Prodip K Bose, MD, PhD

My name is Prodip Bose, M.D., Ph.D., and I am an Associate Professor with joint appointments in the Departments of Anesthesiology and Neurology at the University of Florida. My career has been shaped by multidisciplinary training spanning medicine, clinical neurology, neurotrauma, and neuroscience. I earned my medical degree from the University of Dhaka, completed postgraduate medical training and fellowships in neurology and neurotrauma at Case Western Reserve University School of Medicine and Northeastern Ohio Universities College of Medicine, and received my Ph.D. in Neuroscience from the University of Hong Kong College of Medicine.

In parallel with my academic appointments, I hold a joint appointment at the Malcom Randall VA Medical Center, where I direct the MRI and Translational Neurotrauma Rehabilitation Laboratory. I also lead the Rehabilitation Neuroscience Initiative within the Brain Rehabilitation Research Center, a national VA Rehabilitation Research & Development Center at the North Florida/South Georgia Veterans Health System. These leadership roles have enabled me to build a multidisciplinary research program integrating experimental neurotrauma, advanced neuroimaging, neuromodulation, neurorehabilitation, and mechanism-based therapeutic development.

My research focuses primarily on spinal cord injury, traumatic brain injury, and stroke, with the overarching goal of understanding mechanisms of secondary neurological injury and translating those discoveries into interventions that improve neurological recovery and long-term function. I currently lead multiple federally funded research programs supported by the U.S. Department of Veterans Affairs, Department of Defense, and National Institutes of Health, as well as other funding agencies. This work spans mechanistic discovery, advanced MRI/PET neuroimaging, experimental therapeutics, neuromodulation, and rehabilitation neuroscience and has resulted in numerous peer-reviewed publications, book chapters, scientific abstracts, and presentations at national and international scientific meetings.

Mentorship and development of emerging investigators have also been integral components of my academic and VA research career. During my tenure at UF and the VA, I have trained and mentored numerous undergraduate and graduate students, postdoctoral fellows, clinical fellows, junior faculty, and early-career investigators. My mentorship has included investigators pursuing competitive VA Career Development Awards (CDAs), NIH K-series career development awards, and other mentored research programs, with an emphasis on developing scientific independence, grant-writing skills, multidisciplinary collaboration, and successful careers in translational neuroscience and rehabilitation research.

Collectively, my clinical background, multidisciplinary neuroscience training, sustained federal research funding, scientific leadership, and longstanding commitment to mentorship provide a strong foundation for bridging fundamental mechanisms of CNS injury with innovative therapeutic and rehabilitation strategies. My overarching goal is not only to advance discoveries that improve outcomes for Veterans, Service Members, and others living with neurological injury, but also to develop the next generation of investigators who will carry this translational mission forward.

My research program focuses on neuroprotection, neural repair, and rehabilitation following neurotrauma and neurodegenerative disorders, with the overarching goal of translating mechanistic discoveries into therapies that improve functional recovery and quality of life. Using preclinical models of spinal cord injury, traumatic brain injury, stroke, Parkinson’s disease, multiple sclerosis, and ALS, my laboratory investigates molecular, physiological, neuroimaging, and behavioral mechanisms underlying motor, sensory, cognitive, pain, anxiety, balance, spasticity, and rigidity-related disabilities.

A major emphasis is the development of mechanism-based, multimodal therapeutic strategies, including iron chelation and oxygen-based therapies targeting iron toxicity, ischemia, oxidative stress, and chronic neuroinflammation, combined with rehabilitation and neuromodulation approaches such as transcranial magnetic stimulation, locomotor training, and targeted electrical stimulation. These studies integrate advanced MRI/PET neuroimaging, electrophysiology, behavioral outcome assessment, and cellular and molecular analyses to define mechanisms of therapeutic neuroplasticity and neuroregeneration. My federally funded research program is complemented by a strong commitment to mentoring and developing the next generation of investigators, including undergraduate and graduate students, clinical and postdoctoral fellows, junior faculty, and VA and NIH career development awardees.