William R Kem

William R Kem, Ph.D.

PROFESSOR

Department: MD-PHARMACOLOGY / THERAPEUTICS
Business Phone: (352) 392-0669
Business Email: wrkem@ufl.edu

Publications

2012 Journal of Heterocyclic Chemistry
2011 American Journal of Physiology-Regulatory Integrative and Comparative Physiology
2004 Cellular and Molecular Neurobiology

Grants

Apr 2019 – Mar 2020
A translational approach to understand hippocampal neural circuitry regulating impulsive aggression
VANDERBILT UNIV MEDICAL CENTER · Principal Investigator
Oct 2015 – Dec 2016
POTENTIAL DRUG LEADS FOR NEURODEGENERATIVE DISEASES
UNIVERSITY OF ICELAND · Principal Investigator
Aug 2015 – Jul 2018
Imaging of alpha7-nAChR in healthy controls
JOHNS HOPKINS UNIV · Principal Investigator
Aug 2015 – Jul 2018
Effects of GTS-21 on smoking behavior and neurocognitive function
NATL INST OF HLTH NIDA · Project Manager
Jul 2015 ACTIVE
Nicotinic Agonist Effects on BMI and Neuronal Response in Overweight/Obese Adults
UNIVERSITY OF COLORADO DENVER · Principal Investigator
Sep 2013 – Feb 2017
Manufacture and Analyze 3-2, 4 (dimethoxy) benzylidene-anabaseine and its 2 and 4 hydroxy metabolite for human Drug Study
US DEPT OF VETERANS AFFAIRS · Principal Investigator

Patents

Issued May 1996
Use of Nicotinic Analogs for Treatment of Degenerative Diseases of the Nervous System Anabaseine, Stimulating Brain Cholinergic Transmission (CIP)
#5,516,785
Issued March 1998
Production Intermediate and Process for Producing Pyridine Derivative
#5,734,059
Issued April 1998
Anabaseine Derivatives Useful in the Treatment of Degenerative Diseases of the Nervous System (CIP)
#5,741,802
Issued November 1999
Cinnamylidene Anabaseine Compounds For Brain Disorders
#5,977,144
Issued June 2000
SHK Toxin Compositions And Methods Of Use (CIP)
#6,077,680
Issued October 2003
Use of Nicotine Analogs For Treatment of Degenerative Diseases of the Nervous System (DIV)
#6,630,491
Published June 2005
Controlling Angiogenesis with Anabaseline Analogs
#2005-0288333
Issued August 2006
Materials and Methods for Inhibiting Fouling of Surfaces Exposed to Aquatic Environments
#7,087,106
Issued December 2007
Materials and Methods for Inhibiting Fouling of Surfaces Exposed to Aquatic Environments (DIV)
#7,307,171
Issued January 2012
Alpha7 Nicotinic Receptor Selective Ligands
#8,093,269
Published February 2012
Timed-Release Formulations of GTS-21 and Related Arylidene-Anabaseines
#US-2012-0237563-A1
Issued November 2013
Alpha 7 Nicotinic Receptor Selective Ligands (CON)
#8,592,458
Issued October 2015
Nicotine Receptor Targeted Compounds and Compositions
#9,150,558
Issued January 2016
Therapies to Improve Smoking Cessation in Neuropsychiatric and Depressed Patients
#9,233,109
Issued September 2016
Therapeutic Nicotine and 1-Methyl-2-(3-Pyridyl)-Azetidine Analogs
#9,440,948

Contact Details

Phones:
Business:
(352) 392-0669
Emails:
Business:
wrkem@ufl.edu