Publication Alert: Papke Lab

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Please help us congratulate Dr. Papke’s Lab who published a paper in Molecular Pharmacology on November 22nd. The members who worked on the paper were Clare Stokes and Roger Papke. The publication, entitled “Insights into the differential desensitization of α4β2 nicotinic acetylcholine receptor isoforms obtained with positive allosteric modulation of mutant receptors” shows that drugs believed to be selective for therapeutic targets may cross-desensitize other targets and that, within a class of drugs, improved specificity can be achieved by using agents that reduce such cross-desensitization.