About Stephan C Jahn
Jahn is a graduate of the department of Pharmacology and Therapeutics here at the University of Florida. During his graduate work, his studies focused on cancer biology and the development of novel therapeutics using in silico molecular docking. He then worked at UF in the colleges of Medicine and Pharmacy, studying drug metabolism, drug resistance and exploring next-generation sequencing as a means to identify new targets in the treatment of lymphoma.
He enjoys teaching and has taught at the high school, undergraduate and graduate levels. Having returned to his previous department, he’s able to combine his scientific and teaching skill-sets to further the educational mission of the department. In addition to teaching professional and graduate students, his primary role is in coordinating the department’s online graduate programs.
Teaching Profile
Courses Taught
2019-2024
GMS6530 Medical Pharmacology and Therapeutics II: Cardiovascular, Renal and Respiratory Systems
2019-2024
GMS6531 Medical Pharmacology and Therapeutics III: Endocrine, Musculoskeletal and Reproductive Systems
2019-2024
GMS6520 Medical Pharmacology and Therapeutics I: The Nervous System
2019-2024
GMS6551 Fundamentals of Medical Pharmacology and Therapeutics
2019-2021,2023-2024
GMS6560 Molecules to Man: Past, Present and Future Therapeutic Strategies for Disease
2020-2023
PAS5026 Pharmacotherapeu 2
2019-2024
GMS6540 Medical Pharmacology and Therapeutics IV: Cancer, Antimicrobial and Antiparasitic Agents
2020-2024
GMS6510 Pharmacology of Cannabis, Tobacco, and Vaping
2015-2016,2020-2024
GMS6009 Principles of Drug Action and Therapeutics
2020-2024
DEN6262 Prin of Pharmacology
2013,2015
GMS6051 Signal Transduction
2021-2024
GMS6504 Advanced Medical Pharmacology
2021-2024
GMS6552 Cell Signaling & Therapeutics
2022-2024
BMS6300 Fund Micro and Immuno
2023-2024
BMS6031 Foundations of Med
Publications
2021
Repurposing Tranexamic Acid as an Anticancer Agent.
Frontiers in pharmacology.
12
[DOI] 10.3389/fphar.2021.792600.
[PMID] 35095503.
2020
A Methyl Scan of the Pyrrolidinium Ring of Nicotine Reveals Significant Differences in Its Interactions with α7 and α4β2 Nicotinic Acetylcholine Receptors.
Molecular pharmacology.
98(2):168-180
[DOI] 10.1124/mol.119.118786.
[PMID] 32474444.
2020
Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.
Drug metabolism and disposition: the biological fate of chemicals.
48(7):563-569
[DOI] 10.1124/dmd.120.090639.
[PMID] 32357971.
2019
Mitochondrial Glutathione Transferase Zeta 1 Is Inactivated More Rapidly by Dichloroacetate than the Cytosolic Enzyme in Adult and Juvenile Rat Liver.
Chemical research in toxicology.
32(10):2042-2052
[DOI] 10.1021/acs.chemrestox.9b00207.
[PMID] 31524376.
2018
Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.
Drug metabolism and disposition: the biological fate of chemicals.
46(8):1118-1128
[DOI] 10.1124/dmd.118.081810.
[PMID] 29853471.
2018
Regulation of dichloroacetate biotransformation in rat liver and extrahepatic tissues by GSTZ1 expression and chloride concentration.
Biochemical pharmacology.
152:236-243
[DOI] 10.1016/j.bcp.2018.04.001.
[PMID] 29626439.
2017
Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1.
Pharmacology & therapeutics.
170:166-180
[DOI] 10.1016/j.pharmthera.2016.10.018.
[PMID] 27771434.
2016
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.
Biochimica et biophysica acta.
1860(6):1202-10
[DOI] 10.1016/j.bbagen.2016.01.024.
[PMID] 26850694.
2015
Chloride concentrations in human hepatic cytosol and mitochondria are a function of age.
Biochemical and biophysical research communications.
459(3):463-8
[DOI] 10.1016/j.bbrc.2015.02.128.
[PMID] 25748576.
2015
Novel agents that downregulate EGFR, HER2, and HER3 in parallel.
Oncotarget.
6(12):10445-59
[PMID] 25865227.
2014
Signaling mechanisms that suppress the cytostatic actions of rapamycin.
PloS one.
9(6)
[DOI] 10.1371/journal.pone.0099927.
[PMID] 24927123.
2013
Assembly, activation, and substrate specificity of cyclin D1/Cdk2 complexes.
Biochemistry.
52(20):3489-501
[DOI] 10.1021/bi400047u.
[PMID] 23627734.
2013
Constitutive Cdk2 activity promotes aneuploidy while altering the spindle assembly and tetraploidy checkpoints.
Journal of cell science.
126(Pt 5):1207-17
[DOI] 10.1242/jcs.117382.
[PMID] 23321641.
2013
Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms.
Oncogene.
32(10):1316-29
[DOI] 10.1038/onc.2012.138.
[PMID] 22543582.
2013
Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents.
Molecular cancer therapeutics.
12(5):610-20
[DOI] 10.1158/1535-7163.MCT-12-0930.
[PMID] 23625935.
2012
An in vivo model of epithelial to mesenchymal transition reveals a mitogenic switch.
Cancer letters.
326(2):183-90
[DOI] 10.1016/j.canlet.2012.08.013.
[PMID] 22906417.
2012
TGF-beta antiproliferative effects in tumor suppression.
Frontiers in bioscience (Scholar edition).
4(2):749-66
[PMID] 22202088.
2011
Activation of the NF-kappaB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapy.
Proceedings of the National Academy of Sciences of the United States of America.
108(9):3743-8
[DOI] 10.1073/pnas.1012753108.
[PMID] 21321191.
Contact Details
Emails:
- Business:
- scjahn@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100267
GAINESVILLE FL 32610 - Business Street:
-
UNIVERSITY OF FLORIDA
GAINESVILLE FL 326100001