 [DOI] 10.1111/bph.13737. [PMID] 28161890.
2018
In Reply.
Anesthesiology. 129(2):378-379 [DOI] 10.1097/ALN.0000000000002294. [PMID] 30020181.
2018
Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain.
Pain. 159(10):2115-2127 [DOI] 10.1097/j.pain.0000000000001294. [PMID] 29847471.
2018
Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(17):4212-4229 [DOI] 10.1523/JNEUROSCI.2767-17.2018. [PMID] 29636392.
2018
Unconventional Signaling by Extracellular CRMP2: Possible Role as an Atypical Neurotransmitter?
Neuroscience. 376:224-226 [DOI] 10.1016/j.neuroscience.2018.02.025. [PMID] 29555038.
2017
A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.
Channels (Austin, Tex.). 11(4):316-328 [DOI] 10.1080/19336950.2017.1299838. [PMID] 28277940.
2017
CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide.
Pain. 158(12):2301-2319 [DOI] 10.1097/j.pain.0000000000001002. [PMID] 28809766.
2017
Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.
Pain. 158(11):2203-2221 [DOI] 10.1097/j.pain.0000000000001026. [PMID] 28767512.
2017
Immunohistochemical Markers for Prospective Studies in Neurofibromatosis-1 Porcine Models.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 65(10):607-618 [DOI] 10.1369/0022155417729357. [PMID] 28846462.
2017
Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.
Pain. 158(2):347-360 [DOI] 10.1097/j.pain.0000000000000767. [PMID] 28092651.
2017
Sensitization of Ion Channels Contributes to Central and Peripheral Dysfunction in Neurofibromatosis Type 1.
Molecular neurobiology. 54(5):3342-3349 [DOI] 10.1007/s12035-016-9907-1. [PMID] 27167129.
2017
Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(23):5648-5658 [DOI] 10.1523/JNEUROSCI.3811-16.2017. [PMID] 28483976.
2017
Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents.
Anesthesiology. 127(5):813-823 [DOI] 10.1097/ALN.0000000000001812. [PMID] 28806222.
2016
(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.
Molecular neurobiology. 53(3):1959-1976 [DOI] 10.1007/s12035-015-9141-2. [PMID] 25846820.
2016
(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.
Pain. 157(7):1448-1463 [DOI] 10.1097/j.pain.0000000000000555. [PMID] 26967696.
2016
Efficacy of (S)-Lacosamide in preclinical models of cephalic pain.
Pain reports. 1(1) [PMID] 27917413.
2016
Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.
Proceedings of the National Academy of Sciences of the United States of America. 113(52):E8443-E8452 [DOI] 10.1073/pnas.1610531113. [PMID] 27940916.
2016
Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.
Pain. 157(9):2124-2140 [DOI] 10.1097/j.pain.0000000000000628. [PMID] 27537210.
2015
A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors.
Pain. 156(7):1247-1264 [DOI] 10.1097/j.pain.0000000000000147. [PMID] 25782368.
2015
CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.
Cancer research. 75(17):3519-28 [DOI] 10.1158/0008-5472.CAN-14-0631. [PMID] 26122847.
2014
Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides.
Frontiers in cellular neuroscience. 8 [DOI] 10.3389/fncel.2014.00471. [PMID] 25674050.
2014
Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain.
Brain, behavior, and immunity. 42:169-77 [DOI] 10.1016/j.bbi.2014.06.199. [PMID] 25014009.
2014
Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase.
Nature neuroscience. 17(11):1583-90 [DOI] 10.1038/nn.3822. [PMID] 25242307.
2014
The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth.
Frontiers in cellular neuroscience. 8 [DOI] 10.3389/fncel.2014.00196. [PMID] 25104922.
2013
Challenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides.
Neuroscience letters. 557 Pt A(0 0):27-36 [DOI] 10.1016/j.neulet.2013.06.057. [PMID] 23831344.
2013
Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide.
Journal of neurochemistry. 124(6):869-79 [DOI] 10.1111/jnc.12070. [PMID] 23106100.
2012
Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.
FEBS letters. 586(21):3813-8 [DOI] 10.1016/j.febslet.2012.09.022. [PMID] 23022559.
2012
CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy.
Molecular pain. 8 [DOI] 10.1186/1744-8069-8-54. [PMID] 22828369.
2012
Inhibition of transmitter release and attenuation of anti-retroviral-associated and tibial nerve injury-related painful peripheral neuropathy by novel synthetic Ca2+ channel peptides.
The Journal of biological chemistry. 287(42):35065-35077 [DOI] 10.1074/jbc.M112.378695. [PMID] 22891239.
2012
Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling.
Journal of neuroinflammation. 9 [DOI] 10.1186/1742-2094-9-200. [PMID] 22898544.
2012
Opening Pandora’s jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders.
Future neurology. 7(6):749-771 [PMID] 23308041.
2011
Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex.
Nature medicine. 17(7):822-9 [DOI] 10.1038/nm.2345. [PMID] 21642979.
2007
Munc18: a presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein.
Channels (Austin, Tex.). 1(1):11-20 [PMID] 19170253.

Grants

Jan 2024 ACTIVE
Endosomal mechanisms signaling oral cancer pain
Role: Principal Investigator
Funding: NEW YORK UNIV via NATL INST OF HLTH NIDCR
Jan 2024 ACTIVE
Lymphocyte Antigen 6 (Ly6) Proteins: New Players in Chronic Pain
Role: Other
Funding: NATL INST OF HLTH NINDS
Jan 2024 ACTIVE
Validation of Spinal Neurotensin Receptor 2 as an Analgesic Target
Role: Principal Investigator
Funding: UNIV OF TEXAS SW MEDICAL CENTER via NATL INST OF HLTH NINDS

Contact Details

Phones:
Business:
(520) 271-0433
Emails:
Business:
r.khanna@ufl.edu
Addresses:
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