David Hammers,
Assistant Professor
Teaching Profile
Research Profile
The Hammers Lab researches physiological and pathophysiological mechanisms of skeletal and cardiac muscle, particularly those associated with genetic diseases known as muscular dystrophies. The primary motivation of these efforts is to identify potential therapeutic targets that can be exploited to develop treatments for muscle and heart diseases using small molecules and/or adeno-associated virus (AAV)-based gene therapies.
In recent work, the Hammers Lab has identified a group of repurposed drugs that act as “remodeling therapeutics” when used to treat severely diseased muscles by reducing muscle fibrosis and rejuvenating muscle regeneration. These discoveries have led to the initiation of new projects investigating the cellular dynamics that occur during the progression of muscle diseases in the absence and presence of remodeling therapeutics, as well as evaluating the potential for these remodeling therapeutics to improve the long-term efficacy of other current or emerging muscular dystrophy treatment strategies.
- Cardiomyopathy
- Fibrosis
- Gene therapy
- Muscular dystrophy
- Regeneration
- Striated Muscle Physiology
- Therapeutic Development
0000-0003-2129-4047
Publications
Contact Details
- Business:
- (352) 273-9977
- Business:
- dhammers@ufl.edu
- Business Mailing:
-
PO Box 100267
GAINESVILLE FL 32610 - Business Street:
-
ARB Building R5-234
1200 Newell Drive
GAINESVILLE FL 32610