Rajesh Khanna,
Richard And Thelma O.C. Barney Term Professor And Director, Pain And Addiction Therapeutics (PATH) Collaboratory
Department:
MD-PHARMACOLOGY / THERAPEUTICS
Business Phone:
(520) 271-0433
Business Email:
r.khanna@ufl.edu
About Rajesh Khanna
Additional Positions:
Director, Pain and Addiction Therapeutics (PATH) Collaboratory
2024 – Current
·
University of Florida
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-9066-2969
Publications
2024
A parabrachial hub for the prioritization of survival behavior.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.02.26.582069.
[PMID] 38464066.
2024
C-H Functionalization-Enabled 11-Step Semisynthesis of (-)-Veragranine A and Characterization of Synthetic Analogs in Osteoarthritis-related Pain Treatment.
Journal of the American Chemical Society.
146(24):16698-705
[DOI] 10.1021/jacs.4c04025.
[PMID] 38843262.
2024
Effect of Crude Extract from the Sea Anemone Bunodeopsis globulifera on Voltage-Gated Ion Channels from Central and Peripheral Murine Nervous Systems.
Pharmaceuticals (Basel, Switzerland).
17(8)
[DOI] 10.3390/ph17081006.
[PMID] 39204111.
2024
Green light exposure in children with autism spectrum disorder: a pilot study.
The Journal of clinical pediatric dentistry.
48(4):99-107
[DOI] 10.22514/jocpd.2024.083.
[PMID] 39087219.
2024
Mechanism, and treatment of anti-CV2/CRMP5 autoimmune pain.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.05.04.592533.
[PMID] 38766071.
2024
Mouse models of non-dystrophic and dystrophic myotonia exhibit nociplastic pain-like behaviors.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.06.19.599732.
[PMID] 38948724.
2024
Neuropilin-1 is a co-receptor for NGF and TrkA-evoked pain.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.12.06.570398.
[PMID] 38106002.
2024
NF1+/ex42del miniswine model the cellular disruptions and behavioral presentations of NF1-associated cognitive and motor impairment.
Clinical and translational science.
17(6)
[DOI] 10.1111/cts.13858.
[PMID] 38932491.
2024
Nociplastic pain mechanisms and toll-like receptors as promising targets for its management.
Pain.
165(10):2150-2164
[DOI] 10.1097/j.pain.0000000000003238.
[PMID] 38595206.
2024
Peptide and Peptidomimetic Inhibitors Targeting the Interaction of Collapsin Response Mediator Protein 2 with the N-Type Calcium Channel for Pain Relief.
ACS pharmacology & translational science.
7(7):1916-1936
[DOI] 10.1021/acsptsci.4c00181.
[PMID] 39022365.
2024
Regulating neuronal excitability: The role of S-palmitoylation in NaV1.7 activity and voltage sensitivity.
PNAS nexus.
3(6)
[DOI] 10.1093/pnasnexus/pgae222.
[PMID] 38894876.
2024
Small molecule targeting NaV1.7 via inhibition of CRMP2-Ubc9 interaction reduces pain-related outcomes in a rodent osteoarthritic model.
Pain.
[DOI] 10.1097/j.pain.0000000000003357.
[PMID] 39106443.
2024
STINGing away the pain: the role of interferon-stimulated genes.
The Journal of clinical investigation.
134(9)
[DOI] 10.1172/JCI180497.
[PMID] 38690736.
2024
Uncoupling the CRMP2-CaV2.2 Interaction Reduces Pain-Like Behavior in a Preclinical Joint-Pain Model.
The journal of pain.
[DOI] 10.1016/j.jpain.2024.104664.
[PMID] 39233208.
2024
Uncoupling the CRMP2-CaV2.2 interaction reduces pain-like behavior in a preclinical osteoarthritis model.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.06.05.596514.
[PMID] 38895294.
2023
A new polymodal gating model of the proton-activated chloride channel.
PLoS biology.
21(9)
[DOI] 10.1371/journal.pbio.3002309.
[PMID] 37713449.
2023
A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain.
Proceedings of the National Academy of Sciences of the United States of America.
120(47)
[DOI] 10.1073/pnas.2305215120.
[PMID] 37972067.
2023
Argentatin C Analogues with Potential Antinociceptive Activity and Other Triterpenoid Constituents from the Aerial Parts of Parthenium incanum.
ACS omega.
8(22):20085-20095
[DOI] 10.1021/acsomega.3c02302.
[PMID] 37305315.
2023
Betulinic acid analogs inhibit N- and T-type voltage-gated calcium channels to attenuate nerve-injury associated neuropathic and formalin models of pain.
Neurobiology of pain (Cambridge, Mass.).
13
[DOI] 10.1016/j.ynpai.2023.100116.
[PMID] 36687466.
2023
Chronic pain recruits hypothalamic dynorphin/kappa opioid receptor signalling to promote wakefulness and vigilance.
Brain : a journal of neurology.
146(3):1186-1199
[DOI] 10.1093/brain/awac153.
[PMID] 35485490.
2023
Glutamatergic and GABAergic neurons in the vLGN mediate the nociceptive effects of green and red light on neuropathic pain.
Neurobiology of disease.
183
[DOI] 10.1016/j.nbd.2023.106164.
[PMID] 37217103.
2023
Identification and targeting of a unique NaV1.7 domain driving chronic pain.
Proceedings of the National Academy of Sciences of the United States of America.
120(32)
[DOI] 10.1073/pnas.2217800120.
[PMID] 37498871.
2023
Intranasal CRMP2-Ubc9 Inhibitor Regulates Na V 1.7 to Alleviate Trigeminal Neuropathic Pain.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.07.16.549195.
[PMID] 37502910.
2023
Neuropilin-1 is essential for vascular endothelial growth factor A-mediated increase of sensory neuron activity and development of pain-like behaviors.
Pain.
164(12):2696-2710
[DOI] 10.1097/j.pain.0000000000002970.
[PMID] 37366599.
2023
Some Like It Hot: Dynamic Control of Cav2.2 Channels By Chili Peppers.
Function (Oxford, England).
4(1)
[DOI] 10.1093/function/zqac066.
[PMID] 36632472.
2023
Targeting the vascular endothelial growth factor A/neuropilin 1 axis for relief of neuropathic pain.
Pain.
164(7):1473-1488
[DOI] 10.1097/j.pain.0000000000002850.
[PMID] 36729125.
2023
The Ca2+ channel ORAI1 is a regulator of oral cancer growth and nociceptive pain.
Science signaling.
16(801)
[DOI] 10.1126/scisignal.adf9535.
[PMID] 37669398.
2023
The Emerging Translational Potential of MNK Inhibitors for the Treatment of Chronic Pain.
Neuroscience.
515:93-95
[DOI] 10.1016/j.neuroscience.2023.02.009.
[PMID] 36922084.
2023
The natural product argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels.
British journal of pharmacology.
180(9):1267-1285
[DOI] 10.1111/bph.15974.
[PMID] 36245395.
2022
A prolactin-dependent sexually dimorphic mechanism of migraine chronification.
Cephalalgia : an international journal of headache.
42(3):197-208
[DOI] 10.1177/03331024211039813.
[PMID] 34510920.
2022
Alternaria alternata-induced airway epithelial signaling and inflammatory responses via protease-activated receptor-2 expression.
Biochemical and biophysical research communications.
591:13-19
[DOI] 10.1016/j.bbrc.2021.12.090.
[PMID] 34990903.
2022
Ca V 3.2 calcium channels: new players in facial pain.
Pain.
163(12):e1166-e1168
[DOI] 10.1097/j.pain.0000000000002652.
[PMID] 35442930.
2022
Cell specific regulation of NaV1.7 activity and trafficking in rat nodose ganglia neurons.
Neurobiology of pain (Cambridge, Mass.).
12
[DOI] 10.1016/j.ynpai.2022.100109.
[PMID] 36531612.
2022
Conditional knockout of CRMP2 in neurons, but not astrocytes, disrupts spinal nociceptive neurotransmission to control the initiation and maintenance of chronic neuropathic pain.
Pain.
163(2):e368-e381
[DOI] 10.1097/j.pain.0000000000002344.
[PMID] 35029600.
2022
Conotoxin contulakin-G engages a neurotensin receptor 2/R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception.
Pain.
163(9):1751-1762
[DOI] 10.1097/j.pain.0000000000002561.
[PMID] 35050960.
2022
Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine.
Brain : a journal of neurology.
145(8):2894-2909
[DOI] 10.1093/brain/awac104.
[PMID] 35325034.
2022
Effect of morphine and ibuprofen on nociceptive behavior, preening and motor activity following tonic chemical pain in the Japanese quail (Coturnix japonica).
Veterinary anaesthesia and analgesia.
49(5):499-509
[DOI] 10.1016/j.vaa.2022.07.001.
[PMID] 35961922.
2022
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.
Scientific reports.
12(1)
[DOI] 10.1038/s41598-022-12191-8.
[PMID] 35581326.
2022
Neurodegenerative Diseases: From Dysproteostasis, Altered Calcium Signalosome to Selective Neuronal Vulnerability to AAV-Mediated Gene Therapy.
International journal of molecular sciences.
23(22)
[DOI] 10.3390/ijms232214188.
[PMID] 36430666.
2022
Neuronal allodynic mechanisms of Slc7a5 (LAT1) in the spared nerve injury rodent model of neuropathic pain.
Pflugers Archiv : European journal of physiology.
474(4):397-403
[DOI] 10.1007/s00424-021-02653-9.
[PMID] 35048187.
2022
Neuronal CRMP2 phosphorylation inhibition by the flavonoid, naringenin, contributes to the reversal of spinal sensitization and arthritic pain improvement.
Arthritis research & therapy.
24(1)
[DOI] 10.1186/s13075-022-02975-8.
[PMID] 36564853.
2022
Plant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels.
Channels (Austin, Tex.).
16(1):198-215
[DOI] 10.1080/19336950.2022.2103234.
[PMID] 36017978.
2022
Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces and prevents pain chronification in a mouse model of oxaliplatin-induced neuropathic pain.
Neurobiology of pain (Cambridge, Mass.).
11
[DOI] 10.1016/j.ynpai.2021.100082.
[PMID] 35024498.
2022
Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats.
Channels (Austin, Tex.).
16(1):1-8
[DOI] 10.1080/19336950.2021.2023383.
[PMID] 34983286.
2022
Stereospecific Effects of Benzimidazolonepiperidine Compounds on T-Type Ca2+ Channels and Pain.
ACS chemical neuroscience.
13(13):2035-2047
[DOI] 10.1021/acschemneuro.2c00256.
[PMID] 35671441.
2022
The small molecule compound C65780 alleviates pain by stabilizing voltage-gated sodium channels in the inactivated and slowly-recovering state.
Neuropharmacology.
212
[DOI] 10.1016/j.neuropharm.2022.109057.
[PMID] 35413303.
2022
Transmembrane protein TMEM184B is necessary for interleukin-31-induced itch.
Pain.
163(5):e642-e653
[DOI] 10.1097/j.pain.0000000000002452.
[PMID] 34629389.
2021
Comparison of quinazoline and benzoylpyrazoline chemotypes targeting the CaVα-β interaction as antagonists of the N-type CaV2.2 channel.
Channels (Austin, Tex.).
15(1):128-135
[DOI] 10.1080/19336950.2020.1863595.
[PMID] 33416017.
2021
Evaluation of green light exposure on headache frequency and quality of life in migraine patients: A preliminary one-way cross-over clinical trial.
Cephalalgia : an international journal of headache.
41(2):135-147
[DOI] 10.1177/0333102420956711.
[PMID] 32903062.
2021
Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency.
Neurobiology of disease.
149
[DOI] 10.1016/j.nbd.2020.105224.
[PMID] 33359140.
2021
Green Light Antinociceptive and Reversal of Thermal and Mechanical Hypersensitivity Effects Rely on Endogenous Opioid System Stimulation.
The journal of pain.
22(12):1646-1656
[DOI] 10.1016/j.jpain.2021.05.006.
[PMID] 34157406.
2021
Green Light Exposure Improves Pain and Quality of Life in Fibromyalgia Patients: A Preliminary One-Way Crossover Clinical Trial.
Pain medicine (Malden, Mass.).
22(1):118-130
[DOI] 10.1093/pm/pnaa329.
[PMID] 33155057.
2021
Inhibition of autophagy by CRMP2-derived peptide ST2-104 (R9-CBD3) via a CaMKKβ/AMPK/mTOR pathway contributes to ischemic postconditioning-induced neuroprotection against cerebral ischemia-reperfusion injury.
Molecular brain.
14(1)
[DOI] 10.1186/s13041-021-00836-0.
[PMID] 34362425.
2021
Intellectual disability: dendritic anomalies and emerging genetic perspectives.
Acta neuropathologica.
141(2):139-158
[DOI] 10.1007/s00401-020-02244-5.
[PMID] 33226471.
2021
L5-6 Spinal Nerve Ligation-induced Neuropathy Changes the Location and Function of Ca2+ Channels and Cdk5 and Affects the Compound Action Potential in Adjacent Intact L4 Afferent Fibers.
Neuroscience.
471:20-31
[DOI] 10.1016/j.neuroscience.2021.07.013.
[PMID] 34303780.
2021
Missense variants in DPYSL5 cause a neurodevelopmental disorder with corpus callosum agenesis and cerebellar abnormalities.
American journal of human genetics.
108(5):951-961
[DOI] 10.1016/j.ajhg.2021.04.004.
[PMID] 33894126.
2021
Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15.
Molecular brain.
14(1)
[DOI] 10.1186/s13041-020-00714-1.
[PMID] 33478555.
2021
Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry.
ACS chemical neuroscience.
12(8):1299-1312
[DOI] 10.1021/acschemneuro.0c00619.
[PMID] 33787218.
2021
SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia.
Pain.
162(1):243-252
[DOI] 10.1097/j.pain.0000000000002097.
[PMID] 33009246.
2021
Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents.
Science translational medicine.
13(619)
[DOI] 10.1126/scitranslmed.abh1314.
[PMID] 34757807.
2021
Targeting T-type/CaV3.2 channels for chronic pain.
Translational research : the journal of laboratory and clinical medicine.
234:20-30
[DOI] 10.1016/j.trsl.2021.01.002.
[PMID] 33422652.
2021
The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area.
Frontiers in pharmacology.
12
[DOI] 10.3389/fphar.2021.632757.
[PMID] 33953672.
2020
1-O-Acetylgeopyxin A, a derivative of a fungal metabolite, blocks tetrodotoxin-sensitive voltage-gated sodium, calcium channels and neuronal excitability which correlates with inhibition of neuropathic pain.
Molecular brain.
13(1)
[DOI] 10.1186/s13041-020-00616-2.
[PMID] 32393368.
2020
A modulator of the low-voltage-activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies.
Pain.
161(11):2551-2570
[DOI] 10.1097/j.pain.0000000000001955.
[PMID] 32541387.
2020
Collapsin Response Mediator Proteins: Novel Targets for Alzheimer’s Disease.
Journal of Alzheimer's disease : JAD.
77(3):949-960
[DOI] 10.3233/JAD-200721.
[PMID] 32804096.
2020
Coordinating Synaptic Signaling with CRMP2.
The international journal of biochemistry & cell biology.
124
[DOI] 10.1016/j.biocel.2020.105759.
[PMID] 32437854.
2020
Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury.
Molecular brain.
13(1)
[DOI] 10.1186/s13041-020-00633-1.
[PMID] 32571373.
2020
Druggability of CRMP2 for Neurodegenerative Diseases.
ACS chemical neuroscience.
11(17):2492-2505
[DOI] 10.1021/acschemneuro.0c00307.
[PMID] 32693579.
2020
Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking.
Molecular neurobiology.
57(1):346-357
[DOI] 10.1007/s12035-019-01711-9.
[PMID] 31359322.
2020
In silico identification and validation of inhibitors of the interaction between neuropilin receptor 1 and SARS-CoV-2 Spike protein.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2020.09.22.308783.
[PMID] 32995772.
2020
Just in time! Identification of a novel mechanism for treating PIPN.
The Journal of physiology.
598(12):2283-2284
[DOI] 10.1113/JP279863.
[PMID] 32266977.
2020
Longitudinal phenotype development in a minipig model of neurofibromatosis type 1.
Scientific reports.
10(1)
[DOI] 10.1038/s41598-020-61251-4.
[PMID] 32193437.
2020
Nasal delivery of a CRMP2-derived CBD3 adenovirus improves cognitive function and pathology in APP/PS1 transgenic mice.
Molecular brain.
13(1)
[DOI] 10.1186/s13041-020-00596-3.
[PMID] 32272942.
2020
Putative roles of SLC7A5 (LAT1) transporter in pain.
Neurobiology of pain (Cambridge, Mass.).
8
[DOI] 10.1016/j.ynpai.2020.100050.
[PMID] 32715162.
2020
SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2020.07.17.209288.
[PMID] 32869019.
2020
Sculpting Dendritic Spines during Initiation and Maintenance of Neuropathic Pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
40(40):7578-7589
[DOI] 10.1523/JNEUROSCI.1664-20.2020.
[PMID] 32998955.
2020
Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific Nav1.7 regulation in the pathogenesis of chronic neuropathic pain.
Pain.
161(11):2629-2651
[DOI] 10.1097/j.pain.0000000000001951.
[PMID] 32569093.
2020
Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1.
Science advances.
6(27)
[DOI] 10.1126/sciadv.abb1515.
[PMID] 32937457.
2020
Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels.
Science advances.
6(27)
[DOI] 10.1126/sciadv.aaz8110.
[PMID] 32937450.
2020
The investigation of the T-type calcium channel enhancer SAK3 in an animal model of TAF1 intellectual disability syndrome.
Neurobiology of disease.
143
[DOI] 10.1016/j.nbd.2020.105006.
[PMID] 32622085.
2020
The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females.
Science translational medicine.
12(529)
[DOI] 10.1126/scitranslmed.aay7550.
[PMID] 32024801.
2020
The role of cyclin-dependent kinase 5 in neuropathic pain.
Pain.
161(12):2674-2689
[DOI] 10.1097/j.pain.0000000000002027.
[PMID] 32773603.
2020
Validating indicators of CNS disorders in a swine model of neurological disease.
PloS one.
15(2)
[DOI] 10.1371/journal.pone.0228222.
[PMID] 32074109.
2019
(-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels.
ACS chemical neuroscience.
10(3):1716-1728
[DOI] 10.1021/acschemneuro.8b00617.
[PMID] 30525440.
2019
AAV-encoded CaV2.2 peptide aptamer CBD3A6K for primary sensory neuron-targeted treatment of established neuropathic pain.
Gene therapy.
26(7-8):308-323
[DOI] 10.1038/s41434-019-0082-7.
[PMID] 31118475.
2019
Activity of T-type calcium channels is independent of CRMP2 in sensory neurons.
Channels (Austin, Tex.).
13(1):147-152
[DOI] 10.1080/19336950.2019.1608129.
[PMID] 31025580.
2019
Assessment of nociception and related quality-of-life measures in a porcine model of neurofibromatosis type 1.
Pain.
160(11):2473-2486
[DOI] 10.1097/j.pain.0000000000001648.
[PMID] 31246731.
2019
Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels.
Pain.
160(1):117-135
[DOI] 10.1097/j.pain.0000000000001385.
[PMID] 30169422.
2019
Cdk5-mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain.
Neurobiology of pain (Cambridge, Mass.).
5
[DOI] 10.1016/j.ynpai.2018.07.003.
[PMID] 31080913.
2019
Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant.
Proceedings of the National Academy of Sciences of the United States of America.
116(31):15696-15705
[DOI] 10.1073/pnas.1903401116.
[PMID] 31308225.
2019
Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light.
The journal of pain.
20(11):1293-1306
[DOI] 10.1016/j.jpain.2019.04.008.
[PMID] 31054915.
2019
Discovery of Quinoline Analogues as Potent Antivirals against Enterovirus D68 (EV-D68).
Journal of medicinal chemistry.
62(8):4074-4090
[DOI] 10.1021/acs.jmedchem.9b00115.
[PMID] 30912944.
2019
Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions.
Molecular neurobiology.
56(10):6736-6755
[DOI] 10.1007/s12035-019-1568-4.
[PMID] 30915713.
2019
Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light’: The Journal of Pain 20 (2019) 1293-1306.
The journal of pain.
20(12)
[DOI] 10.1016/j.jpain.2019.11.012.
[PMID] 31818395.
2019
Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief.
Channels (Austin, Tex.).
13(1):498-504
[DOI] 10.1080/19336950.2019.1684608.
[PMID] 31680630.
2019
Mining the Nav1.7 interactome: Opportunities for chronic pain therapeutics.
Biochemical pharmacology.
163:9-20
[DOI] 10.1016/j.bcp.2019.01.018.
[PMID] 30699328.
2019
Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease.
Neuronal signaling.
3(2)
[DOI] 10.1042/NS20190001.
[PMID] 32269836.
2019
Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis.
ASN neuro.
11
[DOI] 10.1177/1759091419892090.
[PMID] 31795726.
2019
Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission.
Molecular neurobiology.
56(7):5241-5255
[DOI] 10.1007/s12035-018-1445-6.
[PMID] 30565051.
2019
Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Physalin F via Block of CaV2.3 (R-Type) and CaV2.2 (N-Type) Voltage-Gated Calcium Channels.
ACS chemical neuroscience.
10(6):2939-2955
[DOI] 10.1021/acschemneuro.9b00166.
[PMID] 30946560.
2019
Small Molecule Targeting TDP-43’s RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS).
ACS chemical biology.
14(9):2006-2013
[DOI] 10.1021/acschembio.9b00481.
[PMID] 31241884.
2019
TAF1-gene editing alters the morphology and function of the cerebellum and cerebral cortex.
Neurobiology of disease.
132
[DOI] 10.1016/j.nbd.2019.104539.
[PMID] 31344492.
2019
Targeting the CaVα-CaVβ interaction yields an antagonist of the N-type CaV2.2 channel with broad antinociceptive efficacy.
Pain.
160(7):1644-1661
[DOI] 10.1097/j.pain.0000000000001524.
[PMID] 30933958.
2019
Tetramethylpyrazine Reduces Epileptogenesis Progression in Electrical Kindling Models by Modulating Hippocampal Excitatory Neurotransmission.
ACS chemical neuroscience.
10(12):4854-4863
[DOI] 10.1021/acschemneuro.9b00575.
[PMID] 31756074.
2019
The Natural Flavonoid Naringenin Elicits Analgesia through Inhibition of NaV1.8 Voltage-Gated Sodium Channels.
ACS chemical neuroscience.
10(12):4834-4846
[DOI] 10.1021/acschemneuro.9b00547.
[PMID] 31697467.
2019
TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation.
Molecular brain.
12(1)
[DOI] 10.1186/s13041-019-0538-0.
[PMID] 31888677.
2019
Towards a neurobiological understanding of pain in neurofibromatosis type 1: mechanisms and implications for treatment.
Pain.
160(5):1007-1018
[DOI] 10.1097/j.pain.0000000000001486.
[PMID] 31009417.
2018
A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).
ACS chemical biology.
13(10):3000-3010
[DOI] 10.1021/acschembio.8b00745.
[PMID] 30141626.
2018
A light-gated potassium channel for sustained neuronal inhibition.
Nature methods.
15(11):969-976
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[PMID] 30377377.
2018
A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome.
Neuronal signaling.
2(3)
[DOI] 10.1042/NS20180141.
[PMID] 32714589.
2018
A porcine model of neurofibromatosis type 1 that mimics the human disease.
JCI insight.
3(12)
[DOI] 10.1172/jci.insight.120402.
[PMID] 29925695.
2018
Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels.
Channels (Austin, Tex.).
12(1):219-227
[DOI] 10.1080/19336950.2018.1491244.
[PMID] 30081699.
2018
CRMP2 and voltage-gated ion channels: potential roles in neuropathic pain.
Neuronal signaling.
2(1)
[DOI] 10.1042/NS20170220.
[PMID] 30364788.
2018
CRMP2 is necessary for Neurofibromatosis type 1 related pain.
Channels (Austin, Tex.).
12(1):47-50
[DOI] 10.1080/19336950.2017.1370524.
[PMID] 28837387.
2018
CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.
Molecular neurobiology.
55(5):4403-4416
[DOI] 10.1007/s12035-017-0653-9.
[PMID] 28660485.
2018
CRMP2-Neurofibromin Interface Drives NF1-related Pain.
Neuroscience.
381:79-90
[DOI] 10.1016/j.neuroscience.2018.04.002.
[PMID] 29655575.
2018
High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons.
eNeuro.
5(5)
[DOI] 10.1523/ENEURO.0135-18.2018.
[PMID] 30263951.
2018
Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.
British journal of pharmacology.
175(12):2244-2260
[DOI] 10.1111/bph.13737.
[PMID] 28161890.
2018
In Reply.
Anesthesiology.
129(2):378-379
[DOI] 10.1097/ALN.0000000000002294.
[PMID] 30020181.
2018
Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain.
Pain.
159(10):2115-2127
[DOI] 10.1097/j.pain.0000000000001294.
[PMID] 29847471.
2018
Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
38(17):4212-4229
[DOI] 10.1523/JNEUROSCI.2767-17.2018.
[PMID] 29636392.
2018
Unconventional Signaling by Extracellular CRMP2: Possible Role as an Atypical Neurotransmitter?
Neuroscience.
376:224-226
[DOI] 10.1016/j.neuroscience.2018.02.025.
[PMID] 29555038.
2017
A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.
Channels (Austin, Tex.).
11(4):316-328
[DOI] 10.1080/19336950.2017.1299838.
[PMID] 28277940.
2017
CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide.
Pain.
158(12):2301-2319
[DOI] 10.1097/j.pain.0000000000001002.
[PMID] 28809766.
2017
Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.
Pain.
158(11):2203-2221
[DOI] 10.1097/j.pain.0000000000001026.
[PMID] 28767512.
2017
Immunohistochemical Markers for Prospective Studies in Neurofibromatosis-1 Porcine Models.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
65(10):607-618
[DOI] 10.1369/0022155417729357.
[PMID] 28846462.
2017
Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.
Pain.
158(2):347-360
[DOI] 10.1097/j.pain.0000000000000767.
[PMID] 28092651.
2017
Sensitization of Ion Channels Contributes to Central and Peripheral Dysfunction in Neurofibromatosis Type 1.
Molecular neurobiology.
54(5):3342-3349
[DOI] 10.1007/s12035-016-9907-1.
[PMID] 27167129.
2017
Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
37(23):5648-5658
[DOI] 10.1523/JNEUROSCI.3811-16.2017.
[PMID] 28483976.
2017
Transient Receptor Potential Vanilloid 1 Antagonists Prevent Anesthesia-induced Hypothermia and Decrease Postincisional Opioid Dose Requirements in Rodents.
Anesthesiology.
127(5):813-823
[DOI] 10.1097/ALN.0000000000001812.
[PMID] 28806222.
2016
(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.
Molecular neurobiology.
53(3):1959-1976
[DOI] 10.1007/s12035-015-9141-2.
[PMID] 25846820.
2016
(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.
Pain.
157(7):1448-1463
[DOI] 10.1097/j.pain.0000000000000555.
[PMID] 26967696.
2016
Efficacy of (S)-Lacosamide in preclinical models of cephalic pain.
Pain reports.
1(1)
[PMID] 27917413.
2016
Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.
Proceedings of the National Academy of Sciences of the United States of America.
113(52):E8443-E8452
[DOI] 10.1073/pnas.1610531113.
[PMID] 27940916.
2016
Neuronal networks in mental diseases and neuropathic pain: Beyond brain derived neurotrophic factor and collapsin response mediator proteins.
World journal of psychiatry.
6(1):18-30
[DOI] 10.5498/wjp.v6.i1.18.
[PMID] 27014595.
2016
Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.
Pain.
157(9):2124-2140
[DOI] 10.1097/j.pain.0000000000000628.
[PMID] 27537210.
2015
A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors.
Pain.
156(7):1247-1264
[DOI] 10.1097/j.pain.0000000000000147.
[PMID] 25782368.
2015
Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lacosamide and safinamide.
ACS chemical neuroscience.
6(2):316-30
[DOI] 10.1021/cn5002182.
[PMID] 25418676.
2015
Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.
Bioorganic & medicinal chemistry.
23(13):3655-66
[DOI] 10.1016/j.bmc.2015.04.014.
[PMID] 25922183.
2015
CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.
Cancer research.
75(17):3519-28
[DOI] 10.1158/0008-5472.CAN-14-0631.
[PMID] 26122847.
2015
Specific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamide.
Molecular neurobiology.
51(2):599-609
[DOI] 10.1007/s12035-014-8775-9.
[PMID] 24944082.
2014
Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity.
The Journal of biological chemistry.
289(11):7470-82
[DOI] 10.1074/jbc.M113.518472.
[PMID] 24474686.
2014
Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides.
Frontiers in cellular neuroscience.
8
[DOI] 10.3389/fncel.2014.00471.
[PMID] 25674050.
2014
Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ß and CDK5 following traumatic brain injury.
Frontiers in cellular neuroscience.
8
[DOI] 10.3389/fncel.2014.00135.
[PMID] 24904280.
2014
Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain.
Brain, behavior, and immunity.
42:169-77
[DOI] 10.1016/j.bbi.2014.06.199.
[PMID] 25014009.
2014
Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase.
Nature neuroscience.
17(11):1583-90
[DOI] 10.1038/nn.3822.
[PMID] 25242307.
2014
Substituted N-(biphenyl-4′-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels.
Journal of medicinal chemistry.
57(14):6165-82
[DOI] 10.1021/jm500707r.
[PMID] 25004277.
2014
The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth.
Frontiers in cellular neuroscience.
8
[DOI] 10.3389/fncel.2014.00196.
[PMID] 25104922.
2013
(Biphenyl-4-yl)methylammonium chlorides: potent anticonvulsants that modulate Na+ currents.
Journal of medicinal chemistry.
56(14):5931-9
[DOI] 10.1021/jm4007092.
[PMID] 23772678.
2013
Benzyloxybenzylammonium chlorides: Simple amine salts that display anticonvulsant activity.
Bioorganic & medicinal chemistry.
21(24):7655-62
[DOI] 10.1016/j.bmc.2013.10.031.
[PMID] 24238903.
2013
Challenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides.
Neuroscience letters.
557 Pt A(0 0):27-36
[DOI] 10.1016/j.neulet.2013.06.057.
[PMID] 23831344.
2013
CHARACTERIZING CALCIUM INFLUX VIA VOLTAGE- AND LIGAND-GATED CALCIUM CHANNELS IN EMBRYONIC ALLIGATOR NEURONS IN CULTURE.
Translational neuroscience.
4(3)
[DOI] 10.2478/s13380-013-0132-3.
[PMID] 24260711.
2013
CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking.
The Journal of biological chemistry.
288(34):24316-31
[DOI] 10.1074/jbc.M113.474924.
[PMID] 23836888.
2013
Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis.
Bioorganic & medicinal chemistry.
21(7):2145-55
[DOI] 10.1016/j.bmc.2012.12.047.
[PMID] 23411397.
2013
Suppression of pain-related behavior in two distinct rodent models of peripheral neuropathy by a homopolyarginine-conjugated CRMP2 peptide.
Journal of neurochemistry.
124(6):869-79
[DOI] 10.1111/jnc.12070.
[PMID] 23106100.
2012
Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2.
FEBS letters.
586(21):3813-8
[DOI] 10.1016/j.febslet.2012.09.022.
[PMID] 23022559.
2012
CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy.
Molecular pain.
8
[DOI] 10.1186/1744-8069-8-54.
[PMID] 22828369.
2012
Identification of the benzyloxyphenyl pharmacophore: a structural unit that promotes sodium channel slow inactivation.
ACS chemical neuroscience.
3(12):1037-49
[DOI] 10.1021/cn300129d.
[PMID] 23259039.
2012
Inhibition of transmitter release and attenuation of anti-retroviral-associated and tibial nerve injury-related painful peripheral neuropathy by novel synthetic Ca2+ channel peptides.
The Journal of biological chemistry.
287(42):35065-35077
[DOI] 10.1074/jbc.M112.378695.
[PMID] 22891239.
2012
Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling.
Journal of neuroinflammation.
9
[DOI] 10.1186/1742-2094-9-200.
[PMID] 22898544.
2012
Opening Pandora’s jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders.
Future neurology.
7(6):749-771
[PMID] 23308041.
2012
The persistent release of HMGB1 contributes to tactile hyperalgesia in a rodent model of neuropathic pain.
Journal of neuroinflammation.
9
[DOI] 10.1186/1742-2094-9-180.
[PMID] 22824385.
2011
Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage-gated sodium channels.
ACS chemical neuroscience.
2(2):90-106
[PMID] 21532923.
2011
Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex.
Channels (Austin, Tex.).
5(5):449-56
[DOI] 10.4161/chan.5.5.17363.
[PMID] 21829088.
2011
Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-gated Sodium Channels and in the Treatment of Neuropathic Pain.
ACS chemical neuroscience.
2(6):317-322
[PMID] 21765969.
2011
Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP2).
The Journal of biological chemistry.
286(43):37778-92
[DOI] 10.1074/jbc.M111.255455.
[PMID] 21832084.
2011
Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex.
Nature medicine.
17(7):822-9
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[PMID] 21642979.
2011
Targeting multiple conformations leads to small molecule inhibitors of the uPAR·uPA protein-protein interaction that block cancer cell invasion.
ACS chemical biology.
6(11):1232-43
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[PMID] 21875078.
2011
VOLTAGE-GATED CALCIUM CHANNELS ARE NOT AFFECTED BY THE NOVEL ANTI-EPILEPTIC DRUG LACOSAMIDE.
Translational neuroscience.
2(1):13-22
[PMID] 21949591.
2010
Emerging roles of collapsin response mediator proteins (CRMPs) as regulators of voltage-gated calcium channels and synaptic transmission.
Communicative & integrative biology.
3(2):172-5
[PMID] 20585514.
2010
In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation.
The Journal of biological chemistry.
285(33):25296-307
[DOI] 10.1074/jbc.M110.128801.
[PMID] 20538611.
2009
An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels.
The Journal of biological chemistry.
284(45):31375-90
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[PMID] 19755421.
2009
Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons.
Journal of cell science.
122(Pt 23):4351-62
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[PMID] 19903690.
2007
A proteomic screen for presynaptic terminal N-type calcium channel (CaV2.2) binding partners.
Journal of biochemistry and molecular biology.
40(3):302-14
[PMID] 17562281.
2007
Munc18: a presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein.
Channels (Austin, Tex.).
1(1):11-20
[PMID] 19170253.
Grants
Sep 2024
ACTIVE
Validation of a Nonopioid Analgesic Pathway in Human Sensory Ganglia and Spinal Cord
Role: Principal Investigator
Funding: US ARMY MED RES ACQUISITION
Sep 2024
ACTIVE
Antagonists of CRMP2 Phosphorylation for Chemotherapy-Induced Peripheral Neuropathy
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jan 2024
ACTIVE
Endosomal mechanisms signaling oral cancer pain
Role: Principal Investigator
Funding: NEW YORK UNIV
via NATL INST OF HLTH NIDCR
Jan 2024
ACTIVE
Validation of Neuropilin-1 Receptor Signaling in Nociceptive Processing
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Jan 2024
ACTIVE
Lymphocyte Antigen 6 (Ly6) Proteins: New Players in Chronic Pain
Role: Other
Funding: NATL INST OF HLTH NINDS
Jan 2024
ACTIVE
Validation of Spinal Neurotensin Receptor 2 as an Analgesic Target
Role: Principal Investigator
Funding: UNIV OF TEXAS SW MEDICAL CENTER
via NATL INST OF HLTH NINDS
Jan 2024
ACTIVE
Genetic and Pharmacological Validation of CRMP2 Phosphorylation as a Novel therapeutic Target for Neuropathic Pain
Role: Principal Investigator
Funding: NATL INST OF HLTH NINDS
Contact Details
Phones:
- Business:
- (520) 271-0433
Emails:
- Business:
- r.khanna@ufl.edu
Addresses:
- Business Mailing:
-
L4-177
1149 Newell Drive
GAINESVILLE FL 32610 - Business Street:
-
PO Box 100267
GAINESVILLE FL 32610